The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.
Cymbalta (duloxetine) for Depression: Tried it with the highest hopes for depression but it was awful. I am also on Ritalin for ADHD. I thought things were improving after the initial fist few weeks but pretty much in bed for a week whenever my dose was increased. So 30mg then 60mg then 90mg. I was quite suicidal at times and for the first time in a year I stayed home instead of going to work because I couldn't face people. I hid in my cocoon and fought bitterly with my partner while my parenting skills for our two year old daughter became more lax.
Review by OCD/Anxiety/Depression (taken for 1 to 2 years):
Cymbalta (duloxetine) for Anxiety: Cymbalta worked somewhat on my obsessive compulsive disorder, anxiety and depression better than other medicines. However, I felt like I couldn't do much. I had zero energy even though I took my dose (60mgs) at night. It became too tiring to even make myself something to eat. I did not want to go anywhere or do anything because I didn't have the energy.
At higher doses (90 mgs), I had stomach upset and pains if I did not take my dose with food. I would also have diarrhea/loose stools at the higher dose.
Sexual side effects were decreased interest and desire in sex. Could be attributed to just not having the energy to enjoy it.
It did help with my OCD and lowered my anxiety but did not help my depression.
Cymbalta (duloxetine) for Fibromyalgia: Took Cymbalta for close to a year for Fibro symptoms. For the first couple months it seemed to be helping, and then it stopped. I had worsening sleep difficulty, violent mood swings, and a variety of other side effects. Even with all the Fibro symptoms, I feel better off the med than I ever felt on it. It was also expensive.
Cymbalta (duloxetine) for Fibromyalgia: I found Cymbalta to be a miracle for me. Within a week of taking it most of my aches and pains disappeared and even my massage therapist stated she noticed a big difference. The problem was the side effects of sexual dysfunction and dry mouth. I added Wellbutrin and love that medication as it greatly improved my mood, but still did not help with the sexual dysfunction. I am now on Lamotrigine and Wellbutrin but the pains in my joints worsened unbelievably, intolerable really. I think I will be dropping the Lamotrigine and going back to the Cymbalta, and just put up with the side effects.
Cymbalta (duloxetine) for Depression: I was on cymbalta 60mg for 18 months. I've been on many different antidepressants throughout the years. My issue is not when you take it but when you go off. Please do not take this medicine. I've gone through hell the last 12 days getting this drug out of my system. Google cymbalta withdrawal or cymbalta discontinuation syndrome to learn more.
Cymbalta (duloxetine) for Generalized Anxiety Disorder: After having done fine w/alprazolam and citalopram for years, and wanting to slightly up my alprazolam for my GAD, Doc suggested I try cymbalta. I had a *horrible* experience with this drug (have never before experienced such bad side effects). I can't recall the dosage, but it was a sample, so I don't believe it was anything too high. First day I took it, I felt absolutely wiped out, like all the energy had been sucked from my body. I could barely make it to the bed to lay down. A few hours later the muscles in my jaw began spasm-ing involuntarily, I could feel them tightening and clamping my teeth together, then slightly relaxing. I didn't take the next pill, and it took a day for side effects to go away. I'll never take it again.
Cymbalta (duloxetine) for Chronic Pain: My rheumatologist had me on a very high dosage, so much that I had to pay for two seperate scripts at the pharmacy. I guess so many people do have a positive response to this med, my doctor thought increasing the med mg would result in symptom improvement, however that wasn't the case. I hated (that's a strong word for me) Cymbalta. I was told I acted like another person while on it and not in a good way. Even though I strictly followed my pharmacist and doctors directions when tapering off if this med, I still had severe withdrawal during and after reducing the mg. I even called the doctor and pharmacy because I was so concerned; I all but went to the emergency room in the beginning stages since I had never had withdrawal symptoms before.
13 users found this comment helpful.
Cymbalta (duloxetine) for Generalized Anxiety Disorder: I have been on Cymbalta for 7months and it has changed my life. I have Ocd, GAD and severe anxiety over health and I havent felt like myself in 4 years until cymbalta. I do get night sweats BADDDDD but its something I have got used too. I take 60mg a day and I never want to get off it. I am a 26 yr old healthy mum and anxiety now doesnt rule my life... I do! :-)
14 users found this comment helpful.
Cymbalta (duloxetine) for Depression: I have been taking different medicines for depression for the last 20 years. I have tried almost everything and Wellbutrin is the only thing that has even helped me. I have noticed only a very minor improvement but it is better than no improvement. I was advised to take Cymbalta with it. Even with my insurance, it still costs me $50 a month! I tried it for 3 months with no noticeable change. I can't afford to waste money on something that may or may not work. I figured for that much money, this drug should be very good. At least the Wellbutrin only costs me $10 a month and I do get some noticeable help from it.
Cymbalta (duloxetine) for Fibromyalgia: During my mid 40's, I began experiencing excruciating neck pain. I had cervical fusion for a ruptured cervical disk. After the surgery, I have had extreme chronic fatigue, bone pain, overall body pain, and paralysis of one vocal cord. I tried numerous pain medications which had absolutely no effect on my pain. Ultimately, the combination of medications that helped were a low dosage of methadone, Prozac, and Provigil (for narcolepsy). Recently my doctor changed by Prozac to Cymbalta. My pain is now almost
gone! (I am still taking methadone, but maybe it will no longer be necessary. (I changed to Nuvigil for extreme daytime sleepiness.) No side effects from Cymbalta except for slight nausea during the first week of use.
10 users found this comment helpful.
