Suprax Dosage

Generic name: cefixime
Dosage form: tablet, tablet chewable, capsule, powder for oral suspension

See also:

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Adults

The recommended dose of cefixime is 400 mg daily. This may be given as a 400 mg tablet or capsule daily or the 400 mg tablet may be split and given as one half tablet every 12 hours. For the treatment of uncomplicated cervical/urethral gonococcal infections, a single oral dose of 400 mg is recommended. The capsule and tablet may be administered without regard to food.

In the treatment of infections due to Streptococcus pyogenes, a therapeutic dosage of cefixime should be administered for at least 10 days.

Pediatric Patients (6 months or older)

The recommended dose is 8 mg/kg/day of the suspension. This may be administered as a single daily dose or may be given in two divided doses, as 4 mg/kg every 12 hours.

Note: A suggested dose has been determined for each pediatric weight range. Refer to Table 1. Ensure all orders that specify a dose in milliliters include a concentration, because Suprax for oral suspension is available in three different concentrations (100 mg/5 mL, 200 mg/5 mL, and 500 mg/5 mL).

Table 1. Suggested doses for pediatric patients
*
The preferred concentrations of oral suspension to use are 100 mg/5 mL or 200 mg/5 mL for pediatric patients in these weight ranges.
PEDIATRIC DOSAGE CHART
Doses are suggested for each weight range and rounded for ease of administration

Suprax (cefiximefor Oral Suspension
Suprax (cefiximeChewable Tablet

100 mg/mL
200 mg/mL
500 mg/mL

Patient Weight
(kg)
Dose/Day 
(mg)
Dose/Day 
(mL)
Dose/Day 
(mL)
Dose/Day 
(mL)
Dose
5 to 7.5*
50
2.5
--
--
--
7.6 to 10*
80
4
2
--
--
10.1 to 12.5
100
5
2.5
1
1 tablet of 100 mg
12.6 to 20.5
150
7.5
4
1.5
1 tablet of 150 mg
20.6 to 28
200
10
5
2
1 tablet of 200 mg
28.1 to 33
250
12.5
6
2.5
1 tablet of 100 mg and 
1 tablet of 150 mg
33.1 to 40
300
15
7.5
3
2 tablets of 150 mg
40.1to 45
350
17.5
9
3.5
1 tablet of 150 mg and 
1 tablet of 200 mg
45.1 or greater
400
20
10
4
2 tablets of 200 mg

Children weighing more than 45 kg or older than 12 years should be treated with the recommended adult dose. Suprax (cefixime) Chewable Tablets must be chewed or crushed before swallowing.

Otitis media should be treated with the chewable tablets or suspension. Clinical trials of otitis media were conducted with the chewable tablets or suspension, and the chewable tablets or suspension results in higher peak blood levels than the tablet when administered at the same dose.

Therefore, the tablet or capsule should not be substituted for the chewable tablets or suspension in the treatment of otitis media. [See CLINICAL PHARMACOLOGY (12.3)]

In the treatment of infections due to Streptococcus pyogenes, a therapeutic dosage of cefixime should be administered for at least 10 days.

Renal Impairment

Suprax may be administered in the presence of impaired renal function. Normal dose and schedule may be employed in patients with creatinine clearances of 60 mL/min or greater. Refer to Table 2 for dose adjustments for adults with renal impairment. Neither hemodialysis nor peritoneal dialysis removes significant amounts of drug from the body.

Table 2. Doses for Adults with Renal Impairment
*
The preferred concentrations of oral suspension to use are 200 mg/5 mL or 500 mg/5 mL for patients with this renal dysfunction
Renal Dysfunction 
Suprax (cefiximefor Oral Suspension
Tablet
Chewable Tablet
Creatinine Clearance (mL/min)
100 mg/mL
200 mg/mL
500 mg/mL
400 mg
200 mg

Dose/Day (mL)
Dose/Day (mL)
Dose/Day (mL)
Dose/Day
Dose/Day
60 or greater
Normal dose
Normal dose
Normal dose
Normal dose
Normal dose
21 to 59*
OR renal hemodialysis*
13
6.5
2.6
Not Appropriate
Not Appropriate
20 or less 
OR continuous peritoneal dialysis 
8.6
4.4
1.8
0.5 tablet
1 tablet

Reconstitution Directions for Oral Suspension

Strength
Bottle Size
Reconstitution Directions
100 mg/5 mL and 
200 mg/5 mL
100 mL
To reconstitute, suspend with 68 mL water
Method: Tap the bottle several times to loosen powder contents prior to reconstitution. 
Add approximately half the total amount of water for reconstitution and shake well. 
Add the remainder of water and shake well.
100 mg/5 mL and 
200 mg/5 mL
75 mL
To reconstitute, suspend with 51 mL water
Method: Tap the bottle several times to loosen powder contents prior to reconstitution. 
Add approximately half the total amount of water for reconstitution and shake well. 
Add the remainder of water and shake well.
100 mg/5 mL and 
200 mg/5 mL
50 mL
To reconstitute, suspend with 34 mL water
Method: Tap the bottle several times to loosen powder contents prior to reconstitution. 
Add approximately half the total amount of water for reconstitution and shake well. 
Add the remainder of water and shake well.
200 mg/5 mL
37.5 mL
To reconstitute, suspend with 26 mL water
Method: Tap the bottle several times to loosen powder contents prior to reconstitution. 
Add approximately half the total amount of water for reconstitution and shake well. 
Add the remainder of water and shake well.
200 mg/5 mL
25 mL
To reconstitute, suspend with 17 mL water
Method: Tap the bottle several times to loosen powder contents prior to reconstitution. 
Add approximately half the total amount of water for reconstitution and shake well. 
Add the remainder of water and shake well.
500 mg/5 mL
20 mL
To reconstitute, suspend with 14 mL water
Method: Tap the bottle several times to loosen powder contents prior to reconstitution. 
Add approximately half the total amount of water for reconstitution and shake well. 
Add the remainder of water and shake well.
500 mg/5 mL
10 mL
To reconstitute, suspend with mL water
Method: Tap the bottle several times to loosen powder contents prior to reconstitution. 
Add approximately half the total amount of water for reconstitution and shake well. 
Add the remainder of water and shake well.

After reconstitution, the suspension may be kept for 14 days either at room temperature, or under refrigeration, without significant loss of potency. Keep tightly closed. Shake well before using. Discard unused portion after 14 days.

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