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Ado-Trastuzumab Emtansine

Generic Name: Ado-Trastuzumab Emtansine (a do tras TU zoo mab em TAN seen)
Brand Name: Kadcyla

Medically reviewed on Sep 5, 2018

Warning

  • Very bad and sometimes deadly liver problems have happened with ado-trastuzumab emtansine. Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • This medicine may cause heart failure. You will need to have your heart function checked while taking ado-trastuzumab emtansine. Call your doctor right away if you have signs of heart problems like a cough or shortness of breath that is new or worse, swelling of the ankles or legs, a heartbeat that does not feel normal, weight gain of more than 5 pounds in 24 hours, dizziness, or passing out.
  • If you are able to get pregnant, a pregnancy test will be done to show that you are NOT pregnant before starting ado-trastuzumab emtansine. Talk with your doctor.
  • This medicine may cause harm to the unborn baby or loss of the unborn baby if you take it while you are pregnant.
  • Use birth control that you can trust to prevent pregnancy while taking ado-trastuzumab emtansine and for at least 7 months after stopping ado-trastuzumab emtansine.
  • If you get pregnant while taking ado-trastuzumab emtansine or within 7 months after your last dose, call your doctor right away.

Uses of Ado-Trastuzumab Emtansine:

See also: Kisqali

What do I need to tell my doctor BEFORE I take Ado-Trastuzumab Emtansine?

  • If you have an allergy to ado-trastuzumab emtansine or any other part of ado-trastuzumab emtansine.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you are breast-feeding. Do not breast-feed while you take ado-trastuzumab emtansine or within 7 months after you stop taking it.

This medicine may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take ado-trastuzumab emtansine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Ado-Trastuzumab Emtansine?

  • Tell all of your health care providers that you take ado-trastuzumab emtansine. This includes your doctors, nurses, pharmacists, and dentists.
  • You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
  • You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
  • Very bad and sometimes deadly bleeding problems have happened with ado-trastuzumab emtansine. Talk with the doctor.
  • Some people have side effects during the infusion. These include chills, fast heartbeat, fever, flushing, shortness of breath, very bad dizziness or passing out, and wheezing. You will be watched closely during the infusion and for some time after. Tell your doctor if you have any of these side effects or any other effects during the infusion.
  • This medicine may affect fertility. Fertility problems may lead to not being able to get pregnant or father a child. Talk with the doctor.
  • If you are a man and have sex with a female who could get pregnant, protect her from pregnancy during care and for at least 4 months after stopping ado-trastuzumab emtansine. Use birth control that you can trust.
  • If you are a man and your sex partner gets pregnant while you take ado-trastuzumab emtansine or within 4 months after your last dose, call your doctor right away.

How is this medicine (Ado-Trastuzumab Emtansine) best taken?

Use ado-trastuzumab emtansine as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as an infusion into a vein over a period of time.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
  • Signs of low potassium levels like muscle pain or weakness, muscle cramps, or a heartbeat that does not feel normal.
  • A burning, numbness, or tingling feeling that is not normal.
  • Feeling very tired or weak.
  • Swelling in the arms or legs.
  • Very bad and sometimes deadly lung problems have happened with ado-trastuzumab emtansine. Call your doctor right away if you have lung or breathing problems like trouble breathing, shortness of breath, or a cough that is new or worse.
  • This medicine may irritate the vein. If the drug leaks from the vein, it may also cause irritation around that area. Tell your nurse if you have any redness, burning, pain, swelling, or leaking of fluid where the drug is going into your body.

What are some other side effects of Ado-Trastuzumab Emtansine?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Dry mouth.
  • Change in taste.
  • Belly pain.
  • Upset stomach or throwing up.
  • Loose stools (diarrhea).
  • Hard stools (constipation).
  • Feeling tired or weak.
  • Muscle or joint pain.
  • Headache.
  • Nosebleed.
  • Not able to sleep.
  • Rash.
  • Dizziness.
  • Mouth irritation.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Ado-Trastuzumab Emtansine?

  • If you need to store ado-trastuzumab emtansine at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about ado-trastuzumab emtansine, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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