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Atogepant Disease Interactions

There are 2 disease interactions with atogepant.

Major

Atogepant (applies to atogepant) hepatic impairment

Major Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Atogepant should be avoided in patients with severe hepatic impairment. For patients with mild (Child-Pugh Class A), moderate (Child-Pugh Class B), or severe hepatic impairment (Child-Pugh Class C), total atogepant exposure increased by 24%, 15%, and 38%, respectively. During clinical trials, cases of elevated transaminase levels to over 3 times the upper limit of normal were temporally associated with atogepant use; these cases were asymptomatic and resolved within 8 weeks of discontinuation.

References

  1. (2021) "Product Information. Qulipta (atogepant)." AbbVie US LLC
Moderate

Atogepant (applies to atogepant) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

Atogepant for the treatment of chronic migraine should be avoided in patients with severe renal dysfunction. No dose adjustment is needed in patients with mild or moderate renal dysfunction.

References

  1. (2023) "Product Information. Qulipta (atogepant)." AbbVie US LLC, SUPPL-4

Atogepant drug interactions

There are 177 drug interactions with atogepant.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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