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Generic Name: Epoprostenol (e poe PROST en ole)
Brand Name: Flolan, Veletri

Medically reviewed by Last updated on Aug 22, 2020.

Uses of Epoprostenol:

What do I need to tell my doctor BEFORE I take Epoprostenol?

  • If you have an allergy to epoprostenol or any other part of epoprostenol.
  • If you are allergic to epoprostenol; any part of epoprostenol; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you have heart failure (weak heart).
  • If you have ever gotten fluid in the lungs with use of epoprostenol.

This is not a list of all drugs or health problems that interact with epoprostenol.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take epoprostenol with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Epoprostenol?

  • Tell all of your health care providers that you take epoprostenol. This includes your doctors, nurses, pharmacists, and dentists.
  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how epoprostenol affects you.
  • You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
  • Check your blood pressure as you have been told.
  • Do not stop taking epoprostenol all of a sudden without calling your doctor. Signs of high pressure in the lungs like shortness of breath, dizziness, or weakness may get worse. Talk with your doctor.
  • Always have a backup system close by in case you need to use it.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using epoprostenol while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Epoprostenol) best taken?

Use epoprostenol as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given into the vein nonstop.
  • It is likely that treatment will be needed for a long time, maybe years. You will need to closely follow how to use epoprostenol and how to care for the catheter and infusion pump. Talk with the doctor if you have questions.
  • Your doctor may teach you how to give epoprostenol.
  • Wash your hands before and after use.
  • Do not use if the solution is cloudy, leaking, or has particles.
  • Do not use if solution changes color.
  • Be sure you know what types of materials and tubing to use with epoprostenol. If you are not sure, talk with the doctor or pharmacist.

What do I do if I miss a dose?

  • It is important that the infusion does not stop unless your doctor tells you otherwise. If you miss a dose or if the infusion stops, get medical help right away.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of bleeding like throwing up or coughing up blood; vomit that looks like coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a cause or that get bigger; or bleeding you cannot stop.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Shortness of breath.
  • Very bad dizziness or passing out.
  • Very bad headache.
  • Dark urine.
  • Chest pain or pressure or a fast heartbeat.
  • Slow heartbeat.
  • A heartbeat that does not feel normal.
  • Pale skin.
  • Shakiness.
  • Trouble controlling body movements.
  • Feeling very tired or weak.
  • A burning, numbness, or tingling feeling that is not normal.
  • Swelling of belly.
  • Redness or swelling where the shot is given.
  • Skin sores.
  • Very bad irritation where the shot was given.

What are some other side effects of Epoprostenol?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Anxiety.
  • Back pain.
  • Irritation where the shot is given.
  • Headache.
  • Diarrhea.
  • Dizziness.
  • Flushing.
  • Not hungry.
  • Jaw pain.
  • Bone, joint, or muscle pain.
  • Upset stomach or throwing up.
  • Flu-like signs. These include headache, weakness, fever, shakes, aches, pains, and sweating.
  • Feeling nervous and excitable.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Epoprostenol?

  • Store as you have been told by the doctor.
  • After opening or mixing epoprostenol with fluids, be sure you know how to store epoprostenol and how long the drug is good for.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about epoprostenol, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.