Review by Anonymous (taken for 6 months to 1 year):
Cymbalta (duloxetine) for Depression: I don't feel like this made too much of a difference and was prescribed to replace Zoloft which I believe was better but made me gain a lot of weight. Getting off of Cymbalta was very hard, although I followed my doctors instructions and decreased very gradually, by the end I had to start taking motion sickness pills due to the dizziness and nausea I experienced from the withdrawals. I also experienced headaches and felt like my eyes would cross every time I took a step. Getting onto it was super easy, I went from 60mg-120mg pretty quickly, and I lowered it from 120-90-60-30 over the course of about 2 months and still dealt with these withdrawal effects.
14 users found this comment helpful.
Cymbalta (duloxetine) for Anxiety: Cymbalta saved my sanity. I was under incredible work pressure and stress for three solid months (new job covering for one coworker on maternity leave another coworker having a sudden heart attack and Crohn's flare up. Me running the office for three months, even though I'd just been hired). I had a doctor's appointment and broke down on the table. He prescribed Celexa first, which gave me severe panic attacks. Then he switched me to Cymbalta, and I was back to normal within days.
The downside: It is extremely hard to stop taking it. I was intended to take it only for the short term, until things calmed down at work. Two years later, I'm still on it because going off was WEIRD. Numbness, tingling, weird sensory inputs, distraction.
18 users found this comment helpful.
Cymbalta (duloxetine) for Anxiety: I have been on Cymbalta for almost 5 years after a very difficult 4 years of PND/PSTD. Other medications got me to a point of about 50 percent improvement. This was far from ideal/adequate. Cymbalta worked for me like no other antidepressant. My anxiety reduced to the point where I can function at a pretty high level. I still have bouts of anxiety and occasional dark moods but they pass and even now are fewer and further between. I have tried to come off of it a few times but at 30mg the cogs begin to turn faster and I can feel my anxiety levels significantly increasing. I am concerned that my emotions are a bit blunted and like someone else said, I cannot cry, which I miss. I used to like a good, therapeutic cry. I also have no sex drive.
18 users found this comment helpful.
Cymbalta (duloxetine) for Depression: I love Cymbalta! I take it with 150mg of Wellbutrin XL. I am on 30mg at this time and in another week my Dr. wants me to up it to 60mg. I finally feel happy and have lots of energy. Combined with the Wellbutrin I have not gained any weight. Life is finally good again.
24 users found this comment helpful.
Cymbalta (duloxetine) for Anxiety: Have been on this medication for 4 yrs for Anxiety Disorder & Fibromyalgia. Cymbalta has definitely helped with both conditions. Without it, I'd be in an almost constant state of Anxiety & the Fibromyalgia flare-ups would be much worse. (Found this out when I reduced the dose from 60 mgs a day to 30mgs every other day, after hitting the expensive Medicare "donut hole" last year. That reduction also caused severe depression within a month and I've never been diagnosed with depression!). My side effects include some gastrointestinal problems & 30 lb. weight gain, despite daily exercise/diet. (All SSRI's cause weight gain for me). Hate the extra weight gain, but it's better than having Anxiety/Fibromyalgia pain.
Cymbalta (duloxetine) for Fibromyalgia: I am on Lyrica 150 mg a day, but it started to lose it's effectiveness after about 5 months. I can't afford to see the doctor or get more Lyrica. I tried Cymbalta for my PMDD and hoped that it might help my pain too. My pain was almost completely gone after about 2 days of use! However, I started getting sores on my tongue, emotional numbness, and had zero libido. I stopped using it after about 7 days, and the pain came back worse than ever (I believe I had been overdoing it those few days). I seriously considered putting up with the side effects just to get some pain relief, but I'm trying bupropion XL first.
11 users found this comment helpful.
Review by Mustangfire (taken for less than 1 month):
Cymbalta (duloxetine) for Fibromyalgia: I recently starting taking Cymbalta for my chronic back (several herniated discs), Costocondritis (chest inflamation), and other related pains classified as Fibromyalgia and Chronic lower back pain. The medication works. It has nearly removed my chest pain and lower back pains by 90% and only a few lingering pains still exist and only in spurts. I've only been on the 60mg dosage for a few weeks, so it may get better. As a side effect, my PE is gone. I never told a doc about it and it has been killing me for a decade. I've tried everything else, none helped. I looked online with a search of Cymbalta and PE and there are sources to confirm it works.
12 users found this comment helpful.
Cymbalta (duloxetine) for Depression: I cried everyday for three months due to uncontrollable pain from rheumatoid arthritis. I was also suffering from severe depression as a result. The first time I took Cymbalta,, 30 mg, I noticed I no longer felt defeated and felt for the first time since being diagnosed with rheumatoid arthritis that the pain was at times manageable. It helped give me hope. It's been almost three months since I started Cymbalta and it is still working well. I'm super thankful my doctor recommended it.
17 users found this comment helpful.
Cymbalta (duloxetine) for Fibromyalgia: I was on 60mg of Cymbalta for a year or more. Did not want to be on antidepressants all my life so I weaned off it 2 months ago. My fibromyalgia pains have returned with a vengeance, more than before. I am going back to Cymbalta as I want to have some quality of life. I feel debilitated at the moment. Have been taking this tablet in the morning but after reading the reviews on this forum I will change to night.
15 users found this comment helpful.
Review by JanetM416 (taken for less than 1 month):
Cymbalta (duloxetine) for Depression: I am on 30mg twice daily for depression and fibromyalgia. I have been extremely fatigued! I am also having episodes of doing things and not remembering and also passed out on the floor, but have no recollection of anything. All I want to do is sleep and if not for having a toddler at home and three children that I have to get off to school and one to work, I would probably just stay in bed sleeping all day and night. I'm hoping that this side effect wears off soon because otherwise they are helping a lot with my mood and depression. I was on Wellbutrin and it wasn't working, I had extreme episodes of crying and anger issues.
10 users found this comment helpful.
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