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Perflutren Lipid Microspheres

Generic name: Perflutren Lipid Microspheres [ per-FLOO-tren-LIPid-MI-kro-SFIRS ]
Brand name: Definity
Drug class: Ultrasound contrast media

Medically reviewed by Last updated on Apr 17, 2023.


  • Very bad heart or lung problems have rarely happened during or after infusion of this medicine (perflutren lipid microspheres). Sometimes these have been deadly. Most bad reactions happen within 30 minutes of the infusion. Talk with the doctor.

Uses of Perflutren Lipid Microspheres:

  • It is used before a heart imaging test.

What do I need to tell my doctor BEFORE I take Perflutren Lipid Microspheres?

  • If you are allergic to this medicine (perflutren lipid microspheres); any part of this medicine (perflutren lipid microspheres); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.

This medicine may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine (perflutren lipid microspheres) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Perflutren Lipid Microspheres?

  • Tell all of your health care providers that you take this medicine (perflutren lipid microspheres). This includes your doctors, nurses, pharmacists, and dentists.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this medicine (perflutren lipid microspheres) while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Perflutren Lipid Microspheres) best taken?

Use this medicine (perflutren lipid microspheres) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given into a vein for a period of time.
  • This medicine must not be given into an artery. Talk with the doctor.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of high or low blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
  • Chest pain or pressure.
  • A heartbeat that does not feel normal.
  • Shortness of breath.
  • Fast or slow heartbeat.
  • Seizures.
  • Numbness or tingling of the face.
  • Flushing.

What are some other side effects of Perflutren Lipid Microspheres?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if you have any side effects that bother you or do not go away.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Perflutren Lipid Microspheres?

  • If you need to store this medicine (perflutren lipid microspheres) at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer Information Use and Disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this medicine (perflutren lipid microspheres), please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.