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Lesinurad

Generic Name: Lesinurad (le SIN ure ad)
Brand Name: Zurampic

Medically reviewed: April 4, 2018

Warning

  • Kidney problems like kidney failure have happened with lesinurad. This was more common in people who took lesinurad without certain other drugs. This medicine must be taken along with either allopurinol or febuxostat. Talk with your doctor.

Uses of Lesinurad:

  • It is used to lower uric acid in the blood.

What do I need to tell my doctor BEFORE I take Lesinurad?

  • If you have an allergy to lesinurad or any part of lesinurad.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have kidney disease or are on dialysis.
  • If you have had a kidney transplant.
  • If you have any of these health problems: Lesch-Nyhan syndrome or tumor lysis syndrome (TLS).
  • If you are taking any of these drugs: Divalproex or valproic acid.

This is not a list of all drugs or health problems that interact with lesinurad.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take lesinurad with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Lesinurad?

  • Tell all of your health care providers that you take lesinurad. This includes your doctors, nurses, pharmacists, and dentists.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • You may have more gout attacks after you first start taking lesinurad. Do not stop taking lesinurad. You may be given other drugs to keep you from having these gout attacks. Talk with your doctor.
  • Very bad heart problems like heart attack and stroke have happened with lesinurad. Sometimes, these heart problems were deadly. It is not known if lesinurad is what caused these effects. Talk with the doctor.
  • Birth control pills and other hormone-based birth control may not work as well to prevent pregnancy. Use some other kind of birth control also like a condom when taking lesinurad.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using lesinurad while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Lesinurad) best taken?

Use lesinurad as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take in the morning.
  • Take with food.
  • Take with a full glass of water.
  • Take lesinurad at the same time as the drug you take it with. Do not take lesinurad by itself. Tell your doctor if you stop taking the other drug for any reason.
  • Drink lots of noncaffeine liquids every day unless told to drink less liquid by your doctor.

What do I do if I miss a dose?

  • Skip the missed dose and go back to your normal time.
  • Do not take more than 1 dose of lesinurad in the same day.

See also: Dosage Information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
  • Upset stomach or throwing up.
  • Lower back or side pain.

What are some other side effects of Lesinurad?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

See also: Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Lesinurad?

  • Store at room temperature.
  • Protect from light.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about lesinurad, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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