Comparing Osphena vs Prometrium
| Osphena (ospemifene) | Prometrium (progesterone) |
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| Osphena (ospemifene) | Prometrium (progesterone) |
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Prescription only
Prescribed for Vaginal Dryness, Atrophic Vaginitis, Postmenopausal Symptoms, Dyspareunia, Perimenopausal Symptoms. Osphena may also be used for purposes not listed in this medication guide. |
Prescription and OTC
Prescribed for Progesterone Insufficiency, Perimenopausal Symptoms, Uterine Bleeding, Amenorrhea, Endometrial Hyperplasia - Prophylaxis, Premature Labor. Prometrium may also be used for purposes not... View more |
Related suggestions Perimenopausal Symptoms
Popular comparisons
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| More about Osphena (ospemifene) | More about Prometrium (progesterone) | ||||||||
| Ratings & Reviews | |||||||||
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Osphena has an average rating of 5.3 out of 10 from a total of 45 ratings on Drugs.com. 36% of reviewers reported a positive effect, while 40% reported a negative effect. |
Prometrium has an average rating of 7.0 out of 10 from a total of 37 ratings on Drugs.com. 57% of reviewers reported a positive effect, while 16% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||
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View all Osphena side effects |
View all Prometrium side effects |
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| Drug Class | |||||||||
| Generic Availability | |||||||||
| Pricing and Coupons * Prices are without insurance | |||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Prometrium prices |
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| Dosage Forms | |||||||||
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| Brand Names | |||||||||
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N/A |
Other progesterone brands include: Crinone, Cyclogest, Endometrin, First Progesterone MC10, First Progesterone MC5, Gestone, Milprosa | ||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||
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26 hours |
1 hour |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category B
No proven risk in humans
Oral Formulations
Category N
Not classified
Excluding Oral Formulations See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||
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A total of 98 drugs are known to interact with Osphena:
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A total of 222 drugs are known to interact with Prometrium:
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| Alcohol/Food/Lifestyle Interactions | |||||||||
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| Disease Interactions | |||||||||
| First Approval Date | |||||||||
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February 26, 2013 |
N/A |
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| WADA Class View classifications | |||||||||
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N/A |
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| More Information | |||||||||
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| Related Treatment Guide | |||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.