Wellbutrin - Bupropion XL 150 make anyone else tired?

I am so glad I stumbled onto this thread! I have been on Bupropion XL for about 2 months. My Dr. recently increased my dosage from 150 mg to 300 mg. I just woke up after about 18 hrs of sleep and feel like I could go back to bed! I am calling my Dr. today. Thanks you for sharing everyone.
Since you have only been on this medication for 2 days , consider giving it more time and follow up with your Dr.

Wow. This little thread is an informative gem I'm thankful to have come across. I can only echo my experience of the same side effects others have already reported. Like a few here, my prescription for bupropion targeted ADHD (and depressive anxiety) to help boost motivation and keep me on task -- as an adjunct to a stimulant, no less. However I, too, experienced a sort of chronic fatigue -- an almost hypersomnolence that took on a narcoleptic force especially in the early to mid afternoons. I had to fight myself in trying not to nod off at my desk (even though I've always been more of an insomniac who can forget about even trying to fall asleep unless I'm at least in a comfortable, fully prone position). Likewise, it tended to give me an emotionally shorter fuse, although fortunately not incredibly so. FWIW, I seem to be sensitive to norepinephrine affective meds and have noticed similar side-effects from SNRIs, and the SSRI escitalopram. But it was surprising to experience this from what's also supposed to be a dopaminergic medication.

I have the same problem. Extremely sleepy throughout the day. I almost felt drunk kind of.

I have been taking sertraline for about 3 months. 150 mg of Bupropion was added 4 weeks ago and it makes me tired and hungry. I take it in the morning and the sertraline at night. I tried taking them both at night and I was tired the whole next day and could barely function. I am giving it a couple of months and will have the doctor discontinue it if this doesn't improve!!

I recently took Wellbutrin for about a month and a half. I took it in the morning and could not sleep at night. The funny thing was I could sleep in the daytime, but if I took it at night I could not sleep, even with sleeping pills. I felt extremely tired, fuzzy-headed and could not think clearly. I looked like I had not slept for a month. I decided to wait and see if this would pass. It only got worse. I quit taking it. It took about 3 weeks before that feeling passed. I still think I feel some effects of it, though it has been several weeks since I quit taking it. I also take Levothyroxine and think there is an interaction between them. I have ADD and it did not help with focusing, concentration, etc. I was physically active during this time. Physical activity made no difference in how I felt. I donate plasma and a sample of my blood was tested during the time I was on Wellbutrin. My plasma level was too low for me to donate. it took a few weeks to get my protein level up so I could donate again.

I’ve been taking Wellbutrin for about 3 months now and at the very beginning I almost stopped because it made me so anxious and jittery. I took it in the morning and had to stop drinking coffee. Over time the anxiety has gotten better and I’ve added my coffee back. But, now after I take it I do feel exhausted. That’s how I came across this thread because I looked up if it was possible for it to cause drowsiness. I’m glad it’s helped with the anxiety- My dr. replaced my Prozac with it which I was taking for anxiety and depression and I was skeptical because I had always heard it didn’t work so well on the anxiety aspect. Prozac was great for me for both for many years but out of nowhere it seemed to stop working. Anyhow, this week I plan on trying to take the Wellbutrin at night instead and see if that helps.

August 2019
Hello, I been on Wellbutrin 150 for 2 weeks now and I too get tired sleepy angry, and sad. My Doctor gave it to me for anxiety & to supress my compulsive eating. He told me it takes 2 months for the side effects to go away and calm me down. I will give it a 3 month trial and if it don't work by then I am going to switch. However, I found very helpful counselling sessions with a psychologst and most insurances will pay for it. Going 1x a week or every 2 weeks for 1 hour does help. Please try counselling along with your medications you will see a world of positive difference. Some programs have 6 weeks to 6 months free counselling if you don't have insurance. Dial 211 in your city to find out places that help. In our city in Florida it is the crisis center. Some churches offer counselling as well if you prefer faith based.
God bless all, hope this helped.

I've been on Wellbutrin 300xl and I've been getting tired a lot around noon and it could be because I haven’t been taking the sleeping pills they gave me so I can sleep good at night. Ask your doctor for Trazodone It helps you sleep through the night so you can feel well rested in the morning for when you do take the well Wellbutrin.

I've been on Wellbutrin 150xl for 1 week now and from the very first day of taking it, I felt like I hadn't slept in years. I was so tired even in the morning right after taking it. So, I've started taking it at night and wow the difference is incredible. I sleep great and wake up refreshed and feeling pretty good. I'm taking it for quitting smoking and I'm supposed to go up to 300xl once a day at this point (1 week after start of taking) and I wonder if there will be any change after the dose increase. It's so wild because my doctor said I was get energetic on this stuff but yeah, not me. Even Nyquil has the opposite effect on me ;)

I was just prescribed Bupropion and I kept thinking... why do I feel like I'm in a daze? And why so many headaches and feeling like a Raggedy Ann doll & wanting to fall asleep??
It seems suspiciously connected to how I feel mid afternoon. I could barely get home and can't eat my dinner; I'm just too tired!
Signed - going to lay down shortly...

I was weaned off of 40mg of Citalopram because I wanted my libido back. Am taking 150mg XL of Wellbutrin now for over a month. I am exhausted most of the day. At first, I didn't make the connection that perhaps it was the Wellbutrin that made me so tired. I am going back to Citalopram. I do not want to be this tired all the time. I did try taking the Wellbutrin at night, and fell to sleep quickly. However, I am still tired during the day. I have decided it is not worth it being so tired all the time. I would rather have my usual energy than libido. Going back to Citalopram.

So today was my first day taking Wellbutrin 150mg XL once daily in the morning. Thirty minutes after taking it at 8am, I found myself in a raging mood where I was screaming like a maniac at my kids. I took my daughter to the hair salon to get her hair done and fell asleep in the chair, I have never done this before. The stylist had to wake me up to let me know he was finished with her hair and I was so embarrassed. I nearly crashed my car on the way home from the salon because I was so drowsy. I have to get off of this medication, I drank 3 cups of coffee today and still feel exhausted and I usually drink 1 cup a day and feel fine. This is the worst medication ever and I can’t be around my children using this.

You will probably feel tired for up to a couple weeks and until your body gets used to it. I seem to have the opposite reactions with this med. It gave me extra energy , but I had crazy carb cravings in the afternoon and had a hard time at 1st sleeping at night. I have been on it for 6 months now and everything has leveled out except that the past 2 weeks , all of a sudden about 2 to 3:00 in the afternoon, I am just exhausted. if I sit down on the couch I will fall asleep, if I lay down I am out for like 3 hours. Like all meds, everyone responds differently. I am now at 6 mths, where you are with the afternoon tiredness, but I did not start that way. You will probably not feel like this in a few weeks. If so, let your Dr know