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Procainamide (Intravenous)

proe-KANE-a-mide

Intravenous route(Solution)

The use of procainamide hydrochloride as well as other antiarrhythmic agents should be reserved for patients with life-threatening ventricular arrhythmias. The prolonged administration of procainamide often leads to the development of a positive ANA test, with or without symptoms of a lupus erythematosus-like syndrome. Agranulocytosis, bone marrow depression, neutropenia, hypoplastic anemia, and thrombocytopenia in patients receiving procainamide hydrochloride have been reported, some of which were fatal. It is recommended that complete blood counts be performed at weekly intervals for the first three months of therapy, and periodically thereafter. Discontinue procainamide if hematologic disorders are identified .

Medically reviewed on Oct 31, 2018

Commonly used brand name(s)

In the U.S.

  • Pronestyl

Available Dosage Forms:

  • Solution

Therapeutic Class: Antiarrhythmic, Group IA

Uses For procainamide

Procainamide injection is used to treat irregular heartbeats and to slow an overactive heart. When the heart has a normal heartbeat (rhythm), it will work more efficiently. Procainamide works by slowing the nerve impulses in the heart and reducing the sensitivity of heart tissues.

Procainamide is available only with your doctor's prescription.

The oral dosage forms of procainamide are no longer available in the United States.

Before Using procainamide

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For procainamide, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to procainamide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of procainamide injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

No information is available on the relationship of age to the effects of procainamide injection in geriatric patients. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment in the dose for patients receiving procainamide injection.

Pregnancy

Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking procainamide, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using procainamide with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Amifampridine
  • Amisulpride
  • Bepridil
  • Cisapride
  • Dronedarone
  • Fingolimod
  • Grepafloxacin
  • Levomethadyl
  • Mesoridazine
  • Pimozide
  • Piperaquine
  • Saquinavir
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Vernakalant
  • Ziprasidone

Using procainamide with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acecainide
  • Ajmaline
  • Alcuronium
  • Alfuzosin
  • Amiodarone
  • Amitriptyline
  • Amoxapine
  • Anagrelide
  • Apomorphine
  • Aprindine
  • Aripiprazole
  • Aripiprazole Lauroxil
  • Arsenic Trioxide
  • Artemether
  • Asenapine
  • Astemizole
  • Atracurium
  • Azithromycin
  • Buprenorphine
  • Bupropion
  • Buserelin
  • Chloral Hydrate
  • Chloroquine
  • Chlorpromazine
  • Ciprofloxacin
  • Cisatracurium
  • Citalopram
  • Clarithromycin
  • Clomipramine
  • Clozapine
  • Crizotinib
  • Dabrafenib
  • Dasatinib
  • Degarelix
  • Delamanid
  • Desipramine
  • Deslorelin
  • Deutetrabenazine
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Doxacurium
  • Doxepin
  • Droperidol
  • Efavirenz
  • Eliglustat
  • Encorafenib
  • Enflurane
  • Erythromycin
  • Escitalopram
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Foscarnet
  • Gallamine
  • Gatifloxacin
  • Gemifloxacin
  • Gonadorelin
  • Goserelin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Halothane
  • Hexafluorenium
  • Histrelin
  • Hydroquinidine
  • Hydroxychloroquine
  • Hydroxyzine
  • Ibutilide
  • Iloperidone
  • Imipramine
  • Inotuzumab Ozogamicin
  • Isoflurane
  • Isradipine
  • Ivabradine
  • Ivosidenib
  • Ketoconazole
  • Lapatinib
  • Leuprolide
  • Levofloxacin
  • Lidocaine
  • Lidoflazine
  • Lofexidine
  • Lopinavir
  • Lorcainide
  • Lumefantrine
  • Macimorelin
  • Mefloquine
  • Methadone
  • Metocurine
  • Metronidazole
  • Mifepristone
  • Mivacurium
  • Moricizine
  • Moxifloxacin
  • Nafarelin
  • Nalidixic Acid
  • Nilotinib
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Ondansetron
  • Osimertinib
  • Paliperidone
  • Pancuronium
  • Pasireotide
  • Pazopanib
  • Pentamidine
  • Pimavanserin
  • Pipecuronium
  • Pirmenol
  • Pitolisant
  • Posaconazole
  • Prilocaine
  • Probucol
  • Procainamide
  • Promethazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Ribociclib
  • Risperidone
  • Rocuronium
  • Salmeterol
  • Sertindole
  • Sertraline
  • Sevoflurane
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Spiramycin
  • Succinylcholine
  • Sulfamethoxazole
  • Sulpiride
  • Sultopride
  • Sunitinib
  • Tacrolimus
  • Telavancin
  • Telithromycin
  • Tetrabenazine
  • Tizanidine
  • Toremifene
  • Trazodone
  • Trifluoperazine
  • Trimethoprim
  • Trimipramine
  • Triptorelin
  • Tubocurarine
  • Vandetanib
  • Vardenafil
  • Vasopressin
  • Vecuronium
  • Vemurafenib
  • Vinflunine
  • Voriconazole
  • Zolmitriptan
  • Zotepine
  • Zuclopenthixol

Using procainamide with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Cimetidine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of procainamide. Make sure you tell your doctor if you have any other medical problems, especially:

  • Heart block or
  • Heart rhythm problem (e.g., QT prolongation) or
  • Lupus erythematosus, history of—Should not use in patients with these conditions.
  • Heart failure, congestive or
  • Myasthenia gravis—May make these conditions worse.
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal from the body.

Proper Use of procainamide

A nurse or other trained health professional will give you procainamide in a hospital. Procainamide is given through a needle placed in one of your veins.

Your doctor will only give you a few doses of procainamide until your condition improves, and then you may be switched to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

Precautions While Using procainamide

It is important that your doctor check your progress carefully while you are receiving procainamide to make sure it is working properly. This will allow necessary changes in the amount of medicine you receive and may also help reduce side effects.

Dizziness or lightheadedness may occur with procainamide, especially in elderly patients and when large doses are used. Patients should use extra care to avoid falling. Make sure you know how you react to procainamide before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

Procainamide Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common

  • Fever and chills
  • joint pain or swelling
  • pains with breathing
  • skin rash or itching

Rare

  • Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, or warmth at the injection site
  • Confusion
  • fever or sore mouth, gums, or throat
  • hallucinations (seeing, hearing, or feeling things that are not there)
  • mental depression
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  • Decrease in urination
  • dizziness (severe) or fainting
  • drowsiness
  • fast or irregular heartbeat
  • nausea and vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Diarrhea
  • hardening or thickening of the skin where the needle is placed
  • loss of appetite

Less common

  • Dizziness or lightheadedness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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