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User Reviews for Acyclovir topical to treat Herpes Simplex

Also known as: Zovirax Cream, Zovirax Ointment

Acyclovir topical has an average rating of 8.6 out of 10 from a total of 14 ratings for the treatment of Herpes Simplex. 71% of reviewers reported a positive effect, while 7% reported a negative effect.

Acyclovir topical Rating Summary

8.6/10 average rating

14 ratings from 14 user reviews.

Compare all 45 medications used in the treatment of Herpes Simplex.

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Reviews for Acyclovir topical

iamasurvivoraol March 30, 2010

Zovirax Ointment (acyclovir): “I've been using this product for years. It's the best thing to not having an outbreak. You must catch it on the first sign though, when the tingling begins if possible. After that it will run its full course in pain at the site. I have outbreaks frequently so I should know. I have trouble controlling when I have an OUTBREAK. I control how I can deal with it when it comes.”

9 / 10
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Nonie December 19, 2019

Zovirax Ointment (acyclovir): “There is some confusion about the cream vs. the ointment. Chemically, acyclovir is acyclovir. The only difference between the two is only the 'CARRIER' - cream vs ointment. The ointment (for genital herpes in U.S.) has polyethylene glycol, a very slippery compound used as in laxatives and for bowel prep. It has many other medical and industrial uses. Considering the small amount possibly ingested when applying to the mouth, the only reason not to use the cheaper ointment is if you are sensitive to polyethylene glycol. The cream (oral herpes/cold sores) contains mineral oil, (also a laxative) poloxamer 407, propylene glycol, sodium lauryl sulfate, water, and white petrolatum. Proplylene glycol is supposedly good for skin, stops flaking, etc. Despite hours of research I can't find why cream is so expensive unless maker thinks we'll pay more for a treatment for our face vs genitals. The CREAM is the one that is SO OUTRAGEOUSLY EXPENSIVE!!”

10 / 10
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Nick · Taken for 2 to 5 years August 12, 2020

“I have had cold sore outbreaks around my mouth since my childhood. I have tried absolutely everything (i.e. : Lipactin, Abreva and so on) and the only topical treatment I've found to be effective is acyclovir cream 5% (I buy generics). If applied early in the onset, sores typically remain small and will dry within a day or two. Before switching to acyclovir cream, an outbreak would last from 4 to 7 days. Now, 2 to 4 days is the usual. It feels like you are skipping the nasty and uncomfortable phase right after the outbreak to go straight to the "recovery" phase where the skin is healing under the dried scabs. I always carry some with me now.”

9 / 10
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Very satisfied! · Taken for 6 months to 1 year January 8, 2015

Zovirax Cream (acyclovir): “I have lived 14 years with cold sores from HSV 1, spending $20/tube on Abreva and suffering from annual break outs, some worse than others, but all embarrassing and painful! I never thought to ask for an prescfription, but coincidentally had a cold sore on my lip when I went to see my OBGYN last year. She noticed it and wrote me an Rx for Zovirax cream, and I let it sit in my wallet for a couple months until I felt the tell-tale "tingling". This stuff really works, and if you apply it early enough, the sore won't even really form or blister and will completely disappear within 3-5 days. It's amazing, and totally worth it. Do yourself a favor and get it! It was only $30, and the tube is bigger than a tube of Abreva.”

10 / 10
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Jamers · Taken for less than 1 month February 2, 2021

“I 100% recommend this acyclovir prescription/treatment to anyone suffering from herpes! I was diagnosed we with herpes simplex 1, and have used abreva, valtrex, and have tried random sworn by home remedies. Abreva after by maybe day 7 started to work, valtrex after close to a week began to work, the home remedies did not work at all!!! All in all, the effectiveness of what I've tried prior to acyclovir did not impress me as much as this prescription has. I was a day into my outbreak, my lip was already swollen and bubbled. That one day in I started the cream and the next day , it had gone down 80%. It was already scabbed over and no longer pulsating! This has definitely been a blessing to me, as I am very skeptical at times when it comes to medications that says to be close to 100% effective!”

