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Estazolam Side Effects

Medically reviewed by Drugs.com. Last updated on Jul 26, 2023.

Applies to estazolam: oral tablet.

Warning

Oral route (Tablet)

Warning: Risks From Concomitant Use With Opioids; Abuse, Misuse, and Addiction; and Dependence and Withdrawal ReactionsConcomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death.Reserve concomitant prescribing of these drugs in patients for whom alternative treatment options are inadequate. Limit dosages and durations to the minimum required. Follow patients for signs and symptoms of respiratory depression and sedation.The use of benzodiazepines, including estazolam, exposes users to risks of abuse, misuse, and addiction, which can lead to overdose or death. Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes. Before prescribing estazolam and throughout treatment, assess each patient's risk for abuse, misuse, and addiction.The continued use of benzodiazepines, including estazolam, may lead to clinically significant physical dependence. The risks of dependence and withdrawal increase with longer treatment duration and higher daily dose. Abrupt discontinuation or rapid dosage reduction of estazolam after continued use may precipitate acute withdrawal reactions, which can be life-threatening. To reduce the risk of withdrawal reactions, use a gradual taper to discontinue estazolam or reduce the dosage.

Serious side effects of Estazolam

Along with its needed effects, estazolam may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking estazolam:

More common

Less common

Rare

Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking estazolam:

Symptoms of overdose

Other side effects of Estazolam

Some side effects of estazolam may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

Rare

Incidence not known

For Healthcare Professionals

Applies to estazolam: oral tablet.

General

The most commonly reported side effects were somnolence, hypokinesia, dizziness, and abnormal coordination.[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Allergic reaction[Ref]

Psychiatric

Very common (10% or more): Somnolence (42%)

Common (1% to 10%): Anxiety, depression, abnormal dream, abnormal thinking

Uncommon (0.1% to 1%): Agitation, apathy, emotional lability, euphoria, hostility, sleep disorder

Rare (less than 0.1%): Hallucinations[Ref]

Nervous system

Very common (10% or more): Headache (16%)

Common (1% to 10%): Hypokinesia, nervousness, dizziness, abnormal coordination, hangover, confusion

Uncommon (0.1% to 1%): Amnesia, paresthesia, seizure, stupor, twitch

Rare (less than 0.1%): Ataxia, circumoral paresthesia, decreased reflexes, neuritis, nystagmus, tremor

Frequency not reported: Minor changes in EEG patterns[Ref]

Hepatic

Rare (less than 0.1%): Increased SGOT[Ref]

Other

Very common (10% or more): Asthenia (11%)

Common (1% to 10%): Malaise, body pain

Uncommon (0.1% to 1%): Chills, fever, ear pain, perverse taste, tinnitus

Rare (less than 0.1%): Edema, decreased hearing[Ref]

Respiratory

Common (1% to 10%): Cold symptoms, pharyngitis

Uncommon (0.1% to 1%): Asthma, cough, dyspnea, rhinitis, sinusitis

Rare (less than 0.1%): Epistaxis, hyperventilation, laryngitis[Ref]

Gastrointestinal

Common (1% to 10%): Constipation, dry mouth, nausea, dyspepsia

Uncommon (0.1% to 1%): Decreased appetite, flatulence, gastritis, increased appetite, vomiting

Rare (less than 0.1%): Enterocolitis, melena, ulceration of the mouth[Ref]

Cardiovascular

Uncommon (0.1% to 1%): Flushing, palpitation

Rare (less than 0.1%): Arrhythmia, syncope[Ref]

Dermatologic

Uncommon (0.1% to 1%): Rash, sweating, urticaria

Rare (less than 0.1%): Acne, dry skin

Postmarketing reports: Stevens-Johnson syndrome, photosensitivity[Ref]

Endocrine

Rare (less than 0.1%): Thyroid nodule[Ref]

Genitourinary

Uncommon (0.1% to 1%): Frequent urination, menstrual cramps, urinary hesitancy, urinary urgency, vaginal discharge/itching

Rare (less than 0.1%): Swollen breast, decreased libido, hematuria, nocturia, oliguria, penile discharge, urinary incontinence[Ref]

Hematologic

Rare (less than 0.1%): Leukopenia, purpura, swollen lymph nodes

Postmarketing reports: Agranulocytosis[Ref]

Metabolic

Uncommon (0.1% to 1%): Thirst

Rare (less than 0.1%): Weight gain, weight loss[Ref]

Musculoskeletal

Common (1% to 10%): Lower extremity pain, back pain, stiffness

Uncommon (0.1% to 1%): Neck pain, upper extremity pain, arthritis, muscle spasm, myalgia

Rare (less than 0.1%): Jaw pain, arthralgia[Ref]

Ocular

Uncommon (0.1% to 1%): Abnormal vision, eye irritation, eye pain, eye swelling, photophobia

Rare (less than 0.1%): Diplopia, scotomata[Ref]

References

1. Product Information. Prosom (estazolam). Abbott Pharmaceutical. 2022.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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