Wondering if those of you who have started Praluent did so because you experienced muscle pain on statins. If so, have you had any muscle pain that may be associated with Praluent?
Have any of you experienced muscle pain since starting Praluent?
Question posted by medq on 24 Feb 2016
Last updated on 8 February 2022 by medq
I can't answer your question about Praluent and muscle pain specifically because I am now taking Repatha in addition to a low doses of Lipitor and Zetia. However, because I have a long history of high cholesterol and years of statin use and have experienced mild to severe muscle pain over the years, I wanted to share what has been helpful to me in the last few years:
1. Plant sterols to lower cholesterol. (I take NatureMade CholestOff but there are other options.)
Phytosterols were recommended to me by a lipid clinic because they have been shown to lower cholesterol by about 10% in addition to statins and PCSK9 benefits.
2. OTC magnesium glycinate
Be sure to check with your health care provider as there isn't agreement about the benefit of supplements but I wanted to share my experience as muscle pain often leads us to discontinue lipid lowering prescription options when they have demonstrated cholesterol lowering benefits.
I have been on repatha for 4 months.
Did wonders for lipids.
However now muscle spasms and leg cramps are horrible
Up all night.
Anyone have similar?
Thinking about changing to praulent.
Any help out there?
After trying all the statin drugs, my husband suffered muscle pain and joint pain so severe he could not get out of bed. His doctor prescribed 75mg of Praluent, injected every 2 weeks. He started complaining of joint pain and muscle pain about 3 months after his first dose. After 8 months he's still taking it because it's dropped his LDL down to 54, HDL is up from 34 to 50. He has 3 stents in his heart so his cardiologist wants his LDL to stay under 70. He cannot sleep at night unless he takes 3 extra strength Tylenol, and that barely helps him cope with the pain he feels. He takes 2 more Tylenol each morning, then moving helps lesson the pain somewhat, but the pain never really goes away, it's always there. Sometimes so severe, he's very sick from it.
Due to the heart stents, he's also taking Brilinta, low dose aspirin, and metoprolol Tartrate. We've wondered if either of these could cause pain, but his cardiologist says it's highly unlikely. I think I'm convinced it's the Praluent, which is unfortunate because it works so well to keep the LDL way low.
I’m on Repatha. I couldn’t take the statins. The day after my first and second injection I had some muscle pain. Now I take 2 Aleve at the same time of my injections and I have no muscle pain at all.
I started taking Praluent 75mg injections Sept. 1, 2018. So far no side effects. I'm on my 14th injection taken every other Friday. I also take 10 mg. Atorvastatin. A year ago my bad Ldl was 200. Today my bad Ldl is 40. A big drop. I'm a 72 year old man in good health. The highest dose statin I can stand is 10mg. Any higher brings on severe muscle pain. I'm waiting for Bempedoic pills to come on the market to lower my Ldl another 20% with no side effects.
Hi, I originally was on repatha. I had MI and multiple white matter scars of my brain. I'm just 64 and was selected as a candidate for this particular group of drugs.
To be honest just after the first injection, I felt strangely full up and had difficulty swallowing, now, not critical but uncomfortable . I had tightness in my chest very similar to my MI. Anyway this drug had very serious side effects.
My Dr then decided to try Praluent 75mg. I was hoping this would be more tolerable, well it was exactly the same. Don't know why, but both these inhibitors, caused multiple issues, as a matter if fact, I can't think of somewhere that didn't hurt. I have had several MRI over the last 20 years, strangely I had a CMRI when I was really sick with Praluent and for the first time there was gadolinium enhancement in the left ventricle suggesting inflammation. This had never been there before.
I am not saying the Praluent caused this, but I had a very bad inflammatory responce to both of these similar drugs. Absolutely horrific.
I am still having abdominal discomfort, with slight difficulty swallowing, chest discomfort and joint pain.
Multiple other side effects, point being that in my case had very very serious effects.
As with repatha, I will now have to wait for weeks for all this to settle down.
