BuSpar Side Effects

Generic Name: buspirone

Note: This page contains information about the side effects of buspirone. Some of the dosage forms included on this document may not apply to the brand name BuSpar.

Not all side effects for BuSpar may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to buspirone: oral tablet

Along with its needed effects, buspirone (the active ingredient contained in BuSpar) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking buspirone:

  • Chest pain
  • confusion
  • fast or pounding heartbeat
  • fever
  • incoordination
  • mental depression
  • muscle weakness
  • numbness, tingling, pain, or weakness in the hands or feet
  • skin rash or hives
  • sore throat
  • stiffness of the arms or legs
  • uncontrolled movements of the body

Get emergency help immediately if any of the following symptoms of overdose occur while taking buspirone:

Symptoms of overdose
  • Dizziness or lightheadedness especially when getting up from a sitting or lying position suddenly
  • drowsiness (severe)
  • loss of consciousness
  • nausea or vomiting
  • stomach upset
  • very small pupils of the eyes

Some side effects of buspirone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Restlessness, nervousness, or unusual excitement
Less common or rare
  • Blurred vision
  • clamminess or sweating
  • decreased concentration
  • diarrhea
  • drowsiness
  • dryness of the mouth
  • muscle pain, spasms, cramps, or stiffness
  • ringing in the ears
  • trouble with sleeping, nightmares, or vivid dreams
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to buspirone: compounding powder, oral tablet

Nervous system

There is currently no evidence for withdrawal, dependence or rebound anxiety after discontinuation of buspirone (the active ingredient contained in BuSpar)

Nervous system side effects have occurred and include dizziness, drowsiness and headache in about 10% of patients. Movement disorders such as myoclonus, oral dyskinesia, dystonia, and akathisia have been reported rarely. Extrapyramidal side effects, cogwheel rigidity, ataxia, emotional lability, serotonin syndrome, recall difficulty, parkinsonism, restlessness, and restless leg syndrome have been reported in postmarketing experience.


Gastrointestinal side effects including nausea have occurred in up to 11% of patients. Constipation, diarrhea and vomiting have also been reported.


Psychiatric side effects including mania, hypomania, vivid dreams, delirium, panic attack, and psychosis have been reported rarely. Dysphoria has been reported with long-term administration.


Genitourinary side effects such as priapism and urinary retention have been reported rarely.


Cardiovascular side effects following acute administration of buspirone (the active ingredient contained in BuSpar) have included transient, non-pathologic changes in blood pressure in male psychiatric patients. Effects on blood pressure (either increases or decreases) appear to be associated with the diagnosis.


Endocrine side effects have included elevations in plasma prolactin and cortisol.


An increase in appetite in some patients has been reported.

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