Comparing Melatonin vs ZzzQuil
| Melatonin | ZzzQuil (diphenhydramine) |
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| Melatonin | ZzzQuil (diphenhydramine) |
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|---|---|---|
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Prescription and OTC
Supplemental melatonin is very effective at reducing symptoms of jet lag, particularly that brought about by eastward travel across five or more time zones. Melatonin may also be used to treat sleep... View more |
Prescription and OTC
Prescribed for Insomnia. ZzzQuil may also be used for purposes not listed in this medication guide. |
Related suggestions Insomnia
Popular comparisons
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| More about Melatonin | More about ZzzQuil (diphenhydramine) | |
| Ratings & Reviews | ||
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Melatonin has an average rating of 5.7 out of 10 from a total of 239 ratings on Drugs.com. 44% of reviewers reported a positive effect, while 37% reported a negative effect. |
ZzzQuil has an average rating of 2.9 out of 10 from a total of 68 ratings on Drugs.com. 16% of reviewers reported a positive effect, while 72% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||
View all Melatonin side effects |
View all ZzzQuil side effects |
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| Drug Class | ||
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None |
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| Generic Availability | ||
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N/A |
N/A |
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| Pricing and Coupons * Prices are without insurance | ||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
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| Dosage Forms | ||
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N/A |
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| Brand Names | ||
| Bio-Melatonin, Melatonin Time Release, SGard, Sleep3 | Other diphenhydramine brands include: Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Aurodryl Children's Allergy, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep View more | |
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||
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N/A |
9.3 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||
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Category N
Not classified
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | ||
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A total of 342 drugs are known to interact with Melatonin:
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A total of 448 drugs are known to interact with ZzzQuil:
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| Alcohol/Food/Lifestyle Interactions | ||
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| Disease Interactions | ||
| First Approval Date | ||
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N/A |
N/A |
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| WADA Class View classifications | ||
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N/A |
N/A |
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| More Information | ||
| Patient Resources | ||
| Professional Resources | ||
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N/A |
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| Related Treatment Guide | ||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.