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Comparing Orkambi vs Trikafta

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Orkambi (ivacaftor / lumacaftor) Trikafta (elexacaftor / ivacaftor / tezacaftor)
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Orkambi (ivacaftor / lumacaftor) Trikafta (elexacaftor / ivacaftor / tezacaftor)
Prescription only

Prescribed for Cystic Fibrosis. Orkambi may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Cystic Fibrosis. Trikafta may also be used for purposes not listed in this medication guide.

Related suggestions
More about Orkambi (ivacaftor / lumacaftor) More about Trikafta (elexacaftor / ivacaftor / tezacaftor)
Ratings & Reviews

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Trikafta has an average rating of 9.0 out of 10 from a total of 1 ratings on Drugs.com. 100% of reviewers reported a positive effect, while 0% reported a negative effect.

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View all 1 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Orkambi side effects

View all Trikafta side effects
Drug Class
Generic Availability

No lower cost generic approved

N/A
Pricing and Coupons * Prices are without insurance
Quantity 56 granule for reconstitution
Strength 94 mg-75 mg
Per unit* $443.18
Cost* $24,818.08

View all Orkambi prices

Quantity 56 each
Strength 80 mg-60 mg-40 mg and ivacaftor 59.5 mg
Per unit* $506.22
Cost* $28,348.39

View all Trikafta prices

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Dosage Forms
  • Oral granule for reconstitution
  • Oral tablet
  • Oral granule
  • Oral tablet
Brand Names

N/A

N/A
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

26 hours

60.3 hours
CSA Schedule 1 View glossary of CSA terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
B
Category B No proven risk in humans

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.
Drug Interactions

A total of 572 drugs are known to interact with Orkambi:

  • 256 major drug interactions (770 brand and generic names)
  • 303 moderate drug interactions (1246 brand and generic names)
  • 13 minor drug interactions (28 brand and generic names)

A total of 486 drugs are known to interact with Trikafta:

  • 101 major drug interactions (344 brand and generic names)
  • 368 moderate drug interactions (1386 brand and generic names)
  • 17 minor drug interactions (38 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Ivacaftor should be taken with fat-containing foods such as eggs, avocados, nuts, meat, butter... View more
  • Ivacaftor should be taken with fat-containing foods such as eggs, avocados, nuts, meat, butter... View more
Disease Interactions
First Approval Date

July 02, 2015

N/A
WADA Class View classifications

N/A

N/A
More Information
Patient Resources
Professional Resources
Related Treatment Guide

1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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