Generic Name: Axicabtagene Ciloleucel (ax i CAB tay jeen sye LO loo sel)
Brand Name: Yescarta
Medically reviewed by Drugs.com. Last updated on Oct 30, 2020.
- A very bad health problem called cytokine release syndrome (CRS) has happened with axicabtagene ciloleucel. Sometimes, this has been life-threatening or deadly. This can happen while getting axicabtagene ciloleucel or within 4 weeks after getting axicabtagene ciloleucel. Get medical help right away if you have signs like chills; confusion; dizziness; feeling tired or weak; fever; headache; passing out; rash; swelling of the face; trouble breathing; very bad muscle or joint pain; very bad upset stomach, throwing up, or diarrhea; or wheezing.
- Do not take axicabtagene ciloleucel if you have an infection or any inflammation.
- Nervous system problems have happened after treatment with axicabtagene ciloleucel. Sometimes, these have been very bad or life-threatening. Call your doctor right away if you feel agitated, confused, nervous, or restless. Call your doctor right away if you have anxiety, change in eyesight, dizziness or passing out, hallucinations (seeing or hearing things that are not there), headaches, seizures, shakiness, trouble speaking, or new or worse behavior or mood changes.
Uses of Axicabtagene Ciloleucel:
- It is used to treat a type of lymphoma.
What do I need to tell my doctor BEFORE I take Axicabtagene Ciloleucel?
- If you are allergic to axicabtagene ciloleucel; any part of axicabtagene ciloleucel; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
This medicine may interact with other drugs or health problems.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take axicabtagene ciloleucel with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Axicabtagene Ciloleucel?
- Tell all of your health care providers that you take axicabtagene ciloleucel. This includes your doctors, nurses, pharmacists, and dentists.
- Avoid driving and doing other tasks or actions that call for you to be alert for at least 8 weeks after getting axicabtagene ciloleucel. If you have any questions, call your doctor or pharmacist.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- You may have more of a chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu. Some infections have been very bad and even deadly.
- Call your doctor right away if you have any signs of infection like fever, chills, flu-like signs, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or a wound that will not heal.
- You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
- If you have had hepatitis B before or carry the virus, talk with your doctor. Drugs like this one can cause the virus to become active. This can lead to very bad and sometimes deadly liver problems.
- Hepatitis and HIV testing will be done before taking axicabtagene ciloleucel.
- Talk with your doctor before getting any vaccines. Some types of vaccines must not be given for at least 6 weeks before starting axicabtagene ciloleucel, during treatment, and for some time after your last dose.
- This medicine may add to the chance of getting some types of cancer. Talk with the doctor.
- Do not donate blood, organs, or tissues or cells. Talk with your doctor to see when you can do these things after getting axicabtagene ciloleucel.
- This medicine may cause harm to an unborn baby. A pregnancy test will be done before you start axicabtagene ciloleucel to show that you are NOT pregnant.
- Women must use birth control while taking axicabtagene ciloleucel and for some time after the last dose. Ask your doctor how long to use birth control. If you get pregnant, call your doctor right away.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
How is this medicine (Axicabtagene Ciloleucel) best taken?
Use axicabtagene ciloleucel as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as an infusion into a vein over a period of time.
- Other drugs may be given before axicabtagene ciloleucel to help avoid side effects.
What do I do if I miss a dose?
- Call your doctor to find out what to do.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of bleeding like throwing up or coughing up blood; vomit that looks like coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a cause or that get bigger; or bleeding you cannot stop.
- Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
- Signs of high or low blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
- Signs of fluid and electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, very bad dizziness or passing out, fast heartbeat, more thirst, seizures, feeling very tired or weak, not hungry, unable to pass urine or change in the amount of urine produced, dry mouth, dry eyes, or very bad upset stomach or throwing up.
- Shortness of breath, a big weight gain, or swelling in the arms or legs.
- Feeling very tired or weak.
- Fast or abnormal heartbeat.
- Trouble sleeping.
- Feeling very sleepy.
- Not able to focus.
- Swelling, warmth, numbness, change of color, or pain in a leg or arm.
- Chest pain or pressure.
What are some other side effects of Axicabtagene Ciloleucel?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Constipation, diarrhea, stomach pain, upset stomach, throwing up, or feeling less hungry.
- Dry mouth.
- Weight loss.
- Feeling dizzy, tired, or weak.
- Pain in arms or legs.
- Back, muscle, or joint pain.
- Muscle spasm.
- Muscle weakness.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Axicabtagene Ciloleucel?
- If you need to store axicabtagene ciloleucel at home, talk with your doctor, nurse, or pharmacist about how to store it.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about axicabtagene ciloleucel, please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Frequently Asked Questions
- What is the cost of Yescarta?
- How is Yescarta administered?
- What type of drug is Yescarta (axicabtagene ciloleucel)?
More about axicabtagene ciloleucel
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- Drug class: miscellaneous antineoplastics
Other brands: Yescarta