I have been taking Bupropion XL 150 for only 2 days. It was prescribed to treat depression, fatigue, confusion, etc. I take it around 8am. I do not really feel any effect, except I am completely wiped out by early afternoon. This wasn't the case prior to starting this medication. The past 2 days I have napped at 3 pm, then back to bed by 9 pm. Has anyone else experienced similar results? Over time will this subside, or is this the wrong medication for me?
Wellbutrin - Bupropion XL 150 make anyone else tired?
Question posted by A2Eureka on 16 Feb 2014
Last updated on 28 August 2022 by Gene toyota
Yes ! After about 2 years I've noticed it went from giving me energy to making me feel sleepy in the afternoon. I was looking around for this question.
I am so glad I looked this up before picking up my next prescription. I was on 300mg and doing ok-ish but doctor added a 150mg to the 300 (total 450mg) and I cannot function. It is killing me at work. Taking them later in the day now so as to be able to be 'present' at my job.
After reading this, I'm going to stop taking the 150mg and go back to 300.
I'm going to ask my doctor about this newly FDA approved Auvelity for depression. It does not cause weight gain so if it can help with PTSD, I'm going off the Wellbutrin.
One Year Experience: I've been on generic 300xl for about a year and (41F) it still makes me absolutely exhausted. I take it in the morning, and within 3 hours feel extremely heavy and tired. At 6 hours I can't keep eyes open, like I've taken a sleeping pill. I also don't seem to have as much appetite control on it.
If I take on empty stomach, and drink a lot of water, it's a bit better. I've been attempting to get on name brand as I hear some have luck with that as opposed to generic, but it's been difficult with insurance. I might try a different generic as I hear that's helped people that experience the sleeping pill side effect. Like many others have experienced here, my doc is confused about it.
I take it for PTSD/chronic depression/anxiety, and Wellbutrin is the only AD I would try because of fear of weight gain/loss of sex drive. Libido is fine, weight gain is about 5lbs that I can't shake. **It gives me positive space from PTSD symptoms, which were really severe, so I continue to take it.**
Been on 300mg of Wellbutrin for about 7 weeks... And yes, it has been making me sedated for at least the last 4 months...
I was actually just about to ask that same question. My answer is yes. It makes me tired enough to pass out in the middle of the day as well. Including all day drowsiness. Only difference is, i was on the 75 mg. I was told by mutiple doctors that for most people it had the opposite effect. Now my doc suggested to increase the mg to 150 saying the increase would help with the drowsiness. Both scripts were instructed to take 1 a day. So instead of one every morning, i started taking it before bed and it would help me fall asleep. I havent started the 150mg yet but now I'm worried after this. Maybe we are wired different. Im curious if someone else has taken the same dosage from 75mg-150mg and felt a difference from one to the other starting off drowsy to not. Hope i could help in some small way. Goodluck!
My history with bupropion xl 150mg goes back 2 years (2019). At first, wonderful. More energetic. Suffer from bipolar depression anxiety panic disorder insomnia. 2 months later, extremely tired. Just wanted to stay in bed. Told dr, so he increased to 300mg xl in the morning, and 150mg xl at noon. I became more tired, depression worsened, gained weight, helplessness. Found a way after sleeping 14 hrs a day to research the different generic manufacturers. Theres several, and pharmacy kept switching up on me. After 2 years let me tell u that CIPLA is the best. I tried sandoz, par, lupin, mylan, all of them. TRY CIPLA! My fatigue and joint pain and all other terrible side effects subsided. Also take Lexapro buspar and 5mg of abilify. Hope this helps you. I thought i was dying while taking other bupropion xl generics. Like i was being poisoned. Try Cipla
I've taken Wellbutrin xl off & on for 15 years. I haven't taken it in 7 years. With the pandemic (2020) and winter coming I decided to try it again. I completely forgot how tired it makes me.
I have Seasonal Affective Disorder, ADHD, and PTSD. I don't take any other medications. In the past I have tried an adderall/wellbutrin combo. The Adderall made me sleepy too. I would take both at night. For now I only take Wellbutrin XL beginning 2 days ago.
I forgot that I used to take this Wellbutrin XL at night instead of day so the first time I took it at noon and I was so tired. The next day I took it at night and the next morning I woke up feeling so refreshed and not groggy as I normally do without medication.
I noticed with this medication I breathe more deeply and easily which makes sense that I would get more restful sleep with full deep breathes.
And I was able to tolerate going out in 28° weather with my kid and dog in the afternoon. I was able to resist impulse shopping online. I didn't need to take extra strength Tylenol for headaches. I was able to get housework done without extreme body pains and inflammation. I forgot what a little miracle this medication can be for me.
I've been taking Wellbutrin for the past 3 years off and on and being tired and sleepy has never been a side effect for me, unless my depression symptoms were triggered and I re-lapsed into another episode.
I have in the past with the guidance of my doctor taken Wellbutrin with Lexapro and have tried other anti-depressants in the same classification, but made me extremely fatigued and apathetic. I could barely get anything done in a day, but my depression and anxiety were completely lifted. Wellbutrin worked miraculously well for me for the first year or so, then I would experience a relapse that was severe enough, which led me back to the doctor's office.
