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Mucinex D and Tiredness: What Users Say

Tiredness: mentioned by 9 users (4.0%)

Based on user experiences from 224 Mucinex D reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

insomnia 29.0%
anxiety 23.7%
increased heart rate 10.3%
nausea 5.8%
tremors 5.8%
drowsiness 5.4%
cough 4.5%
dizziness 4.5%
tiredness 4.0%
dry mouth 3.6%

Reviews for Mucinex D

Commonly mentioned side effects
  • Sin...
  • Taken for less than 1 month
  • April 14, 2013

For Cough and Nasal Congestion "I have suffered from allergic rhinitis all my life: dry, swollen sinus; sinus pressure; headaches; blurry vision; dizziness; lethargy; all sorts of cognitive problems because of the lack of oxygen to my body and brain due to thickened mucus in my respiratory system; not to mention frequent bacterial infections due to accumulated mucus secretions. I had tried every other medicine under the sun. Mucinex has taken all that away, and my quality of life has improved 150%. I strongly recommend Mucinex for those with sinus problems due to allergic rhinitis, or anyone who suffers from sinus or any sort of respiratory congestion."

10 / 10
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37 Report
  • KCM...
  • February 14, 2016

For Cough and Nasal Congestion "Awful. Yes, this medication did clear up my cough, BUT the side effects were awful! I was extremely jittery, lethargic, anxious, and then became nauseous as well. I would not take this medication again."

1 / 10
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17 Report
  • Amb...
  • September 20, 2016

For Cough and Nasal Congestion "Took this with food. Made me feel very lethargic and jittery at the same time. My appetite is gone. My congestion is cleared, but I can't wait for this medication to wear off. My heart rate speeds up as well. Dry mouth, yuck."

4 / 10
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11 Report

Frequently asked questions

  • Sha...
  • November 24, 2016

For Cough and Nasal Congestion "I took Mucinex, the capsule, as directions state, to help me with severe congestion the night before Thanksgiving. After reading the reviews, I must say it had the opposite effect on me, it made me tired. The best way for me to describe it was I felt like I took a muscle relaxer, but not as strong. It just made me feel slightly weak and needed to sleep. Although it definitely helped relieve my symptoms from being congested, such as my headache and cough. So for my sake, I would want to take it at night and definitely not have to drive anywhere. I am not one to take medication or any drugs for that matter."

9 / 10
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9 Report
  • Anonymous
  • October 13, 2010

For Cough and Nasal Congestion "Love this product. I've used Mucinex before for cough congestion, and I didn't feel that worked at all for me, but Mucinex D has already offered me much relief from my sinus infection. I couldn't breathe through my nose at all, and within 3 1/2 hours, I feel better and can breathe. I took this with 2 Excedrin Back and Body for the severe tender/nose pain and feel relieved and comfortable. Still tired (no insomnia here; 600/600 mg dosage) and ready to finally get some sleep."

10 / 10
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5 Report

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  • col...
  • March 11, 2009

For Cough and Nasal Congestion "I used this medication and had none of the insomnia or restlessness. I had the exact opposite reaction. I had been dealing with a sinus cold and was getting headaches from them. After using over-the-counter medication to combat the headaches, I went to the doctor who prescribed Mucinex D because he said it was much more powerful. Long story short, I couldn't make it through a day of work without sleeping. I at first related it to the cold, but when I halved my dosage, I was still tired but not to the point of exhaustion when I took two pills. As of now, my pills are gone and I don't feel tired in the least. Insomnia I can handle, falling asleep on the job I can't."

3 / 10
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6 Report
  • col...
  • March 11, 2009

For Cough and Nasal Congestion "I used this medication and had none of the insomnia or restlessness. I had the exact opposite reaction. I had been dealing with a sinus cold and was getting headaches from them. After using over-the-counter medication to combat the headaches, I went to the doctor who prescribed Mucinex D because he said it was much more powerful. Long story short, I couldn't make it through a day of work without sleeping. I at first related it to the cold, but when I halved my dosage, I was still tired but not to the point of exhaustion when I took two pills. As of now, my pills are gone and I don't feel tired in the least. Insomnia I can handle, falling asleep on the job I can't."

3 / 10
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6 Report

More FAQ

  • Pam...
  • July 16, 2014

For Cough and Nasal Congestion "It works, but it's the pseudoephedrine that keeps you awake all night, tossing and turning, and I had that for about three days. I was physically exhausted but wide awake."

6 / 10
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40 Report
  • don...
  • Taken for less than 1 month
  • July 2, 2014

For Cough and Nasal Congestion "I wish I would have read this before I had taken it. I have been awake for over 24 hours! I've been sick for days and now can't sleep. Yes, I can breathe and less congestion, but now I'm exhausted."

9 / 10
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38 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.