carfilzomib (Intravenous route)Pronunciation
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
- Powder for Solution
Therapeutic Class: Antineoplastic Agent
Pharmacologic Class: Proteasome Inhibitor
Uses For carfilzomib
Carfilzomib injection is used alone or together with other medicines (eg, dexamethasone, lenalidomide) to treat multiple myeloma (a type of bone marrow cancer) in patients who have received other treatments that did not work well. It interferes with the growth of cancer cells, which are eventually destroyed by the body. Carfilzomib is an antineoplastic agent (cancer medicine).
carfilzomib is to be given only by or under the supervision of your doctor.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, carfilzomib is used in certain patients with the following medical conditions:
- Waldenstrom macroglobulinemia (a rare type of slow growing non-Hodgkin lymphoma).
Before Using carfilzomib
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For carfilzomib, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to carfilzomib or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of carfilzomib injection in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of carfilzomib injection in the elderly.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving carfilzomib, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using carfilzomib with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Measles Virus Vaccine, Live
- Mumps Virus Vaccine, Live
- Rubella Virus Vaccine, Live
- Varicella Virus Vaccine
Using carfilzomib with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Adenovirus Vaccine
- Bacillus of Calmette and Guerin Vaccine, Live
- Cholera Vaccine, Live
- Influenza Virus Vaccine, Live
- Poliovirus Vaccine, Live
- Smallpox Vaccine
- Typhoid Vaccine
- Yellow Fever Vaccine
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of carfilzomib. Make sure you tell your doctor if you have any other medical problems, especially:
- Angina or
- Blood clots or
- Cardiomyopathy (heart disease) or
- Congestive heart failure or
- Deep vein thrombosis (blood clot in leg) or
- Heart attack, recent or
- Heart disease or
- Hypertension (high blood pressure) or
- Interstitial lung disease or
- Kidney disease or
- Liver disease or
- Lung or breathing problems or
- Pneumonitis (lung inflammation) or
- Pulmonary edema (lung disease) or
- Pulmonary embolism (blood clot in lung) or
- Pulmonary hypertension (lung disease) or
- Thrombocytopenia (low platelets in the blood)—Use with caution. May make these conditions worse.
Proper Use of carfilzomib
A nurse or other trained health professional will give you carfilzomib in a hospital or cancer clinic. carfilzomib is given through a needle placed in a vein.
carfilzomib needs to be given on a fixed schedule. Be sure to keep all appointments.
Drink extra fluids so you will pass more urine while you are receiving carfilzomib. This may help prevent kidney problems and other unwanted effects.
You might also receive medicines (eg, dexamethasone) to help prevent unwanted reactions to the injection.
Precautions While Using carfilzomib
It is very important that your doctor check you at regular visits while you are receiving carfilzomib to make sure that the medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.
Using carfilzomib while you are pregnant can harm your unborn baby. Use an effective form of birth control during treatment and for at least 30 days after the last dose to keep from getting pregnant. Male patients must also use an effective form of birth control to prevent pregnancy in a sexual partner during treatment and for at least 90 days after the last dose. If you think a pregnancy has occurred with carfilzomib, tell your doctor right away.
carfilzomib may cause serious heart problems. Tell your doctor right away if you have chest pain or discomfort, shortness of breath, irregular heartbeats, or swelling of the feet, ankles, or legs while you are receiving carfilzomib.
Kidney problems may occur while you are receiving carfilzomib. Tell your doctor if you have the following symptoms: agitation, confusion, decreased urine output, depression, headache, rapid weight gain, swelling the face, ankles, or hands, or unusual tiredness or weakness.
carfilzomib may cause a serious reaction called tumor lysis syndrome (TLS). Call your doctor right away if you have a change in how much or how often you urinate, rapid weight gain, muscle or joint pain, swelling of the feet or lower legs, or feel tired.
Blood clots may occur while you are receiving carfilzomib. Tell your doctor right away if you have chest pain, dizziness or lightheadedness, fainting, fast heartbeat, pain, redness, or swelling in the arm or legs, sudden shortness of breath, trouble breathing.
carfilzomib may cause you to be more dizzy, lightheaded, or tired than normal. Make sure you know how you react to carfilzomib before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert. Getting up slowly from a sitting or lying position may help prevent lightheadedness or dizziness. Tell your doctor if you feel dizzy or lightheaded.
carfilzomib may cause a serious type of allergic reaction called an infusion reaction. This can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a cough, difficulty with swallowing, dizziness, a fast heartbeat, chest tightness, trouble breathing, swelling in your face or hands, a fever, chills, itching or hives, or lightheadedness or faintness while you are receiving carfilzomib.
carfilzomib can lower the number of platelets in your blood, which are needed for blood clotting. Check with your doctor right away if you notice any unusual bleeding or bruising, black, tarry stools, or pinpoint red spots on your skin.
Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.
Tell your doctor right away if you have seizures, headache, confusion, vision problems, unusual drowsiness, tiredness, or weakness. These could be symptoms of a serious nervous system problem called posterior reversible encephalopathy syndrome (PRES).
carfilzomib Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:More common
- black, tarry stools
- bleeding gums
- bloating or swelling of the face, arms, hands, lower legs, or feet
- blood in the urine or stools
- blurred vision
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- chest pain
- cough or hoarseness
- decreased urine output
- difficult or labored breathing
- difficulty with moving
- fast or irregular heartbeat
- irregular heartbeat
- lower back or side pain
- muscle spasms (tetany) or twitching
- nausea or vomiting
- numbness or tingling in the hands, feet, or lips
- painful or difficult urination
- pale skin
- pinpoint red spots on the skin
- pounding in the ears
- rapid weight gain
- slow or fast heartbeat
- tightness in the chest
- tingling of the hands or feet
- troubled breathing with exertion
- ulcers, sores, or white spots in the mouth
- unsteadiness or awkwardness
- unusual bleeding or bruising
- unusual tiredness or weakness
- unusual weight gain or loss
- muscle pain or cramps
- painful blisters on the trunk of the body
- weakness in the arms, hands, legs, or feet
- Dark-colored urine
- general feeling of discomfort or illness
- general feeling of tiredness or weakness
- light-colored stools
- stomach pain, continuing
- thickening of bronchial secretions
- yellow eyes or skin
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- joint pain, stiffness, or swelling
- stomach pain
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Back pain
- body aches or pain
- bone pain
- dry mouth
- ear congestion
- flushed, dry skin
- fruit-like breath odor
- increased hunger
- increased thirst
- increased urination
- loss of appetite
- loss of voice
- metallic taste
- muscle weakness
- pain in the arms or legs
- runny nose
- sore throat
- trouble sleeping
- weight loss
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
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