Generic Name: iopamidol (Injection route)
Commonly used brand name(s)
In the U.S.
- Isovue-M 200
- Isovue-M 300
Available Dosage Forms:
Therapeutic Class: Radiological Non-Ionic Contrast Media
Uses For Isovue-300
Iopamidol injection is used to help diagnose or find problems in the brain, heart, head, blood vessels, and other parts of the body. It is an iodinated contrast agent. Contrast agents are used to create a clear picture of the different parts of the body during certain medical procedures such as CT scans and angiography.
This medicine is to be given only by or under the supervision of a doctor.
Before Using Isovue-300
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of iopamidol injection in children. However, children are more likely to have side effects, which may require caution in patients receiving this medicine.
Appropriate studies on the relationship of age to the effects of iopamidol injection have not been performed in the geriatric population. However, no geriatric-specific problems have been documented to date.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Allergic rhinitis (hay fever) or
- Allergy to a contrast agent, history of or
- Allergy to iodine or
- Asthma—Use with caution. May increase risk of having allergic reactions.
- Anuria (not able to pass urine) or
- Blood vessel disease, severe or
- Congestive heart failure or
- Dehydration or
- Diabetes or
- Diabetic nephropathy or
- Kidney disease or
- Multiple myeloma (cancer of plasma cells) or
- Paraproteinemia (high amount of paraprotein in the blood)—May increase risk of having kidney failure.
- Blood clotting problems (eg, phlebitis, thrombosis) or
- Heart or blood vessel disease (eg, arteriosclerosis) or
- Hyperthyroidism (overactive thyroid) or
- Kidney disease, severe or
- Liver disease or
- Myasthenia gravis or
- Pheochromocytoma (adrenal problem) or
- Pulmonary hypertension or
- Sickle cell anemia (inherited blood disorder)—Use with caution. May make these conditions worse.
- Homocystinuria (genetic disease)—Patients with this condition should avoid undergoing angiography because of the increase risk of having blood clotting problems.
Proper Use of iopamidol
This section provides information on the proper use of a number of products that contain iopamidol. It may not be specific to Isovue-300. Please read with care.
A doctor or other trained health professional will give you or your child this medicine in a hospital. This medicine is given through a needle placed in an artery or a vein.
Drink extra fluids so you will pass more urine while you or your child are receiving this medicine. This may help prevent kidney problems.
Precautions While Using Isovue-300
It is very important that your doctor check the progress of you or your child closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.
This medicine may cause heart attack, stroke, and blood clotting problems during angiographic procedures. Tell your doctor right away if you or your child has chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, nausea, unusual sweating, faintness, coughing up blood, numbness or weakness in your arm or leg, or on one side of your body, sudden or severe headache, or problems with vision, speech, or walking after receiving this medicine.
Severe kidney problems may occur after receiving this medicine. This is more likely to occur if you receive too much of this medicine. Tell your doctor right away if you or your child have the following symptoms after receiving the medicine: agitation, confusion, decreased urine output, dizziness, headache, muscle twitching, rapid weight gain, or swelling of the face, ankles, or hands.
This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor or nurse right away if you or your child has a skin rash, itching, shortness of breath, sweating, swelling of the face, tongue, and throat, or tightness in the chest after you get the injection.
Tell your doctor right away if you or your child has mild, burning pain, feeling of warmth or coldness, peeling of the skin, redness, or swelling at the injection site.
Make sure your doctor knows if you or your child have had an allergic reaction to any dye or medicine given during a test or procedure.
While using this medicine, you may be exposed to radiation. Talk with your doctor if you have concerns about this.
Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Isovue-300 Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:Less common
- Arm, back, or jaw pain
- blurred vision
- chest pain or discomfort
- chest tightness or heaviness
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fast or irregular heartbeat
- feeling of warmth
- lightheadedness, dizziness, or fainting
- redness of the face, neck, arms, and occasionally, upper chest
- shortness of breath
- slow or irregular heartbeat
- sudden sweating
- unusual tiredness or weakness
- Blue lips and fingernails
- changes in skin color
- coughing that sometimes produces a pink frothy sputum
- decrease in the frequency of urination
- decrease in urine volume
- difficult, fast, noisy breathing, sometimes with wheezing
- difficulty in passing urine (dribbling)
- fast, pounding, or irregular heartbeat or pulse
- hives or welts, itching, or skin rash
- increased sweating
- numbness or tingling in the face, arms, or legs
- pain or discomfort in the arms, jaw, back, or neck
- pain, tenderness, or swelling of the foot or leg
- painful urination
- pale skin
- pounding in the ears
- redness of the skin
- severe, unusual tiredness or weakness
- trouble speaking, thinking, or walking
- Double vision
- inability to move the arms, legs, or facial muscles
- pain in the chest, groin, or legs, especially the calves
- severe, sudden headache
- slow speech
- slurred speech
- sudden loss of coordination
- sudden, severe weakness or numbness in the arm or leg
- sudden, unexplained shortness of breath
- vision changes
- Change in consciousness
- heart stops
- loss of consciousness
- no breathing
- no pulse or blood pressure
- no sensation in the legs
- not able to pass urine
- pain, redness, or pale skin at the injection site
- unable to move the legs
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less common or rare
- Bad, unusual, or unpleasant (after) taste
- change in taste
- disturbed color perception
- feeling sad or empty
- halos around lights
- loss of appetite
- loss of interest or pleasure
- loss of vision
- night blindness
- overbright appearance of lights
- stuffy nose
- trouble concentrating
- trouble sleeping
- tunnel vision
- weight loss
- Abdominal or stomach cramps
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- burning, dry, or itching eyes
- discharge or excessive tearing
- general feeling of discomfort or illness
- loss of memory
- problems with memory
- redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
- runny nose
- trembling or shaking of the hands or feet
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
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