Suprax Side Effects

Generic Name: cefixime

Note: This page contains side effects data for the generic drug cefixime. It is possible that some of the dosage forms included below may not apply to the brand name Suprax.

It is possible that some side effects of Suprax may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to cefixime: oral capsule, oral powder for suspension, oral tablet, oral tablet chewable

As well as its needed effects, cefixime (the active ingredient contained in Suprax) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking cefixime, check with your doctor immediately:

More common
  • Diarrhea
  • loose or frequent stools
Less common
  • Abdominal or stomach pain
  • agitation
  • black, tarry stools
  • bleeding gums
  • blistering, peeling, or loosening of the skin
  • blood in the urine or stools
  • chest pain
  • chills
  • clay-colored stools
  • coma
  • confusion
  • cough
  • dark urine
  • decreased urine output
  • depression
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • feeling of discomfort
  • fever
  • general tiredness and weakness
  • headache
  • hives
  • hostility
  • inflammation of the joints
  • irritability
  • itching
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lethargy
  • light-colored stools
  • loss of appetite
  • lower back or side pain
  • muscle aches
  • muscle twitching
  • nausea and vomiting
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid weight gain
  • rash
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • seizures
  • shortness of breath
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stupor
  • swelling of the face, ankles, or hands
  • swollen glands
  • swollen lymph glands
  • tightness in the chest
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • upper right abdominal or stomach pain
  • vomiting of blood
  • wheezing
  • yellow eyes or skin
Incidence not known
  • Abdominal or stomach cramps or tenderness
  • back, leg, or stomach pains
  • cough or hoarseness
  • coughing up blood
  • diarrhea, watery and severe, which may also be bloody
  • difficulty with breathing
  • general body swelling
  • increased menstrual flow or vaginal bleeding
  • increased thirst
  • nosebleeds
  • pain paralysis
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • sudden decrease in the amount of urine
  • unpleasant breath odor
  • unusual weight loss

Some cefixime side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common
  • Acid or sour stomach
  • belching
  • bloated
  • excess air or gas in the stomach or intestines
  • full feeling
  • heartburn
  • hives or welts
  • indigestion
  • itching of the vagina or genital area itching or pain of the genital area
  • pain during sexual intercourse
  • passing gas
  • redness of the skin
  • stomach discomfort, upset, or pain
  • thick, white vaginal discharge with no odor or with a mild odor
  • white patches in the mouth or throat or on the tongue
  • white patches with diaper rash

For Healthcare Professionals

Applies to cefixime: oral capsule, oral powder for reconstitution, oral tablet, oral tablet chewable


Cefixime (the active ingredient contained in Suprax) is generally well-tolerated.


Pseudomembranous colitis may occur during or after treatment with cefixime (the active ingredient contained in Suprax)

Gastrointestinal side effects have included diarrhea (16%), nausea (7%), loose or frequent stools (6%), flatulence (4%), abdominal pain (3%), dyspepsia (3%), vomiting, and pseudomembranous colitis.


Hypersensitivity reactions have included urticaria, rash, pruritus, drug fever, angioedema, facial edema, erythema multiforme, Stevens-Johnson syndrome, serum sickness-like reactions, and toxic epidermal necrolysis. Anaphylactic and anaphylactoid reactions, including shock and fatalities, have also been reported.

A case of occupational contact dermatitis due to cephalosporin allergy has been reported in a nurse who prepared cephalosporin solutions for administration to patients. The dermatitis resolved after the nurse stopped preparing the solutions.

Nervous system

Nervous system side effects have included headache, dizziness, somnolence, and seizures. At least one case of encephalopathy has been reported.


Renal side effects have included transient rises in serum BUN and creatinine, and acute renal failure. Cephalosporin class antibiotics have been associated with renal dysfunction and toxic nephropathy.

Interstitial nephritis has been reported rarely in association with other cephalosporins. Fever, azotemia, pyuria, and eosinophiluria are the hallmarks of this disorder.


Hematologic side effects have included transient thrombocytopenia, eosinophilia, leukopenia, neutropenia, and prothrombin time prolongation. Cephalosporin class antibiotics have been associated with aplastic anemia, hemolytic anemia, hemorrhage, positive direct Coombs test, pancytopenia, and agranulocytosis.


Hepatic side effects have included hepatitis, jaundice, and transient increases in SGPT, SGOT, and alkaline phosphatase. Cephalosporin class antibiotics have been associated with hepatic dysfunction including cholestasis.


Metabolic side effects have included hyperbilirubinemia. Cephalosporin class antibiotics have been associated with increases in LDH.


Genitourinary side effects have included genital pruritus, vaginitis, and candidiasis.


Cephalosporin class antibiotics have been associated with superinfection.

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