Generic Name: carfilzomib (kar-FILZ-oh-mib)
Brand Name: Kyprolis
Carfilzomib is used for:
Treating multiple myeloma in certain patients. It may also be used for other conditions as determined by your doctor.
Carfilzomib is an antineoplastic (cancer chemotherapy) medicine. It works by blocking certain proteins within the cancer cell, causing the cell to die. This helps to slow the growth and spread of the cancer.
Do NOT use carfilzomib if:
- you are allergic to any ingredient in carfilzomib
Contact your doctor or health care provider right away if any of these apply to you.
Before using carfilzomib:
Some medical conditions may interact with carfilzomib. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of diabetes or high blood sugar levels; heart problems (eg, heart failure); heart attack; high or low blood pressure; high blood calcium levels; kidney problems; liver problems or abnormal liver function tests; low blood magnesium, phosphate, potassium, or sodium levels; low white blood cell counts; low blood platelets; lung problems (eg, pulmonary arterial hypertension [PAH]); peripheral neuropathy (burning, numbness, or tingling in the arms, hands, legs, or feet); or herpes infection (eg, genital herpes, shingles, cold sores)
- if you are dehydrated or you are on dialysis
Some MEDICINES MAY INTERACT with carfilzomib. However, no specific interactions with carfilzomib are known at this time.
Ask your health care provider if carfilzomib may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use carfilzomib:
Use carfilzomib as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Carfilzomib is given as an injection at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.
- Drinking extra fluids while you are taking carfilzomib is recommended. Check with your doctor for instructions.
- Your doctor may prescribe a corticosteroid medicine (eg, dexamethasone) for you to take before you use carfilzomib. This will help to decrease the risk of an infusion reaction. Discuss any questions or concerns with your doctor.
- It is very important that each dose is given at the scheduled time. If you miss a dose of carfilzomib, contact your doctor right away to establish a new dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use carfilzomib.
Important safety information:
- Tell your doctor or dentist that you take carfilzomib before you receive any medical or dental care, emergency care, or surgery.
- Carfilzomib may cause dizziness, fatigue, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use carfilzomib with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Infusion reactions have occurred in patients immediately after receiving carfilzomib or within 24 hours of receiving it. Tell your doctor right away if you experience chest pain or tightness; chills; fainting; fever; flushing or redness; joint or muscle pain or aches; severe or persistent dizziness or light-headedness; shortness of breath; swelling of the face; unusual weakness; or vomiting.
- Carfilzomib may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
- Carfilzomib may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
- A serious and possibly fatal condition called tumor lysis syndrome (TLS) has been reported in patients taking carfilzomib. Contact your doctor right away if you develop symptoms, such as fast or irregular heartbeat; fainting; decreased urination; muscle weakness or cramps; nausea, vomiting, diarrhea, or loss of appetite; or sluggishness. Discuss any questions or concerns with your doctor.
- Heart failure has happened with this drug, as well as heart failure that has gotten worse in people who already have it. Tell your doctor if you have heart disease. Call your doctor right away if you have shortness of breath, a big weight gain, a heartbeat that is not normal, or swelling in the arms or legs that is new or worse.
- A serious and sometimes fatal blood problem called thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) has happened with carfilzomib. Call your doctor right away if you have any bruising or bleeding; unusual tiredness or weakness; dark urine or yellow skin or eyes; pale skin; change in how much urine is passed; vision changes; one-sided weakness, trouble speaking or thinking, or change in balance; or fever.
- A serious and sometimes fatal brain problem called posterior reversible encephalopathy syndrome (PRES) has happened with carfilzomib. Call your doctor right away if you have signs like confusion, decreased alertness, vision changes (eg, loss of eyesight), seizures, or severe headache, Discuss any questions or concerns with your doctor.
- Serious and sometimes fatal liver and lung problems have happened with carfilzomib. Discuss any questions or concerns with your doctor.
- If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions. Contact your doctor right away if you experience dizziness, light-headedness, or fainting.
- Carfilzomib may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
- Diabetes patients - Carfilzomib may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
- Women of childbearing age should avoid becoming pregnant while being treated with carfilzomib. Be sure to use effective birth control while using carfilzomib.
- Lab tests may be performed while you use carfilzomib. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- PREGNANCY and BREAST-FEEDING: Carfilzomib may cause harm to the fetus. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if this medicine is found in breast milk. Do not breast-feed while using carfilzomib.
Possible side effects of carfilzomib:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Back or joint pain; constipation; diarrhea; dizziness; headache; loss of appetite; nausea; tiredness; trouble sleeping; vomiting; weakness.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); burning, numbness, or tingling in the arms, hands, legs, or feet; chest pain; confusion; decreased sense of touch; decreased urination; fainting; fast or irregular heartbeat; mental or mood changes; muscle aches, cramps, pain, spasms, or weakness; seizures; severe or persistent headache, dizziness, or light-headedness; severe or persistent nausea, diarrhea, or vomiting; shortness of breath; sluggishness; sudden, unexplained weight gain; swelling or pain in the hands, ankles, feet, or legs; symptoms of bleeding (eg, vomiting blood or vomit that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; unusual vaginal bleeding; bruises without a reason or that get bigger; any bleeding that is severe or that you cannot stop); symptoms of infection (eg, fever, chills, sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, painful urination, mouth sores, wound that will not heal, anal itching or pain); symptoms of liver problems (eg, dark urine, persistent loss of appetite, pale stools, unusual nausea or stomach pain, yellowing of the skin or eyes); symptoms of lung or breathing problems (eg, shortness of breath or other trouble breathing, cough, fever); tremor; unusual tiredness or weakness.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of carfilzomib:
Carfilzomib is handled and stored by a health care provider. You will not store it at home. Keep all medicines out of the reach of children and away from pets.
- If you have any questions about carfilzomib, please talk with your doctor, pharmacist, or other health care provider.
- Carfilzomib is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take carfilzomib or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about carfilzomib. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to carfilzomib. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using carfilzomib.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about carfilzomib
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
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- Drug class: proteasome inhibitors
Other brands: Kyprolis