I was prescibed prednisone for serious sinus issues; 60 mgs. for 5 days and gradually tapering off over 14 days total. About 1/2 way through I began feeling deeply dipressed and had quick weight gain. Since I had quit smoking only 8 weeks previous to this, I had already gained some weight but felt I had my eating back under control. I had also been using Zyban to help me through the quitting smoking but had stopped just a day or 2 before starting this prednisone regimen. At the thime, I thought my depression was a result of the weight gain which I blamed on the non-smoking/metabolism shift(?). Never the less, I was a mess; crying all the time, not wanting to be around anyone, exhausted. I had such an argument with my daughter and husband, I ran out and bought cigarettes and smoked! Stupid, I know but I was definately out of control. As the days went by and the depression got worse I decided to check the side effects for prednisone. Could this REALLY be a result of the prednisone? I've been off it now for 10 days and I still don't feel much better yet. I don't seem to be still gaining weight but I am still depressed. Does anyone know how long it takes for this to be totally out of your system? Any info would be greatly appreciated
Can prednisone cause depression and how long does it take to get out of your system?
- Asked
- 23 Jul 2012 by upset in Boston
- Updated
- 3 July 2018 (6 weeks ago)
- Topics
- depression, prednisone
Responses (13)
Yes, yes, yes. Prednisone causes emotional changes and increased anxiety. Especially at your level. Call the doctor and tell him about your side effects. He should be able to give you something like Xanax to get you through this time. It helps one feel back in control of ones moods.
You figured out most the issues. Keep a low salt diet to reduce the water weight gained. Good news is when you end, the weight will drop off.
At sixty you will be pretty hyper. Stay away from anything disturbing including films, TV and switch to only happy things. Read, rest. You can do this. Getting healthy is the goal. Glad it will be temporary. Oh, and be sure you talk with family so they know this is not the normal you and that the meds do this. It does help things go smoother.
Your friend, endless prednisone, getting through seven years of this med and stayin' alive. Karen
Upset .. Prednisone does cause depression, as well stays in your system for a long time, but since you were on it a short time it could maybe stay in your body for about 2 to 3 weeks. Drinking plenty of water will help you to flush it out of your system. The Zyban (Wellbutrin) should help you with your depression, however, it may cause you to be nervous, and hyper, Also prednisone can also cause the feelings of nervousness, so try taking the Zyban before 2:00 pm. You may want to ask the doctor to give you an antidepressant while you are having those feelings. If it were me I would try to stay away from Xanax as it is very addicting and hell to get off of. I hope this has helped... pamee
FYI. Low dose Xanax is not an issue when on this drug as it is temporary in this situation. Higher doses for anxiety disorders can cause problems as they are long term. All it does is counteract the fast heart rate and quick mood changes for the month or so one is on this.
Regarding how long it is in your system is not the problem. Half life is reasonablely short. The issue is that the adrenals shut down when over ten mg. In a month they shrink a bit. In long term use it can take months to years to recover. In this case, the immune system is most affected as the adrenals will recover fairly quickly. After use of prednisone one needs to remind a physician about it for six months or longer about the use of this med as the ability to fight infections has been compromised.
This was explained to me by my doctor. Hopefully I have phrased it correctly. Karen
Thank you ALL for the great info. I did go back on the Zyban yesterday, hoping that might help lift my spirits and help me back OFF the cigarettes! It was really difficult to quit smoking and having 8 weeks under my belt - I'm so disappointed that I allowed myself to fall back. For me, having an idea of how long I might suffer with these side effects (ie. how long the prednisone stays in my system), really helps me to go forward. If it was going to be 6 months, I would go directly to my GP and insist on something to counteract it. Since it should only be a couple more weeks, I will try the zyban and just wait it out. I will mention the problems when I see the ENT specialist next week who prescribed it. If she feels I need something more - I will consider it. Again, I can't thank you enough for helping me get through this!
Upset, Give yourself a pat on the back for stopping the smoking. It's great you went back on zyban. It's a great med to stop smoking. I wish you the best of luck for your smoking cessation and wish you well on your depression... God bless.
pamee
Thank you friends!
Absoluely!!! It will pass. Be sure to advice your dr that the steriods are affecting your mental health. Im not sure how long they stay in your system but I do know it is a decent amount of time. They keep on working after you stop taking them for quite a while is what I mean. good luck and remember, its just the meds..youre ok!
*advise
I took Prednisone for 4 days for my hairtransplant surgery and after the 3 day my panic attack and anxiety kicked in. I had anxiety in the past and have been on effexor 75mg for my tinnitus,and this thing totally made me feel bad. After 4-6 weeks, I still feel very anxious and my doctor gave me xanax to cope, but it makes me feel tired..
IT's A TERRIBLE DRUG AND SHOULD BE BANNED.
Why don't doctors check w patients first before prescribing this crap?
I agree... my ears, nose & throat specialist NEVER even mentioned the possible side affects. Had she, I would have insisted on something else. I cancelled my sinus surgery because she told me I'd need to go on it again beforehand. I've struggled with depression for many years; I'd say it was dangerous for me to be put on prednisone.
very true... same here and I have been taking effexor 75mg and at one point 150mg to cope with the anxiety of Tinitus and Prednisone, made me all depressed and anxious, and I am off of it for almost 2 Months, but because I had past anxiety episodes, it brought back all the fearful memories and churning in the stomach and hopelessness... I am still baffled and outraged at my Hairtransplant Dr. because he saw that I was taking Effexor and should have been careful with prescribing this awful drug.
