Generic Name: Mitoxantrone (mye toe ZAN trone)
Medically reviewed by Drugs.com. Last updated on Jun 24, 2020.
- This medicine may cause severe heart problems like heart failure. This can happen during treatment or years after your last dose. Sometimes, these problems will not go away or may be deadly. The chance may be higher if you have ever had heart problems or chest area radiation, or are using other drugs that may cause heart problems. The chance may be higher if you have ever had mitoxantrone or other drugs like this one. Ask your doctor if you are not sure if any of your drugs may cause heart problems. The chance of heart problems depends on the dose of this drug and your health problem. In children, the chance of heart problems later in life is higher. Heart problems may happen even without any risk factors. Call your doctor right away if you have cough, fast or slow heartbeat, abnormal heartbeat, swelling in the arms or legs, shortness of breath, sudden weight gain, or feel very tired or weak.
- You will need to have heart function tests while taking mitoxantrone. Talk with the doctor.
- If you have heart disease, talk with your doctor.
- This medicine may lower the ability of your bone marrow to make blood cells that your body needs. This can lead to needing a blood transfusion and very bad and sometimes deadly bleeding problems or infections. Tell your doctor right away if you have signs of infection like fever, chills, or sore throat; any bruising or bleeding; or if you feel very tired or weak.
- This medicine must not be given to some people with low white blood cell counts. Talk with the doctor.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- This medicine may add to the chance of getting some types of cancer. Talk with the doctor.
- This medicine may cause tissue damage if the drug leaks from the vein. Tell your nurse if you have any redness, burning, pain, swelling, blisters, skin sores, or leaking of fluid where the drug is going into your body.
- This medicine must not be given into the spine.
Uses of Mitoxantrone:
- It is used to treat prostate cancer.
- It is used to treat a type of leukemia.
- It is used to treat MS (multiple sclerosis).
- It may be given to you for other reasons. Talk with the doctor.
What do I need to tell my doctor BEFORE I take Mitoxantrone?
- If you have an allergy to mitoxantrone or any other part of mitoxantrone.
- If you are allergic to mitoxantrone; any part of mitoxantrone; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you have liver disease or raised liver enzymes.
- If you are breast-feeding. Do not breast-feed while you take mitoxantrone.
This is not a list of all drugs or health problems that interact with mitoxantrone.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take mitoxantrone with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Mitoxantrone?
For all uses of mitoxantrone:
- Tell all of your health care providers that you take mitoxantrone. This includes your doctors, nurses, pharmacists, and dentists.
- You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
- You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
- If you have upset stomach, throwing up, diarrhea, or are not hungry, talk with your doctor. There may be ways to lower these side effects.
- If you have had daunorubicin, doxorubicin, epirubicin, idarubicin, or mitoxantrone before, talk with your doctor.
- Talk with your doctor before getting any vaccines. Use of some vaccines with mitoxantrone may either raise the chance of an infection or make the vaccine not work as well.
- If you are allergic to sulfites, talk with your doctor. Some products have sulfites.
- If you are 65 or older, use mitoxantrone with care. You could have more side effects.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant.
- You may need to have a pregnancy test while taking mitoxantrone. Talk with your doctor.
- Use birth control that you can trust to prevent pregnancy while taking mitoxantrone.
- If you are pregnant or you get pregnant while taking mitoxantrone, call your doctor right away.
For patients taking mitoxantrone to treat MS (multiple sclerosis):
- This medicine is not a cure for MS (multiple sclerosis). Stay under the care of your doctor.
How is this medicine (Mitoxantrone) best taken?
Use mitoxantrone as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as an infusion into a vein over a period of time.
What do I do if I miss a dose?
- Call your doctor to find out what to do.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of a urinary tract infection (UTI) like blood in the urine, burning or pain when passing urine, feeling the need to pass urine often or right away, fever, lower stomach pain, or pelvic pain.
- Signs of bleeding like throwing up or coughing up blood; vomit that looks like coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a cause or that get bigger; or bleeding you cannot stop.
- Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
- Yellow skin or eyes.
- A big weight loss.
- Feeling very tired or weak.
- Bone pain.
- Night sweats.
- Change in color of skin to a bluish color like on the lips, nail beds, fingers, or toes.
What are some other side effects of Mitoxantrone?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Change in color of body fluids (urine) to blue or green for about 24 hours after getting mitoxantrone. This is normal and not a cause for concern.
- Blue coloring of the whites of the eyes for about 24 hours after getting mitoxantrone. This is normal and not a cause for concern.
- Upset stomach or throwing up.
- Belly pain.
- Not hungry.
- Mouth irritation or mouth sores.
- Hair loss.
- Feeling tired or weak.
- Back pain.
- Signs of a common cold.
- For women, no period.
- Weight loss.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Mitoxantrone?
- If you need to store mitoxantrone at home, talk with your doctor, nurse, or pharmacist about how to store it.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time mitoxantrone is refilled. If you have any questions about mitoxantrone, please talk with the doctor, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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- Drug class: antibiotics/antineoplastics
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Other brands: Novantrone