Generic Name: Carfilzomib (kar FILZ oh mib)
Brand Name: Kyprolis
Medically reviewed: April 4, 2018
Uses of Carfilzomib:
- It is used to treat multiple myeloma.
- It may be given to you for other reasons. Talk with the doctor.
- If you have just been diagnosed with multiple myeloma and cannot have a transplant, talk with your doctor. A study showed that these patients taking carfilzomib with certain other drugs (melphalan and prednisone) had more very bad and sometimes deadly side effects compared to a certain other drug.
What do I need to tell my doctor BEFORE I take Carfilzomib?
- If you have an allergy to carfilzomib or any other part of carfilzomib.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have high blood pressure.
- If you are pregnant or may be pregnant. Do not take carfilzomib if you are pregnant. This medicine may cause harm to the unborn baby if you take it while you are pregnant. Use birth control that you can trust to prevent pregnancy while taking carfilzomib and for at least 30 days after your last dose. If you get pregnant while taking carfilzomib or within 30 days after your last dose, call your doctor right away.
- If you are a man and have sex with a female who could get pregnant. Do not father a child while taking carfilzomib. Protect your sex partner from pregnancy while taking carfilzomib and for at least 90 days after your last dose. If your sex partner gets pregnant while you take carfilzomib or within 90 days after your last dose, call your doctor right away.
- If you are breast-feeding or plan to breast-feed.
This is not a list of all drugs or health problems that interact with carfilzomib.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take carfilzomib with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Carfilzomib?
- Tell all of your health care providers that you take carfilzomib. This includes your doctors, nurses, pharmacists, and dentists.
- Avoid driving and doing other tasks or actions that call for you to be alert until you see how carfilzomib affects you.
- Very bad and sometimes deadly bleeding problems have happened with carfilzomib. Talk with the doctor.
- Death caused by heart attack has happened within a day of getting carfilzomib. Talk with your doctor.
- A very bad and sometimes deadly brain problem called posterior reversible encephalopathy syndrome (PRES) has happened with carfilzomib. Call your doctor right away if you have signs like feeling confused, lowered alertness, change in eyesight, loss of eyesight, seizures, or very bad headache.
- Very bad and sometimes deadly blood problems like thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) have happened with carfilzomib in some people. Call your doctor right away if you feel very tired or weak or have any bruising or bleeding; dark urine or yellow skin or eyes; pale skin; change in the amount of urine passed; change in eyesight; change in strength on 1 side is greater than the other, trouble speaking or thinking, or change in balance; or fever.
- Patients with cancer who take carfilzomib may be at a greater risk of getting a bad health problem called tumor lysis syndrome (TLS). Sometimes, this has been deadly. Call your doctor right away if you have a fast heartbeat or a heartbeat that does not feel normal; any passing out; trouble passing urine; muscle weakness or cramps; upset stomach, throwing up, loose stools, or not able to eat; or feel sluggish.
- Heart failure has happened with carfilzomib, as well as heart failure that has gotten worse in people who already have it. Tell your doctor if you have heart disease. Call your doctor right away if you have shortness of breath, a big weight gain, a heartbeat that is not normal, or swelling in the arms or legs that is new or worse.
- Infusion reactions have happened with carfilzomib. Sometimes, these could be very bad or life-threatening. Talk with the doctor.
- High blood pressure has happened with carfilzomib. Sometimes, this has been deadly. Have your blood pressure checked as you have been told by your doctor.
- Kidney problems have happened with carfilzomib. Sometimes, these have been deadly. Talk with the doctor.
- Call your doctor right away if you have signs of a blood clot like chest pain or pressure; coughing up blood; shortness of breath; swelling, warmth, numbness, change of color, or pain in a leg or arm; or trouble speaking or swallowing.
- Tell your doctor if you have signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
- If you are 65 or older, use carfilzomib with care. You could have more side effects.
How is this medicine (Carfilzomib) best taken?
Use carfilzomib as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as an infusion into a vein over a period of time.
- You will need to be sure that you are not dehydrated before getting carfilzomib. Check with your doctor to see if you need to drink extra fluids before getting carfilzomib.
- Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.
- If you have upset stomach, throwing up, loose stools (diarrhea), or are not hungry, talk with your doctor. There may be ways to lower these side effects.
- Other drugs may be given to help with infusion side effects.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
- You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
What do I do if I miss a dose?
- Call your doctor to find out what to do.
See also: Dosage Information (in more detail)
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
- Signs of electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, seizures, not hungry, or very bad upset stomach or throwing up.
- Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
- Chest pain or pressure.
- Dizziness or passing out.
- Very bad headache.
- A burning, numbness, or tingling feeling that is not normal.
- Feeling very tired or weak.
- Muscle or joint pain.
- Very bad and sometimes deadly lung problems have happened with carfilzomib. Call your doctor right away if you have lung or breathing problems like trouble breathing, shortness of breath, or a cough that is new or worse.
- Very bad and sometimes deadly liver problems have happened with carfilzomib. Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
What are some other side effects of Carfilzomib?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Hard stools (constipation).
- Loose stools (diarrhea).
- Not hungry.
- Feeling tired or weak.
- Back pain.
- Not able to sleep.
- Upset stomach or throwing up.
- Nose or throat irritation.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
See also: Side effects (in more detail)
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Carfilzomib?
- If you need to store carfilzomib at home, talk with your doctor, nurse, or pharmacist about how to store it.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about carfilzomib, please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about carfilzomib
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- En Español
- 2 Reviews – Add your own review/rating
- Drug class: proteasome inhibitors
Other brands: Kyprolis