Fycompa Side Effects

Generic Name: perampanel

Note: This document contains side effect information about perampanel. Some of the dosage forms listed on this page may not apply to the brand name Fycompa.

Some side effects of Fycompa may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to perampanel: oral tablet

Along with its needed effects, perampanel (the active ingredient contained in Fycompa) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking perampanel:

More common
  • Aggression or anger
  • anxiety
  • clumsiness or unsteadiness
  • dry mouth
  • hyperventilation
  • irregular heartbeats
  • irritability
  • restlessness
  • shakiness and unsteady walk
  • shortness of breath
  • sleepiness or unusual drowsiness
  • trouble sleeping
  • unsteadiness, trembling, or other problems with muscle control or coordination
  • unusual tiredness or weakness
Less common
  • Abnormal or decreased touch sensation
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
Incidence not known
  • Changes in behavior
  • depression
  • thoughts of killing oneself

Some side effects of perampanel may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Dizziness or lightheadedness
  • feeling of constant movement of self or surroundings
  • headache
  • nausea
  • sensation of spinning
Less common
  • Back pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blurred vision
  • body aches or pain
  • bone pain
  • changes in speech patterns
  • chills
  • confusion
  • cough
  • decreased urine output
  • difficulty having a bowel movement (stool)
  • difficulty with breathing
  • difficulty with moving
  • double vision
  • ear congestion
  • fast or irregular heartbeat
  • fever
  • increased thirst
  • lack or loss of strength
  • loss of voice
  • muscle pain or cramps
  • muscle stiffness
  • nasal congestion
  • nausea or vomiting
  • pain in the arms or legs
  • pain in the joints
  • runny nose
  • slurred speech
  • sneezing
  • sore throat
  • trouble with speaking
  • trouble remembering
  • unusual weight gain or loss
  • unusually deep sleep
Incidence not known
  • Unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

For Healthcare Professionals

Applies to perampanel: oral tablet


Common (1% to 10%): Nausea (up to 8%), vomiting (up to 4%), constipation (up to 3%)


Common (1% to 10%): Weight gain (up to 4%), peripheral edema (up to 2%), hyponatremia (up to 2%)


Common (1% to 10%): Back pain (up to 5%), myalgia (up to 3%), pain in extremity (up to 3%), arthralgia (up to 2%), musculoskeletal pain (up to 2%)

Nervous system

Very common (10% or more): Dizziness (up to 43%), somnolence (up to 18%), headache (up to 13%), fatigue (up to 12%)

Common (1% to 10%): Ataxia (up to 8%), vertigo (up to 5%), gait disturbance (up to 4%), dysarthria (up to 4%), balance disorder (up to 3%), hypoesthesia (up to 3%), hypersomnia (up to 3%), asthenia (up to 2%), abnormal coordination (up to 2%), memory impairment (up to 2%), paresthesia (up to 2%)


Common (1% to 10%): Blurred vision (up to 4%), diplopia (up to 3%)


Common (1% to 10%): Falls (up to 10%), head injury (up to 3%), contusion (up to 2%), limb injury (up to 2%), skin laceration (up to 2 %)


Common (1% to 10%): Irritability (up to 12%), anxiety (up to 4%), aggression (up to 3%), anger (up to 3%), confusional state (up to 2%), euphoric state (up to 2%), mood altered (up to 2%)


Common (1% to 10%): Upper respiratory tract infection (up to 4%), cough (up to 4%), oropharyngeal pain (up to 2%)

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