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Pancrelipase and Gas: What Users Say

Brand names: Creon, Zenpep, Pancreaze, Viokace, Pertzye

Gas: mentioned by 3 users (3.3%)

Based on user experiences from 92 Pancrelipase reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

diarrhea 21.7%
bloating 9.8%
abdominal pain 5.4%
headaches 5.4%
nausea 4.3%
vomiting 4.3%
anxiety 3.3%
brain fog 3.3%
cramps 3.3%
gas 3.3%

Reviews for Pancrelipase

Commonly mentioned side effects
  • Sue...
  • Taken for 1 to 2 years
  • May 22, 2017

For Pancreatic Exocrine Dysfunction "I was diagnosed 2 years ago with stage 4 pancreatic cancer. I have had chemo and radiation, and I am doing very well. When first diagnosed, I was on Creon. I had no side effects, but wanted something a little less expensive, so my oncologist suggested I try Zenpep. It works great, as long as I don't forget and skip a dose. When I skip a dose, all my symptoms come roaring back: gas, pain, cramps, and loose bowels."

9 / 10
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52 Report
  • cra...
  • Taken for 1 to 2 years
  • February 29, 2020

For Pancreatic Exocrine Dysfunction "I take Creon 25000 (2 with meals, 1 with snacks) because I take Somatulin for NET tumors, and it upsets pancreatic function. Originally wasn't impressed, so after 4 months, with my doctor's OK, I suspended it... but the symptoms came back in spades. I'm now more religious about dosage and timing and find it helps immensely (back on it 8 months). Helps with gas, bloating, diarrhea, greasy stools, smell. Not always totally effective, but I haven't restricted what I eat or drink and suppose if I were better at that, I'd have more success. Good luck to others!"

8 / 10
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34 Report
  • Dav...
  • Taken for less than 1 month
  • July 5, 2025

For Pancreatic Exocrine Dysfunction "I’ve had years (10+) of loose stools, becoming worse over the past 18 months; indigestion, nausea, gassy, bloated, foamy, sticky, oily, often undigested food. After fecal elastase (139) & scans/tests previously diagnosed with idiopathic EPI. Started Creon recently; (initially 50,000 per meal, 25,000 snacks - Gastro increased to 75,000 & 50,000) indigestion calmed, stools a lot firmer (still very soft at times), less greasy, bloating noticeably down, no oil film in toilet, and no undigested food!"

10 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.