Generic Name: amlodipine and benazepril (am-LOE-di-peen & ben-AZ-e-pril)
Brand Name: Lotrel
Amlodipine/benazepril may cause birth defects or fetal or newborn death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. If you are planning to become pregnant, talk with your doctor about other treatment options.
Amlodipine/ benazepril is used for:
Treating high blood pressure in certain patients. It may be used alone or with other medicines.
Amlodipine/benazepril is an angiotensin-converting enzyme (ACE) inhibitor and a calcium channel blocker combination. It works by helping your blood vessels relax, which lowers blood pressure.
Do NOT use amlodipine/ benazepril if:
- you are allergic to any ingredient in amlodipine/benazepril or any ACE inhibitor (eg, lisinopril)
- you have a history of angioedema (eg, swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; unusual hoarseness)
- you have severe kidney problems
- you are pregnant
- you are taking a medicine that contains aliskiren and you also have diabetes or kidney problems. Check with your doctor or pharmacist if you are not sure if a medicine you take contains aliskiren
Contact your doctor or health care provider right away if any of these apply to you.
Before using amlodipine/ benazepril:
Some medical conditions may interact with amlodipine/benazepril. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are able to become pregnant
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement, especially extra potassium or a salt substitute
- if you have allergies to medicines, foods, or other substances
- if you have a history of heart attack or other heart problems (eg, heart failure, aortic stenosis, angina, coronary artery disease), blood vessel problems (eg, in the brain), blood flow problems, kidney problems (eg, renal artery stenosis), liver problems, diabetes, or a kidney transplant
- if you have an autoimmune disease (eg, rheumatoid arthritis, lupus, scleroderma), bone marrow problems (eg, bone marrow suppression), or low white blood cell levels
- if you are dehydrated, have low blood volume, or low blood pressure
- if you have high blood potassium levels, low blood sodium levels, or are on a low-salt (sodium) diet
- if you are receiving treatments to reduce sensitivity to bee or wasp stings
- if you are receiving kidney dialysis or apheresis, or you are scheduled to have surgery or receive anesthesia
- if you drink alcohol
- if you take other medicines for high blood pressure or heart failure
Some MEDICINES MAY INTERACT with amlodipine/benazepril. Tell your health care provider if you are taking other medicines, especially any of the following:
- Eplerenone, potassium-sparing diuretics (eg, spironolactone, triamterene), potassium supplements, or trimethoprim because the risk of high blood potassium levels may be increased
- Aliskiren or angiotensin receptor blockers (ARBs) (eg, losartan) because the risk of certain side effects (eg, kidney problems, high blood potassium levels, low blood pressure) may be increased
- Everolimus, sirolimus, temsirolimus because the risk of angioedema may be increased
- Insulin or oral diabetes medicine (eg, glyburide) because the risk of low blood sugar levels may be increased
- Certain gold-containing medicines (eg, sodium aurothiomalate) because flushing, nausea, vomiting, and low blood pressure may occur
- Azole antifungals (eg, itraconazole, ketoconazole), cobicistat, conivaptan, cyclosporine, dextran sulfate, diuretics (eg, furosemide, hydrochlorothiazide), macrolide antibiotics (eg, clarithromycin), probenecid, or protease inhibitors (eg, ritonavir, telaprevir) because they may increase the risk of amlodipine/benazepril's side effects
- Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin, celecoxib) because they may decrease amlodipine/benazepril's effectiveness, and the risk of kidney problems and high blood potassium levels may be increased
- Lithium, simvastatin, or tacrolimus because the risk of their side effects may be increased by amlodipine/benazepril
This may not be a complete list of all interactions that may occur. Ask your health care provider if amlodipine/benazepril may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use amlodipine/ benazepril:
Use amlodipine/benazepril as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with amlodipine/benazepril. Talk to your pharmacist if you have questions about this information.
- Take amlodipine/benazepril by mouth with or without food.
- Take amlodipine/benazepril on a regular schedule to get the most benefit from it.
- Taking amlodipine/benazepril at the same time each day will help you remember to take it.
- If you miss a dose of amlodipine/benazepril, take it as soon as possible. If it is within 12 hours of your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use amlodipine/benazepril.
Important safety information:
- Tell your doctor or dentist that you take amlodipine/benazepril before you receive any medical or dental care, emergency care, or surgery.
- Amlodipine/benazepril may cause dizziness, light-headedness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Take amlodipine/benazepril with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Amlodipine/benazepril may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- It may take up to 2 weeks to receive the full benefits from amlodipine/benazepril. Do not change your dose or stop taking amlodipine/benazepril without checking with your doctor.
- If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.
- Check with your doctor before you use a salt substitute or a product that has potassium in it.
- If vomiting, diarrhea, or excessive sweating occurs, you will need to take care not to become dehydrated. This could increase your risk of low blood pressure. Contact your doctor for instructions.
- A persistent, unproductive cough may occur. Tell your doctor if this occurs. Recovery is usually rapid when the medicine is stopped.
- Amlodipine/benazepril may cause a serious side effect called angioedema. The risk may be higher in black patients. Contact your doctor at once if you develop swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness.
- Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
- Amlodipine/benazepril may not work as well in black patients. Contact your doctor if your symptoms do not improve or if they become worse.
- Proper dental care is important while you are taking amlodipine/benazepril. Brush and floss your teeth and visit the dentist regularly.
- Although rare, a component of amlodipine/benazepril (amlodipine) has been known to increase chest pain and increase the risk of a heart attack, especially in patients with severe heart disease.
- Lab tests, including blood potassium levels, blood pressure, and kidney function, may be performed while you take amlodipine/benazepril. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use amlodipine/benazepril with caution in the ELDERLY; they may be more sensitive to its effects.
- PREGNANCY and BREAST-FEEDING: Amlodipine/benazepril may cause birth defects or fetal or newborn death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. Amlodipine/benazepril is found in breast milk. Do not breast-feed while taking amlodipine/benazepril.
Possible side effects of amlodipine/ benazepril:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Dizziness; headache; persistent, dry cough.
Severe allergic reactions (rash; hives; itching; difficulty swallowing or breathing; tightness in the chest; swelling of the mouth, hands, eyes, throat, face, lips, or tongue; unusual hoarseness); blisters or sores in the mouth, nose, throat, or on the genitals; chest, jaw, or arm pain; dark urine; decreased urination; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; flu-like symptoms; loss of appetite; muscle cramps, pain, or weakness; pale stools; red, swollen, blistered, or peeling skin; severe or persistent dizziness or light-headedness; severe or persistent nausea, diarrhea, or vomiting; shortness of breath; stiff muscles, tremors, or muscle movements that are not normal; stomach pain; swelling of the hands, feet, or ankles; tender, bleeding, or swollen gums; unexplained weight gain; unusual bruising or bleeding; unusual sweating; unusual weakness or tiredness; wheezing; worsening of angina pain (eg, longer, more often, more severe); yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of amlodipine/benazepril:
Store amlodipine/benazepril at room temperature between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep amlodipine/benazepril out of the reach of children and away from pets.
- If you have any questions about amlodipine/benazepril, please talk with your doctor, pharmacist, or other health care provider.
- Amlodipine/benazepril is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take amlodipine/benazepril or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about amlodipine/benazepril. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to amlodipine/benazepril. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using amlodipine/benazepril.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about amlodipine/benazepril
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- Drug class: ACE inhibitors with calcium channel blocking agents
Other brands: Lotrel