For those just taking it, I had awful side effects. My heart was racing, I experienced tinnitus (ringing in the ears), sweating profusely, etc. In the past, my doctor tried putting me on 300, but it made me dizzy and exacerbated all those side effects I previously mentioned to the point where it was unmanageable. I was experiencing awful anxiety at 300, where I couldn't make it to the point where the side effects would subside.
Anyway, with that being said, like all anti-depressants if you don't see improvement past several weeks, I would go back to the drawing board. Tiredness is a side effect I have not experienced, which means it's time for me to see my doctor. Good luck on your journey.
Although this doesn't apply to every answer here, I've noticed that many people are on both SSRI's and Bupropion (Wellbutrin) at the same time. It is a known phenomenon that Bupropion can potentiate (increase the effect of) SSRI's. So if you are on Prozac for example, what would have simply reduced your anxiety now completely sedates you. I had this experience with Ritalin and Fluoxetine... Ritalin also being a dopamine reuptake inhibitor like Wellbutrin.
I came looking for this because I am also taking Wellbutrin. I've only been on it for a week now and have definitely noticed that I'm waking up tired. However, I also know that my caffeine has increased (increases chances of the afternoon crash) and my water intake has decreased. Was taking dexamphetamine for a while and it did the same thing with regards to the afternoon crash, only to a greater degree.
Before stopping your meds, I would recommend to everyone that you make as much effort as possible to do all the basics... lots of water, exercise, try as hard as possible to get your necessary calories in. If you need caffeine, try and get the extended release capsules rather than smashing cappuccinos in the morning.
I have been on Wellbutrin XL 150mg every night for 3 months.
This was added to my already existing sertraline 200mg nightly.
My anxiety and depression have drastically improved, however I cannot get past the EXTREME EXHAUSTION.
I was hoping it would go away.
I spoke with my Dr about it and she said that this was not a symptom of Wellbutrin and that it should have the opposite effect and make me more awake.
I seriously believe that this is truly a symptom from Wellbutrin.
I have NEVER been this exhausted before.
I literally CANNOT open my eyes in the morning or get out of bed.
I am happy that my anxiety has improved as well as libido, but this extreme exhaustion is potentially not worth it.
Has anyone come out of this fog or do I go back to being sad and anxious?
Same thing here! Day 4 of Wellbutrin 150 and I’m not in a fog but I am extremely tired by about 2-3pm. I take my medicine in the morning. I am completely wiped out! I hope this fades! On the upside, I’m sleeping SO well at night!
I have the EXACT same symptoms. I literally cannot keep my eyes open during the middle of the day. I have been taking a 2-3 hour nap and going to bed early, still exhausted. I was told that wellbutrin would if anything, have the opposite effect and give me energy. I am wondering if this is not the right drug for me as well. It was prescribed to me for adult ADD. I have not noticed any difference in my symptoms. I am just extremely tired ALL THE TIME.
I am so glad I stumbled onto this thread! I have been on Bupropion XL for about 2 months. My Dr. recently increased my dosage from 150 mg to 300 mg. I just woke up after about 18 hrs of sleep and feel like I could go back to bed! I am calling my Dr. today. Thanks you for sharing everyone.
Since you have only been on this medication for 2 days , consider giving it more time and follow up with your Dr.
I'm amazed at how many people are experiencing tiredness on Bupropion, while their doctors are saying they d' never heard of it as a side effect of this particular medication. I'm no exception here. I'm currently in week 7 of Bupropion 150mg and weighing out the pros and cons. It worked wonders for me in the first 5 weeks; I felt energized, balanced, and productive, but not manic or 'synthetic', just the best version of myself. It didn't interfere with my sleep or sex drive and basically didn't give me any side effects at all. After 3-4 weeks, I started experiencing memory issues. At one point, I couldn't even remember the name of one of our dogs! Finally, week 6 was the end of the honeymoon and I started feeling extremely tired and rather sad. I found myself crying over some ancient wounds and traumas, not being able to work, feeling extremely sluggish, and sleeping up to 12 hours a day.
I am also experiencing mild palpitations and my blood sugar levels seem a bit erratic. I'm trying to stick it out, hoping the pros will return but am not too optimistic. This happened with other antidepressants in the past, namely Citalopram and Sertraline, and I always had to stop using them as fatigue and drowsiness were just too much, even after 3-4 months.
Wow. This little thread is an informative gem I'm thankful to have come across. I can only echo my experience of the same side effects others have already reported. Like a few here, my prescription for bupropion targeted ADHD (and depressive anxiety) to help boost motivation and keep me on task -- as an adjunct to a stimulant, no less. However I, too, experienced a sort of chronic fatigue -- an almost hypersomnolence that took on a narcoleptic force especially in the early to mid afternoons. I had to fight myself in trying not to nod off at my desk (even though I've always been more of an insomniac who can forget about even trying to fall asleep unless I'm at least in a comfortable, fully prone position). Likewise, it tended to give me an emotionally shorter fuse, although fortunately not incredibly so. FWIW, I seem to be sensitive to norepinephrine affective meds and have noticed similar side-effects from SNRIs, and the SSRI escitalopram. But it was surprising to experience this from what's also supposed to be a dopaminergic medication.
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