Is there anywhere more information whether Prednisone has long-term psychological effects?
I was on prednisone two months ago, when I was on it I felt edgie so the Dr put me on Zoloft. Wow what a trip I put myself in the hospital thinking I was going nuts. I was in for 5 days when I got out I was fine, then the doctor changed my meds agian on me. Now I feel anxious and depressed, can meds really screw people up? I have been on prednisone before but never noticed the depression, agitation and anxious feelings. Or am I nuts?
YES yes yes. Meds can screw you up big time! I am going throught the same thing you are. Do Not think it is you or your fault.
Did the depression go away? How long did it take? I was on a high dose for 2 months for back pain. I came off it last week and now I'm in a pit of depression and anxiety. I've suffered really badly from this in the past so all the old feelings and thoughts are coming back. The doc put me back on the steroids 3 days ago and also on beta blockers but nothing is working. I've been on antidepressants most of my life.
Wow. I wish I was told having a pure mental break down. I am now hungry all the time and crying or anxious. The person I am dating does not know what is wrong but I thought I would research and the only thing different was the predisone. Today is my last day on them and I hope it stops!!!
I believe the depression does not come from the medication itself, but rather the physics side effects. I have Addison’s, and recently got a bad cold that triggered my asthma. I was in the hospital for 5 days on mega doses of prednisone. Needless to say by the time I left the hospital I already had the moon face, and the apple belly (that wasn’t helping with my breathing either). When I got here nw and looked in the mirror I started crying. Who was that person? Because it didn’t look like me. On top of everything else I also got acne, another cortisone side effect. I have spiraled into a depression that I don’t want to leave the house. I’m seriously considering stopping all my medications, and let nature take its course. This isn’t quality of life. The lower back pains alone (another cortisone side effect) make it hard to get around.
Try being bipolar and having severe reoccurring episodes of bronchitis because you have GERD and gastroparesis. The only thing that gets me well is steroids but it wrecks hell on my mental health. Steroids are known to send people who are bipolar one of two ways they either can go manic or they can go into deep depression. But frankly I don't have a choice nothing else works.
SIMILAR REACTION: I know this was posted in 2012 and I hope all is well with you. I’m simply posting here because I went through a similar issue. I had taken prednisone when I was a kid and had no problems. October 2016 I had to take prednisone due to asthmatic issues. As a result I had terrible anxiety, palpitations, and depression just days in. THIS IS NOT THE CASE FOR EVERYBODY WHO TAKES PREDNISONE BUT HERES WHERE MY STORY GETS TRICKY. After 8 months of having anxiety/depression, muscle twitches, headaches, flu like symptoms, and insomnia and seeing multiple doctors who told me there was nothing wrong with me and just prescribed me antidepressants I had come across an article on Lyme disease. I saw a Lyme specialist and that’s what I had! The prednisone-a steroid- brought out all my symptoms at once because Lyme disease can lay dormant in your body for years.
Further Information
- Prednisone Information for Consumers
- Prednisone Information for Healthcare Professionals (includes dosage details)
- Side Effects of Prednisone (detailed)
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Can long term high doses of Prednisone cause long term, possibly permenent depression? I was diagnosed with Rheumatoid at age 5. A very severe case which in time destroyed every one of my joints. Anyway because I had fluid build up around the heart wall, they put me on massive doses of prednisone at age 7 that lasted until I was 18. Every year it tapered off but for 5 years I probably took close to 20 to 28 prednisone pills a day.
I see all the people that are suffering from long term use of prednisone and the problems. Has anyone truly told you the effects on your body and why. I went with my husband who truly felt he was dieing because of pain, anxiety, muscle spasm and depression to the doctors and I says doctors because we saw everyone to find out what was wrong with him. As it turns out when you are on long term use your adrenal glands stop working on their own which is necessary to fight stress, even just deal with stress, ruins your metabolism, gives you pains and spasms you never had before and when you see a doctor or ER they look at you like you are crazy but no one checks for Cushing's syndrome which is from Prednisone. Look it up and although it can be reversed most times not all but most, it is a long a painful scary battle so if you do not need to be on prednisone please avoid like the plague or at least take it for the least amount of time.
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My husbands doc actually admitted that although he prescribes it he would never take it. Can you believe that... Well stay strong and remember the battle is long, like 6 months for my husband but we will battle it together. Stay close to those who will help you and run from those who will aggravate the situation.
Ive been on predisone for 4 years for my kidney two months ago i was on a wean off 15mg to 10mg to 5mg then 1mg i got really ill so the renal doctor put me on 20mg been on the 20 for nearly a month ive been feeling reallly depressed these last 2 weeks i cant concentrate i get angry real quick feels like a cloud sadness just dropped on me crying nearly everyday next i notice ive got a bald patch on my head and its getting bigger my hairs falling out went to see a hair specialist friday he said its probably the long term predisone and stress can cause this on top of predisone ... sooo frustrated right now