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Comparing Prograf vs Rapamune

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Prograf Remove Prograf from your drug comparison Rapamune Remove Rapamune from your drug comparison
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Prograf tacrolimus Remove Prograf from your drug comparison Rapamune sirolimus Remove Rapamune from your drug comparison

Prescribed for Organ Transplant - Rejection Reversal, Organ Transplant - Rejection Prophylaxis. Prograf may also be used for purposes not listed in this medication guide.

Prescribed for Lymphangioleiomyomatosis, Organ Transplant - Rejection Prophylaxis. Rapamune may also be used for purposes not listed in this medication guide.

Prescription only

Prescription only

Ratings & Reviews

View all 26 reviews

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Drug Class

Side Effects

Common side effects include: opportunistic infection, diabetes mellitus, infection, headache, hyperglycemia, hyperkalemia, increased blood urea nitrogen, increased serum creatinine, mental status changes, nephrotoxicity, sensation disorder, and tremor.

See the full Prograf side effects document.

Common side effects include: upper respiratory tract infection, and urinary tract infection.

See the full Rapamune side effects document.

Pricing and Coupons

* Prices are without insurance
Quantity 100 capsule
Dosage 1 mg
Per Unit* $6.39 - $6.58
Cost* $639.28 - $658.18

View all Prograf prices and generic prices

Quantity 100 tablet
Dosage 0.5 mg
Per Unit* $16.69
Cost* $1,668.53

View all Rapamune prices and generic prices

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Generic Availability

Yes

Yes

Dosage Form(s) Available
  • Intravenous solution
  • Oral capsule
  • Oral granule for reconstitution
  • Oral solution
  • Oral tablet

Brand Names
Other tacrolimus brands include: Astagraf XL, Envarsus XR

N/A

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

21.2 hours

78 hours

CSA Schedule**

View glossary of terms.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category
C
Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.
C
Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

FDA Alerts

FDA Alerts (1)

FDA Alerts (5)

Drug Interactions

A total of 739 drugs are known to interact with Prograf:

  • 226 major drug interactions (820 brand and generic names)
  • 496 moderate drug interactions (1855 brand and generic names)
  • 17 minor drug interactions (129 brand and generic names)

A total of 587 drugs are known to interact with Rapamune:

  • 162 major drug interactions (624 brand and generic names)
  • 417 moderate drug interactions (1578 brand and generic names)
  • 8 minor drug interactions (35 brand and generic names)

Alcohol/Food/Lifestyle Interactions
  • Tacrolimus should be taken on a consistent schedule before or after you eat at the same times each... View more
  • Grapefruit and grapefruit juice may interact with sirolimus and could lead to potentially dangerous... View more

Disease Interactions

First Approval Date

April 08, 1994

September 15, 1999

WADA Class

View World Anti-Doping Agency classifications.

N/A

N/A

More Information

Consumer Resources

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer