Comparing Spironolactone vs Medroxyprogesterone
Spironolactone | Medroxyprogesterone |
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Spironolactone | Medroxyprogesterone |
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Prescription only
Spironolactone is a diuretic that may be used to remove excess fluid (edema) from the body, lower blood pressure, or treat hyperaldosteronism. It does not cause potassium loss from the body; however... View more |
Prescription only
Prescribed for Abnormal Uterine Bleeding, Endometrial Hyperplasia - Prophylaxis, Amenorrhea, Endometrial Cancer, Birth Control, Endometriosis, Gender Affirming Hormone Therapy , Gender Dysphoria... View more |
Related suggestions |
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More about Spironolactone | More about Medroxyprogesterone | ||||||||||||||||
Ratings & Reviews | |||||||||||||||||
Spironolactone has an average rating of 6.9 out of 10 from a total of 696 ratings on Drugs.com. 59% of reviewers reported a positive effect, while 24% reported a negative effect. |
Medroxyprogesterone has an average rating of 4.6 out of 10 from a total of 2466 ratings on Drugs.com. 31% of reviewers reported a positive effect, while 51% reported a negative effect. |
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Drug Class | |||||||||||||||||
Side Effects | |||||||||||||||||
See also: spironolactone side effects in more detail. |
See also: medroxyprogesterone side effects in more detail. |
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Generic Availability | |||||||||||||||||
Lower cost generic |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all spironolactone prices |
View all medroxyprogesterone prices |
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Dosage Forms Available | |||||||||||||||||
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Brand Names | |||||||||||||||||
Aldactone, CaroSpir | Depo Provera, depo-subQ provera 104, Provera | ||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
37 hours |
401 hours |
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CSA Schedule ** View glossary of terms | |||||||||||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | |||||||||||||||||
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||||||||||
A total of 383 drugs are known to interact with spironolactone:
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A total of 244 drugs are known to interact with medroxyprogesterone:
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Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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Disease Interactions | |||||||||||||||||
First Approval Date | |||||||||||||||||
January 21, 1960 |
June 18, 1959 |
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WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
N/A |
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More Information | |||||||||||||||||
Patient resources | |||||||||||||||||
Professional Resources | |||||||||||||||||
Related Treatment Guide | |||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.