Comparing Mekinist vs Tafinlar

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Mekinist trametinib

Tafinlar dabrafenib

Prescribed for Melanoma - Metastatic, Thyroid Cancer, Non-Small Cell Lung Cancer. Mekinist may also be used for purposes not listed in this medication guide.

Prescribed for Thyroid Cancer, Melanoma - Metastatic, Non-Small Cell Lung Cancer. Tafinlar may also be used for purposes not listed in this medication guide.

Prescription only

Ratings & Reviews

View all 1 reviews

View all 2 reviews

Drug Class

Multikinase inhibitors

Multikinase inhibitors

Side Effects

Common side effects include: acneiform eruption, cardiomyopathy, decreased left ventricular ejection fraction, dermatitis, palmar-plantar erythrodysesthesia, skin rash, and erythema of skin.

See the full Mekinist side effects document.

Common side effects include: squamous cell carcinoma, fever, and hyperglycemia.

See the full Tafinlar side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	30 tablet
Dosage	0.5 mg
Per Unit^*	$129.16
Cost^*	$3,874.69

View all Mekinist prices

Quantity	120 capsule
Dosage	50 mg
Per Unit^*	$78.43
Cost^*	$9,411.28

View all Tafinlar prices

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Generic Availability

Dosage Form(s) Available

Oral tablet

Oral capsule

Brand Names

N/A

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

115.2 hours

22 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category D Positive evidence of risk

See the full Pregnancy Warnings document.

Category D Positive evidence of risk

See the full Pregnancy Warnings document.

Drug Interactions

A total of 15 drugs are known to interact with Mekinist:

15 moderate drug interactions (30 brand and generic names)

A total of 426 drugs are known to interact with Tafinlar:

57 major drug interactions (189 brand and generic names)
359 moderate drug interactions (1483 brand and generic names)
10 minor drug interactions (33 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Food may delay and reduce the absorption of trametinib, which may lead to lower blood levels of the... View more

Food may delay and reduce the absorption of dabrafenib, which may lead to lower blood levels of the... View more

Disease Interactions

First Approval Date

May 29, 2013

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

Consumer Resources

Advanced Reading

Advanced Reading

Professional Resources

Prescribing Information

Prescribing Information

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer