Generic Name: Morphine and Naltrexone (MOR feen & nal TREKS one)
Brand Name: Embeda
Medically reviewed on Sep 5, 2018
- This medicine may be habit-forming with long-term use.
- This medicine is a strong pain drug that can put you at risk for addiction, abuse, and misuse. Misuse or abuse of morphine and naltrexone can lead to overdose and death. Talk with your doctor.
- You will be watched closely to make sure you do not misuse, abuse, or become addicted to morphine and naltrexone.
- Even one dose of morphine and naltrexone may be deadly if it is taken by someone else or by accident, especially in children. If morphine and naltrexone is taken by someone else or by accident, get medical help right away.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Do not take more than what your doctor told you to take. Taking more than you are told may raise your chance of very bad side effects.
- This medicine may cause very bad and sometimes deadly breathing problems. Call your doctor right away if you have slow, shallow, or trouble breathing.
- The chance of very bad and sometimes deadly breathing problems may be greater when you first start morphine and naltrexone or anytime your dose is raised.
- Swallow whole. Do not chew, break, crush, or melt before swallowing. Doing these things can cause very bad side effects and death.
- If you cannot swallow morphine and naltrexone whole, you may sprinkle the contents on applesauce. If you do this, swallow the mixture right away without chewing.
- This medicine has an opioid drug in it. The use of opioid drugs along with a benzodiazepine drug or other drugs that may make you drowsy or slow your actions has led to very bad side effects. Side effects that have happened include slowed or trouble breathing and deaths. Benzodiazepine drugs include drugs like alprazolam, diazepam, and lorazepam. Benzodiazepine drugs are used to treat many health problems like anxiety, trouble sleeping, or seizures. Talk with the doctor.
- Many drugs interact with morphine and naltrexone and can raise the chance of side effects like deadly breathing problems. Talk with your doctor and pharmacist to make sure it is safe to use morphine and naltrexone with all of your drugs.
- Do not take with alcohol or products that have alcohol. Unsafe and sometimes deadly effects may happen.
- Get medical help right away if you feel very sleepy, very dizzy, or if you pass out. Caregivers or others need to get medical help right away if the patient does not respond, does not answer or react like normal, or will not wake up.
- Using morphine and naltrexone for a long time during pregnancy may lead to withdrawal in the newborn baby. This can be life-threatening. Talk with the doctor.
Uses of Morphine and Naltrexone:
- It is used to ease very bad pain.
- It is only to be used when around-the-clock (continuous) care is needed for a long time. It is also only to be used when other pain drugs do not treat your pain well enough or you cannot take them.
What do I need to tell my doctor BEFORE I take Morphine and Naltrexone?
- If you have an allergy to morphine, naltrexone, or any other part of morphine and naltrexone.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have any of these health problems: Very bad asthma, trouble breathing, recent head injury, growths or tumors in the brain, raised pressure in the brain, or very bad bowel or stomach problems like bowel block.
- If you have taken certain drugs used for low mood (depression) like isocarboxazid, phenelzine, or tranylcypromine or drugs used for Parkinson's disease like selegiline or rasagiline in the last 14 days. Taking morphine and naltrexone within 14 days of those drugs can cause very bad high blood pressure.
- If you are taking any of these drugs: Linezolid or methylene blue.
- If you are taking any of these drugs: Buprenorphine, butorphanol, nalbuphine, or pentazocine.
- If you are breast-feeding. Do not breast-feed while you take morphine and naltrexone.
This is not a list of all drugs or health problems that interact with morphine and naltrexone.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take morphine and naltrexone with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Morphine and Naltrexone?
- Tell all of your health care providers that you take morphine and naltrexone. This includes your doctors, nurses, pharmacists, and dentists.
- Avoid driving and doing other tasks or actions that call for you to be alert until you see how morphine and naltrexone affects you.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
- Do not take morphine and naltrexone with other strong pain drugs or if you are using a pain patch without talking to your doctor first.
- Have your blood work checked if you are on morphine and naltrexone for a long time. Talk with your doctor.
- This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take morphine and naltrexone.
- This medicine may raise the chance of seizures in some people, including people who have had seizures in the past. Talk to your doctor to see if you have a greater chance of seizures while taking morphine and naltrexone.
- If you are 65 or older, use morphine and naltrexone with care. You could have more side effects.
- If you have been taking morphine and naltrexone for a long time or at high doses, it may not work as well and you may need higher doses to get the same effect. This is known as tolerance. Call your doctor if morphine and naltrexone stops working well. Do not take more than ordered.
- Do not stop taking morphine and naltrexone all of a sudden without calling your doctor. You may have a greater risk of signs of withdrawal. If you need to stop morphine and naltrexone, you will want to slowly stop it as ordered by your doctor.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking morphine and naltrexone, call your doctor right away.
How is this medicine (Morphine and Naltrexone) best taken?
Use morphine and naltrexone as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take with or without food.
- Swallow capsule whole. Do not chew, break, or crush.
- You may sprinkle contents of capsule on applesauce. Do not chew.
- Swallow the mixture right away. Do not store for use at a later time.
- Rinse mouth to make sure all contents have been swallowed.
- Throw away any unused part of the capsule after putting on applesauce.
- Do not inject or snort morphine and naltrexone. Doing any of these things can cause very bad side effects like trouble breathing and death from overdose.
- Do not put morphine and naltrexone down a feeding tube.
- Do not use for fast pain relief or on an as needed basis.
- Do not use for pain relief after surgery if you have not been taking drugs like morphine and naltrexone.
What do I do if I miss a dose?
- Skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
- If you are not sure what to do if you miss a dose, call your doctor.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Very bad dizziness or passing out.
- Very upset stomach or throwing up.
- Very hard stools (constipation).
- Chest pain or pressure or a fast heartbeat.
- Feeling very sleepy.
- Noisy breathing.
- Feeling confused.
- Very bad belly pain.
- Long-term use of an opioid drug like morphine and naltrexone may lead to lower sex hormone levels. This may lead to signs like change in sex ability in men, no menstrual period in women, lowered interest in sex, or fertility problems. Call your doctor if you have any of these signs.
- A very bad and sometimes deadly health problem called serotonin syndrome may happen if you take morphine and naltrexone with drugs for depression, migraines, or certain other drugs. Call your doctor right away if you have agitation; change in balance; confusion; hallucinations; fever; fast or abnormal heartbeat; flushing; muscle twitching or stiffness; seizures; shivering or shaking; sweating a lot; very bad diarrhea, upset stomach, or throwing up; or very bad headache.
- Taking an opioid drug like morphine and naltrexone may lead to a rare but very bad adrenal gland problem. Call your doctor right away if you have very bad dizziness or passing out, very bad upset stomach or throwing up, or if you feel less hungry, very tired, or very weak.
What are some other side effects of Morphine and Naltrexone?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if you have any side effects that bother you or do not go away.
- Feeling sleepy.
- Upset stomach or throwing up.
- Hard stools (constipation).
- Dry mouth.
- Feeling tired or weak.
- Belly pain.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Morphine and Naltrexone?
- Store at room temperature.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time morphine and naltrexone is refilled. If you have any questions about morphine and naltrexone, please talk with the doctor, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about morphine/naltrexone
- Morphine/naltrexone Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- 49 Reviews
- Drug class: narcotic analgesic combinations
Other brands: Embeda