Teflaro Side Effects

Generic Name: ceftaroline

Note: This page contains side effects data for the generic drug ceftaroline. It is possible that some of the dosage forms included below may not apply to the brand name Teflaro.

It is possible that some side effects of Teflaro may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to ceftaroline: intravenous powder for solution

As well as its needed effects, ceftaroline (the active ingredient contained in Teflaro) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking ceftaroline, check with your doctor or nurse immediately:

More common
  • Back, leg, or stomach pains
  • bleeding gums
  • chills
  • dark urine
  • difficulty with breathing
  • fever
  • general body swelling
  • headache
  • loss of appetite
  • nausea or vomiting
  • nosebleeds
  • pale skin
  • sore throat
  • unusual tiredness or weakness
  • yellowing of the eyes or skin
Less common
  • Abdominal or stomach tenderness
  • black, tarry stools
  • blood in the urine or stools
  • bluish color
  • changes in skin color
  • chest pain or discomfort
  • confusion
  • convulsions
  • cough
  • decreased frequency or amount of urine
  • diarrhea
  • difficulty with swallowing
  • dizziness
  • dry mouth
  • fast, irregular, pounding, or racing heartbeat or pulse
  • general tiredness and weakness
  • hives
  • increased blood pressure
  • increased thirst
  • itching
  • light-colored stools
  • lightheadedness, dizziness, or fainting
  • lower back or side pain
  • mood changes
  • muscle pain or cramps
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • painful or difficult urination
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • severe abdominal or stomach cramps and pain
  • shortness of breath
  • skin itching, rash, or redness
  • slow or irregular heartbeat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swelling of the face, throat, fingers, or lower legs
  • swollen glands
  • tenderness
  • tightness in the chest
  • troubled breathing
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • upper right abdominal or stomach pain
  • watery and severe diarrhea, which may also be bloody
  • weakness or heaviness of the legs
  • weight gain
  • wheezing

Some ceftaroline side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common
  • Blurred vision
  • difficulty having a bowel movement (stool)
  • flushed, dry skin fruit-like breath odor
  • hives or welts
  • increased hunger
  • increased urination
  • sweating
  • unexplained weight loss

For Healthcare Professionals

Applies to ceftaroline: intravenous powder for injection

General

The most common side effects reported in patients receiving ceftaroline (the active ingredient contained in Teflaro) were diarrhea, nausea, and rash. During clinical trials, serious side effects were reported in 7.5% of patients receiving ceftaroline and 7.7% of patients receiving comparator drugs. In both treatment groups, the most common serious side effects were in the respiratory and infection system organ classes. Treatment was discontinued due to side effects in 2.7% of patients receiving ceftaroline and 3.7% of patients receiving comparator drugs. Hypersensitivity was the most common side effect leading to discontinuation in both treatment groups.[Ref]

Gastrointestinal

Common (1% to 10%): Diarrhea (5%), nausea (4%), constipation (2%), vomiting (2%), abdominal pain (less than 2%), Clostridium difficile colitis (less than 2%)
Frequency not reported: C difficile associated diarrhea[Ref]

Dermatologic

Common (1% to 10%): Rash (3%), urticaria (less than 2%)[Ref]

Metabolic

Common (1% to 10%): Hypokalemia (2%), hyperglycemia (less than 2%), hyperkalemia (less than 2%)[Ref]

Cardiovascular

Common (1% to 10%): Phlebitis (2%), bradycardia (less than 2%), palpitations (less than 2%)[Ref]

Hepatic

Common (1% to 10%): Increased transaminases (2%), hepatitis (less than 2%)[Ref]

Hypersensitivity

Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported with beta-lactam antibacterials.[Ref]

Common (1% to 10%): Hypersensitivity (less than 2%), anaphylaxis (less than 2%)
Frequency not reported: Anaphylactoid reactions[Ref]

Renal

Common (1% to 10%): Renal failure (less than 2%)[Ref]

Hematologic

Common (1% to 10%): Anemia (less than 2%), eosinophilia (less than 2%), neutropenia (less than 2%), thrombocytopenia (less than 2%)[Ref]

Nervous system

Common (1% to 10%): Dizziness (less than 2%), convulsion (less than 2%)[Ref]

Other

Common (1% to 10%): Pyrexia (less than 2%)
Frequency not reported: Direct Coombs' test seroconversion[Ref]

References

1. "Product Information. Teflaro (ceftaroline)." Forest Pharmaceuticals, St. Louis, MO.

2. "Ceftaroline fosamil (Teflaro) - a new IV cephalosporin." Med Lett Drugs Ther 53 (2011): 5-6

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