I've tried the pill in many different forms, and I've experimeced relatively low amounts of weight gain no more than 5-7 lbs but I am getting older now and my schedule is so out of whack I want to make my life easier without having to remember to take a pill every day. I've read a lot of women experience weight gain with the depo shot. I'm trying to get into great shape and actually loose some weight so I want to hear any testimonials about preventing weight gain on the depo shot or if it's inevitable.