10 / 10
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Justmakingendsmeet1 · Taken for 5 to 10 years January 30, 2017

Zovirax Cream (acyclovir): “I first contracted G. Herpes and where the semen contacted my skin and I've had eruptions of horrible painful blistering sores. It's first a tingle and I immediately know... I have Valtrex but it takes longer to work even if I take it at first tingle. For my cold sores I used to get sores on my chin, but no longer. I get them on my ear... uh huh that's right. My ear and the small of my back, right where my jeans hit. Once my ear swelled up so much and my neck too, nothing helped but this cream. It stopped my chin sores (underneath where a second neck would be if I had one) altogether. My back sores happen at severe stress, ugh, abreva doesn't help. This cream does 100% for me.”

10 / 10
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sickgirl168 October 31, 2015

Zovirax Ointment (acyclovir): “I have genital herpes as well as SLE and related complications. I mention the other health issues only because the treatment for the Lupus is to suppress the immune system, which can allow the herpes virus to become more active than it would be if my immune system was not compromised. I take valacyclovir daily for suppressive treatment, but when I do have an outbreak, I always add the acyclovir ointment. I find that it eases the discomfort and helps the sores heal a little bit faster.”

7 / 10
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ouchieee · Taken for less than 1 month November 26, 2017

“I was diagnosed with genital herpes earlier today, though the symptoms began a month ago and I mistaken it for a yeast infection. The sores started last Monday (5 days ago). The burning was so bad to the point where I had trouble walking. After applying acyclovir earlier I experienced moderate burning for a short amount of time but after sitting down for awhile I felt relief. let's hope that tomorrow the sores aren't as painful”

7 / 10
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Girl December 14, 2019

Zovirax Cream (acyclovir): “I have had a spot come up twice in 14 years on my index finger. Index finger on right hand, infected when worked as a dental assistant on patients. This time they prescribed this cream and I noticed a great change. You never know what you're exposed to in the medical/ dental field. Gloves still tear. But luckily they are Meds to help. This product has lessened the swelling and throbbing.”

7 / 10
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betterdays39 November 17, 2011

Zovirax Cream (acyclovir): “I got HSV-1 in 2008 from my cheating on my now ex-wife. It was never a problem until a breakout in 2010. I never went on antivirals until this breakout and I now know why this was so bad. In summer of 2010 I had neck surgery and had 4 fusions from c4-c7 and after reviewing this, the virus lies dormant in the base of the neck in nerve are called the ganglion. If you have HSV-2 (genital) herpes it lies in the lower back dormant. So, my first breakout 6 months ago in June 2011 gave me the worst ever making not only a cold sore but fever blister clusters on top and middle lip. Been on acyclovir since July 400mg twice daily. Still barely helped. 3 days ago got Zovirax cream and after 6 months its finally gone. This works awesome.”

10 / 10
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0326 January 23, 2017

“I have suffered from genital herpes for 6 years and tried all herbal prevention treantments as I suffer approximately 8 outbreaks a year. For the last 6 months I have tried the acyclovir suppressive treatment and in 6 months I have had 1 very mild outbreak. After the first 4 months I went from taking the recommended 2 tablets a day to just 1 a day. I am so glad I tried acyclovir, I feel I have my life back!”

10 / 10
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Anonymous · Taken for 2 to 5 years January 4, 2018

“I use the generic brand by Mylan. This product is amazing. Even if you have a bad outbreak it cuts the healing time by a few days. That may seem minimal to some, but those who suffer from cold sores, this is superb. If you apply it during the first signs you will not even have an outbreak.”

10 / 10
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Jb3lls September 3, 2015

“This is a god send. I was reluctant to pay the $400 since my insurance only covered the pills and not the ointment, but I'm really glad I did. My sore was looking very sinister and just kept growing until I put acyclovir cream on it. It dried up over night and is basically a scab now. It would normally take my sores weeks to go away completely, but from the looks of it now I think this will be gone in a few days. Totally worth the price for me because my work is very much dependant on my face. I was worried I wouldn't be able to work for a few weeks, but looks like I'll be back by Monday. (it's Thursday morning now. Sore started on Tuesday afternoon and I put the ointment on Wednesday morning).”

10 / 10
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Chris · Taken for less than 1 month May 5, 2020

“I was prescribed Acyclovir cream for face shingle treatment however I have no cold sores. I am in the scabbing phase. My dermatologist was negligent to tell me that the tiny tube would cost $230. This medication seems more designed for intense cold sores. Not sure its worth a damn if I don't have cold sores and not sure I am willing to spend $230 to see if it helps my scabs lighten. I don't hold dermatologists in high regard and now a bit less.”

1 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.

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