Azilsartan medoxomil / chlorthalidone Side Effects

Not all side effects for azilsartan medoxomil / chlorthalidone may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to azilsartan medoxomil / chlorthalidone: oral tablet

Along with its needed effects, azilsartan medoxomil / chlorthalidone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking azilsartan medoxomil / chlorthalidone:

Less common
  • Blurred vision
  • confusion
  • convulsions
  • decreased urine
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • fainting
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • shortness of breath
  • sweating
  • unusual tiredness or weakness
Incidence not known
  • Ankle, knee, or great toe joint pain
  • joint stiffness or swelling
  • lower back, side, or stomach pain
  • swelling of the feet or lower legs

Some side effects of azilsartan medoxomil / chlorthalidone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Dizziness
  • Cough
  • diarrhea
  • lack or loss of strength
  • muscle spasm
Incidence not known
  • Headache
  • loss of appetite
  • rash
  • stomach cramps

For Healthcare Professionals

Applies to azilsartan medoxomil / chlorthalidone: oral tablet


Cardiovascular side effects have included hypotension (1.7%).


Dermatologic side effects have included rash.


Endocrine side effects have included increased uric acid and increased cholesterol.


Gastrointestinal side effects have included vomiting, diarrhea, and GI upset.


Hematologic side effects have included azotemia, increased serum creatinine, and increased blood urea nitrogen (BUN).


Musculoskeletal side effects have included asthenia and muscle spasm.

Nervous system

Nervous system side effects have included dizziness (8.9%), postural dizziness, fatigue (2%), headache, and syncope (0.3%).


Respiratory side effects have included cough.

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