Today is my 2nd day on bupropion 150 sr for major depression. I've been depressed for 2 yrs after my dad's horrible death.The doc said that in a couple of days I could take a 2nd 150sr pill. I was tired before trying this AD, but now it's worse. I still take Klonopin 1 mg at nite to actually fall asleep. The SSRIs have stopped working for me. I really do feel hopeless. I don't understand why I'm taking something that is supposed to be energizing & I'm more tired. I don't know if the bupropion 150 xl would of been better. I cannot find a good psych on my insurance so I go to a GP.