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Hizentra and Headaches: What Users Say

Headaches: mentioned by 4 users (11.8%)

Based on user experiences from 34 Hizentra reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

headaches 11.8%
nausea 11.8%
swelling 11.8%
fatigue 8.8%
pain 8.8%

Reviews for Hizentra

Commonly mentioned side effects
  • Aug...
  • Taken for less than 1 month
  • March 30, 2018

For Primary Immunodeficiency Syndrome "I just had my third subcutaneous infusion of Hizentra. I have had a few side effects, such as itching at injection sites only on the first infusion. Today, I had a small headache and heartburn. I was easily able to treat this with OTC meds. But the good news is I am able to do things I love for the first time in 15 years. Don’t wait to get this med started. I hope you will be a success story too!"

10 / 10
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38 Report
  • Clo...
  • Taken for 6 months to 1 year
  • August 11, 2017

For Primary Immunodeficiency Syndrome "I was on Hizentra and never felt well - ever! During infusion, I would immediately become nauseated. Shortly thereafter, I would experience a horrible headache. My pre-medications were Zofran, Zomig (for my migraine problems), Tylenol, and Benadryl. My trough level was at a decent level, so I was able to have my sinus surgery. I had post-sinus infections of 3 different bacteria. I just kept getting sicker and sicker. Hizentra was the worst drug interactions ever put into my body for 8 months!"

2 / 10
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20 Report
  • gab...
  • Taken for 1 to 6 months
  • June 3, 2023

For Primary Immunodeficiency Syndrome "I've had Hizentra on and off for 4 months. Every time I start the treatment with only 2 grams, when I got to 4 grams, the symptoms were terrible: nausea, lack of appetite, high blood pressure, debilitating headaches, etc. The worst part was being told by my doctor that these symptoms could not happen with Hizentra and now reading all your reviews! Thank you for sharing!"

3 / 10
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5 Report
  • Jos...
  • Taken for 6 months to 1 year
  • July 20, 2025

For Primary Immunodeficiency Syndrome "Overall, I have had the desired results. Since beginning treatment, I have had no further issues of unresolved infection. Any abrasions or illnesses have resolved themselves without the use of antibiotics. The side effects, however, have seemed to slowly increase in numbers and severity. My wife believes I am exaggerating them, but I am not! The number of headaches has increased, but not the severity. The tinnitus has dramatically increased in frequency and intensity. Bouts of recurring nausea increased. Extreme fatigue sometimes for days. Terrible itching and irritation at times. Bloating. Shortness of breath and dizziness at times. Palpitations and racing sensations. Blurry eyes very often. Occasional confusion. And multiple urination issues with back pain."

7 / 10
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0 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.