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Osphena (ospemifene) Disease Interactions

There are 4 disease interactions with Osphena (ospemifene):


Ospemifene (Includes Osphena) ↔ Breast Cancer

Severe Potential Hazard, Moderate plausibility

Applies to: Neoplasia -- Estrogen Dependent

Ospemifene has not been adequately studied in women with breast cancer, therefore should not be used in women with known, suspected or with a history of breast cancer. Additionally, ospemifene is contraindicated in the presence of any known or suspected estrogen-dependent neoplasia.


Ospemifene (Includes Osphena) ↔ Cardiovascular Disorders

Severe Potential Hazard, Moderate plausibility

Applies to: Cardiovascular Disease, Smoking, Hyperlipidemia, Lupus Erythematosus

There is a reported increase of stroke and deep vein thrombosis (DVT) in postmenopausal women receiving oral conjugated estrogens. Ospemifene should be prescribed for the shortest duration consistent with treatment goals, weighting risks and benefits for each woman. Ospemifene is contraindicated in women with active DVT, pulmonary embolism, active arterial thromboembolic disease (such as stroke or myocardial infarctions), or a history of any of these conditions. Other risk factors for cardiovascular disorders and/or venous thromboembolism such as hypertension, diabetes, smoking, hypercholesterolemia, obesity, lupus erythematosus (in personal or family history), should be evaluated and managed appropriately.


Ospemifene (Includes Osphena) ↔ Genital Bleeding

Severe Potential Hazard, Moderate plausibility

Applies to: Abnormal Uterine Bleeding

The use of ospemifene is contraindicated in women with any undiagnosed abnormal genital bleeding. There is an increased risk of endometrial hyperplasia and endometrial cancer in patients using estrogens. Adequate diagnostic measures should be undertaken to rule out malignancy in any postmenopausal woman with undiagnosed persistent or recurring abnormal genital bleeding.


Ospemifene (Includes Osphena) ↔ Severe Hepatic Impairment

Severe Potential Hazard, Moderate plausibility

Applies to: Liver Disease

Ospemifene should not be used in women with severe hepatic impairment, as the pharmacokinetics have not been studied in these patients. No clinically important differences were observed in women with mild to moderate hepatic impairment when compared to healthy women, therefore no dose adjustment is needed in these patients.

Osphena (ospemifene) drug Interactions

There are 115 drug interactions with Osphena (ospemifene)

Osphena (ospemifene) alcohol/food Interactions

There are 2 alcohol/food interactions with Osphena (ospemifene)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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