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Arranon

Generic Name: nelarabine (nel-AR-a-been)
Brand Name: Arranon

Severe nervous system problems have been reported with the use if Arranon. These problems have included mental or mood changes; severe drowsiness; seizures; numbness, burning, prickling, or tingling of the skin, hands, or feet; weakness; and paralysis. Contact your doctor right away if you experience any of these symptoms.

These symptoms may not go away even after you stop using Arranon. Discuss any questions or concerns with your doctor.


Arranon is used for:

Treating leukemia or lymphoma in certain patients. It may also be used for other conditions as determined by your doctor.

Arranon is an antineoplastic agent. It works by blocking the growth of cancer cells.

Do NOT use Arranon if:

  • you are allergic to any ingredient in Arranon
  • you are using an adenosine deaminase inhibitor (eg, pentostatin)
  • you have taken or will be taking palifermin within 24 hours before or after using Arranon

Contact your doctor or health care provider right away if any of these apply to you.

Before using Arranon:

Some medical conditions may interact with Arranon. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are able to become pregnant
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have bone marrow problems, nervous system problems, kidney problems, or liver problems
  • if you have a history of gout or high uric acid levels
  • if you are receiving or have ever received chemotherapy or radiation treatment
  • if you have recently had a vaccination

Some MEDICINES MAY INTERACT with Arranon. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Palifermin because if mouth or tongue sores develop, they may be more severe or last longer
  • Adenosine deaminase inhibitors (eg, pentostatin) because they may decrease Arranon's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Arranon may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Arranon:

Use Arranon as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Arranon. Talk to your pharmacist if you have questions about this information.
  • Arranon is usually given as an injection at your doctor's office, hospital, or clinic.
  • If you miss a dose of Arranon, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Arranon.

Important safety information:

  • Arranon may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Arranon with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.
  • Arranon may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • Arranon may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Do not receive a live vaccine (eg, measles, mumps) while you are taking Arranon. Talk with your doctor before you receive any vaccine.
  • Diabetes patients - Arranon may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Discuss with your doctor the use of effective contraception (birth control) while you are using Arranon.
  • Lab tests, including complete blood cell counts, may be performed while you use Arranon. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Arranon with caution in the ELDERLY; they may be more sensitive to its effects, especially nervous system problems.
  • PREGNANCY and BREAST-FEEDING: Arranon may cause harm to the fetus. Do not become pregnant while you are using it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Arranon while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking Arranon.

Possible side effects of Arranon:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; constipation; cough; diarrhea; dizziness; drowsiness; headache; loss of appetite; muscle, joint, or back pain; nausea; stomach pain; stuffy nose; tiredness; trouble sleeping; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; coma; confusion; decreased sense of touch; depression; fainting; fast heartbeat; fever, chills, or sore throat; loss of coordination; memory loss; mental or mood changes; mouth or tongue sores, swelling, or soreness; new or worsening numbness, burning, prickling, or tingling of the skin, hands, or feet; nosebleed; paralysis; seizures; severe dizziness or drowsiness; severe or unusual muscle pain, tenderness, cramping, or weakness; shortness of breath; stomach swelling; swelling of the hands, feet, or legs; symptoms of dehydration (eg, dry mouth or eyes, sluggishness); tremor; trouble with fine motor skills (eg, buttoning clothing); unsteadiness while walking; unusual bruising or bleeding; unusual tiredness; unusually pale skin; weakness; wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include coma; paralysis; unusual bruising or bleeding; unusual tiredness or weakness.

Proper storage of Arranon:

Arranon is handled and stored by a health care provider. Keep Arranon out of the reach of children and away from pets.

General information:

  • If you have any questions about Arranon, please talk with your doctor, pharmacist, or other health care provider.
  • Arranon is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Arranon or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Arranon. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Arranon. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Arranon.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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