I started the Praluent 75mg injections in my legs on Sept. 7, 2018. I'm on my 13th injection. So far I don't notice any side effects. I do get muscle pain from statins. I take an over the counter pain pill to make the pain go away. Statins reduced my LDL from 200 to 80mg. Adding the Praluent lowered my LDL down from 80mg to 40 LDL very quickly. I'am very happy with the results and also the 60% price drop announced by the manufacturer coming in March 2019.
I am in my 3rd year of Praluent. It's nothing less than a miracle drug for me. It dropped my cholesterol from a start of around 250 to 107 on last test. I only inject once every three weeks instead of two. I'm going to a once a month injection starting with my next injection. 75mg.
I took it after trying about 4 different statins with horrible muscle cramping. Mainly in the legs and calf's. Absolutely no side effects with Praluent. I hope it works as well for you.
I'm a 72 year old man taking 75mg Praluent 75mg injections every other week for the last 6 months along with Lipitor statin 40mg daily. I get no side effects from the Praluent. I do get muscle pain from the 40 mg. Lipitor statin. Both of these meds have lowered my LDL (Bad Cholesterol) from 300 when I had my heart attack 1 year ago all the way down to 40mg/dl. Yes 40 ! Amazing stuff. Only complaint is the price of Praluent which the manufacturer has just announced a price reduction of over 60% beginning March 2019. I also take a pain pill every morning to make the slight muscle pain go away. I'm very happy with these results and plan on taking these meds forever even though there are side effects that I can tolerate.
Yes, I had pain radiating from shoulder with all statins. It wasn’t worth the pain given my levels were not too bad in the first place but cardiologist wanted lower due to aortic aneurysm. The Praluent works great but after several months I am developing uncomfortable levels of pain in my legs especially the leg where I inject most frequently. If this continues and I can pinpoint my problem to the drug. I’m discontinuing.
Your last post thank you very much it is nice to know, And like you said these new ones are very hard to answer until they have been out for awhile. And also since you had written you last post on the Praluent the doctors are using much more caution on the statins that cause severe leg and other cramps. Some people have stopped many statins and the cramps continue for who knows how long. thank you so much for adding this.
Just wanted to follow up on my question in February regarding Praluent and muscle pain. Most of us, I believe, are eager to hear what others with Familial Hypercholesterolemia have experienced after discontinuing statins owing to muscle pain and other side effects. I completed a trial of Praulent for about three months, but my doctor decided the small change in my cholesterol didn't warrant continuing. While there seems to be some question that Repatha will be anymore effective, I agreed to give Repatha a try and will share any useful results in a few months.
In regard to muscle pain with Praulent and Repatha, I think these two drugs are just too new to give anyone a clear picture of the scope of possible side effects.
I also want to respond to Celeste regarding her experience with exercise and suggest that she may want to search online for medical studies focusing on exercise and statins.
Thanks to everyone who has responded thus far.
Yes I have pain all the time, beside that I have memory loss and I lost too much weight as I was too thin to begin with.. Not my favorite drug but statins dont work with me
It's been about 6 months since I started Praluent and I haven't noticed any extra pain. I already have Fibromyalgia and arthritis in my back and was afraid of statins causing even more pain than I currently have. My LDL has gone down over 50 points and my triglycerides are almost normal. Hopefully it keeps working its magic and I don't have any problems.
yes. I stopped statins because they weren't working to lower my soaring LDLs and caused crippling muscle pain. I started Praluent to control my Familial Hypercholesterolemia with the hope of not having horrible muscle pain. After 9 months of injections, my LDLs are much lower, but I am having significant muscle aches and wonder if this miracle drug is worth the PAIN. I only agreed to take it because it wasn't supposed to cause muscle pain like the (useless) statins. SO, NOW WHAT? Discontinue Praluent & wait for a heart attack or stroke or continue to suffer horrific muscle pain? I joined a gym to get healthy, but am unbelievably sore after the lightest workout. HELP!!!
- Praluent uses and safety info
- Praluent information for Healthcare Professionals (includes dosage details)
- Side effects of Praluent (detailed)
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