Generic Name: hydrochlorothiazide and aliskiren (HYE droe KLOR oh THYE a zide and a LIS ke rin)
Brand Names: Tekturna HCT
What is Tekturna HCT?
Tekturna HCT contains a combination of hydrochlorothiazide and aliskiren. Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.
Aliskiren (Tekturna) is an anti-hypertensive (blood pressure lowering) medication. It works by decreasing substances in the body that narrow blood vessels and raise blood pressure.
Tekturna HCT is used to treat high blood pressure (hypertension).
Tekturna HCT may also be used for purposes not listed in this medication guide.
You should not use Tekturna HCT if you are allergic to aliskiren or hydrochlorothiazide, if you are unable to urinate, or if you are also using itraconazole (Sporanox) or cyclosporine (Gengraf, Neoral, Sandimmune). FDA pregnancy category D. Do not use Tekturna HCT if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant.
Before you take Tekturna HCT, tell your doctor if you have asthma, low or high levels of potassium in your blood, kidney or liver disease, glaucoma, gout, lupus, diabetes, or an allergy to sulfa drugs or penicillin.
Do not use potassium supplements or salt substitutes while you are taking Tekturna HCT, unless your doctor has told you to. It may take up to 4 weeks for this medication to control your blood pressure. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
Before taking this medicine
You should not use Tekturna HCT if:
you are allergic to aliskiren (Tekturna) or hydrochlorothiazide (Carozide, Diaqua, Ezide HCTZ, HydroDiuril, Microzide, and others);
you are unable to urinate; or
you are also using itraconazole (Sporanox) or cyclosporine (Gengraf, Neoral, Sandimmune).
If you have diabetes or kidney disease, you may not be able to take Tekturna HCT if you are also taking any of the following heart or blood pressure medications:
azilsartan (Edarbi, Edarbyclor), candesartan (Atacand), eprosartan (Teveten), irbesartan (Avapro, Avalide), losartan (Cozaar, Hyzaar), olmesartan (Benicar), valsartan (Diovan), telmisartan (Micardis); or
benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril.
To make sure you can safely take Tekturna HCT, tell your doctor if you have any of these other conditions:
low or high levels of potassium in your blood;
- kidney disease;
- liver disease;
systemic lupus erythematosus (SLE);
an allergy to sulfa drugs or penicillin.
FDA pregnancy category D. Do not use Tekturna HCT if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant. Tekturna HCT can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control while taking Tekturna HCT. It is not known whether hydrochlorothiazide or aliskiren passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using Tekturna HCT. Do not give this medication to anyone under 18 years old without medical advice.
See also: Pregnancy and breastfeeding warnings (in more detail)
How should I take Tekturna HCT?
Take Tekturna HCT exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get the best results from Tekturna HCT.
You may take Tekturna HCT with or without food, but take it the same way every time.
Conditions that may cause very low blood pressure include: vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low salt diet, or taking diuretics (water pills). Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.
Your blood pressure will need to be checked often. Visit your doctor regularly.
It may take up to 4 weeks for Tekturna HCT to control your blood pressure. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
High blood pressure is sometimes treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.
If you need surgery or medical tests, tell the doctor ahead of time that you are taking medication that contains hydrochlorothiazide. You may need to stop using Tekturna HCT for a short time.
Store Tekturna HCT at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include dry mouth, increased thirst, drowsiness, restless feeling, confusion, nausea, vomiting, increased urination, muscle pain or weakness, fast heart rate, feeling light-headed, fainting, or seizure (convulsions).
What should I avoid?
Avoid taking this medication with a high-fat meal, which can make it harder for your body to absorb Tekturna HCT.
Do not use potassium supplements or salt substitutes while you are taking Tekturna HCT, unless your doctor has told you to.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Drinking alcohol can further lower your blood pressure and may increase certain side effects of Tekturna HCT.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
Tekturna HCT side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Tekturna HCT: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using Tekturna HCT and call your doctor at once if you have a serious side effect such as:
eye pain, vision problems;
feeling like you might pass out;
high potassium (slow heart rate, weak pulse, muscle weakness, tingly feeling);
low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling);
urinating less than usual, or not at all;
joint pain or swelling with fever, swollen glands, muscle aches, nausea, vomiting, chest pain, unusual thoughts or behavior, and/or seizure (convulsions); or
severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Less serious Tekturna HCT side effects may include:
dizziness, spinning sensation;
diarrhea, stomach pain, indigestion;
flu symptoms; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Tekturna HCT?
Tell your doctor about all other medicines you use, especially:
lithium (Eskalith, Lithobid);
a blood thinner such as warfarin (Coumadin, Jantoven);
aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others;
a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton);
cholesterol medication such as atorvastatin (Lipitor), cholestyramine (Prevalite, Questran) or colestipol (Colestid);
insulin or diabetes medicine you take by mouth; or
steroid medication such as prednisone (Deltasone, Sterapred), methylprednisolone (Medrol), fluticasone (Advair , Flonase, Flovent, Veramyst), beclomethasone (Qvar), budesonide (Pulmicort, Rhinocort, Symbicort), dexamethasone (Cortastat, Dexasone, Solurex, DexPak), mometasone (Asmanex, Nasonex), triamcinolone (Nasacort), and others.
This list is not complete and other drugs may interact with Tekturna HCT. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
More about Tekturna HCT (aliskiren / hydrochlorothiazide)
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about Tekturna HCT.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Tekturna HCT only for the indication prescribed.
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.
Copyright 1996-2014 Cerner Multum, Inc. Version: 3.02. Revision: 2012-11-27, 11:15:42 AM.