(mi noe SYE kleen)
- Minocycline Hydrochloride
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Minocin: 50 mg, 75 mg, 100 mg [contains brilliant blue fcf (fd&c blue #1), fd&c yellow #10 (quinoline yellow)]
Generic: 50 mg, 75 mg, 100 mg
Minocin: 50 mg [DSC], 100 mg [DSC] [contains brilliant blue fcf (fd&c blue #1), disodium edta, fd&c yellow #10 (quinoline yellow), sodium benzoate]
Solution Reconstituted, Intravenous:
Minocin: 100 mg (1 ea)
Dynacin: 50 mg [DSC], 75 mg [DSC], 100 mg [DSC]
Generic: 50 mg, 75 mg, 100 mg
Tablet Extended Release 24 Hour, Oral:
Solodyn: 55 mg [contains fd&c red #40]
Solodyn: 65 mg [contains brilliant blue fcf (fd&c blue #1), fd&c blue #2 (indigotine), fd&c yellow #10 (quinoline yellow)]
Solodyn: 80 mg [contains fd&c blue #2 (indigotine), fd&c red #40, fd&c yellow #6 (sunset yellow)]
Solodyn: 105 mg [contains brilliant blue fcf (fd&c blue #1)]
Solodyn: 115 mg [contains brilliant blue fcf (fd&c blue #1), fd&c blue #2 (indigotine), fd&c yellow #10 (quinoline yellow)]
Generic: 45 mg, 90 mg, 135 mg
Brand Names: U.S.
- Dynacin [DSC]
- Antibiotic, Tetracycline Derivative
Inhibits bacterial protein synthesis by binding with the 30S and possibly the 50S ribosomal subunit(s) of susceptible bacteria; cell wall synthesis is not affected
Rheumatoid arthritis: The mechanism of action of minocycline in rheumatoid arthritis is not completely understood. It is thought to have antimicrobial, anti-inflammatory, immunomodulatory, and chondroprotective effects. More specifically, it is thought to be a potent inhibitor of metalloproteinases, which are active in rheumatoid arthritis joint destruction.
Oral: Well absorbed
Widely distributed to most body fluids, bile, and tissues; poor CNS penetration; deposits in fat for extended periods; Vd: 0.14 to 0.7 L/kg (Zhanel 2004)
Hepatic to inactive metabolites
Urine (5% to 12% excreted unchanged) (Brogden 1975; Zhanel 2004); feces (20% to 34%) (Brogden 1975)
Time to Peak
Capsule, pellet filled: 1 to 4 hours; Tablet: 1 to 3 hours; Extended release tablet: 3.5 to 4 hours
IV: 15 to 23 hours; 11 to 16 hours (hepatic impairment); 18 to 69 hours (renal impairment); Oral: 16 hours (range: 11 to 17 hours)
55% to 96% (Zhanel 2004)
Use: Labeled Indications
Acute intestinal amebiasis: Adjunctive therapy to amebicides in the treatment of acute intestinal amebiasis
Oral (immediate release) and IV: Adjunctive therapy for the treatment of severe acne
Oral (extended-release): Treatment of only inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients 12 years and older
Actinomycosis: Treatment of actinomycosis caused by Actinomyces israelii when penicillin is contraindicated
Anthrax: Treatment of anthrax caused by Bacillus anthracis when penicillin is contraindicated
Asymptomatic carriers of Neisseria meningitides: Oral (immediate-release): To eliminate the meningococci from the nasopharynx of asymptomatic carriers of N. meningitidis
Campylobacter: Treatment of infections caused by Campylobacter fetus
Cholera: Treatment of cholera caused by Vibrio cholerae
Clostridium: Treatment of infections caused by Clostridium spp when penicillin is contraindicated
Gram-negative infections: Treatment of infections caused by susceptible Acinetobacter spp, Escherichia coli, Enterobacter aerogenes, Shigella spp
Listeriosis: Treatment of listeriosis due to Listeria monocytogenes when penicillin is contraindicated
Meningitis: Treatment of meningitis due to Neisseria meningitidis
Ophthalmic infections: Treatment of inclusion conjunctivitis or trachoma caused by Chlamydia trachomatis
Relapsing fever: Treatment of relapsing fever caused by Borrelia recurrentis
Respiratory tract infections: Treatment of respiratory tract infections caused by Haemophilus influenzae, Klebsiella spp, or Mycoplasma pneumonia. For the treatment of upper respiratory tract infections caused by Streptococcus pneumoniae.
Rickettsial infections: Treatment of Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by Rickettsiae
Sexually transmitted infections: Treatment of lymphogranuloma venereum caused by C. trachomatis; nongonococcal urethritis, endocervical, or rectal infections in adults caused by Ureaplasma urealyticum or C. trachomatis; donovanosis (granuloma inguinale) caused by Klebsiella granulomatis; syphilis caused by Treponema pallidum subspecies pallidum, when penicillin is contraindicated
Skin and skin structure infections: Treatment of skin and skin structure infections caused by Staphylococcus aureus
Limitations of use: Not considered a first line agent for any staphylococcal infection
Urinary tract infections: Treatment of urinary tract infections caused by Klebsiella species
Vincent infection: Treatment of Vincent infection caused by Fusobacterium fusiforme when penicillin is contraindicated
Yaws: Treatment of yaws caused by T. pallidum subspecies pertenue when penicillin is contraindicated
Zoonotic infections: Treatment of psittacosis (ornithosis) due to Chlamydia psittaci; plague due to Yersinia pestis; tularemia due to Francisella tularensis; brucellosis due to Brucella spp (in conjunction with streptomycin); bartonellosis due to Bartonella bacilliformis
Rheumatoid arthritis (patients with low disease activity of short duration); nocardiosis; alternative treatment for community-acquired MRSA infection; chronic oral antimicrobial suppression of prosthetic joint infection
Hypersensitivity to minocycline, other tetracyclines, or any component of the formulation
Documentation of allergenic cross-reactivity for tetracyclines is limited. However, because of similarities in chemical structure and/or pharmacologic actions, the possibility of cross-sensitivity cannot be ruled out with certainty.
Usual dosage range:
IV: Initial: 200 mg for 1 dose; Maintenance: 100 mg every 12 hours (maximum: 400 mg daily)
Oral: Initial: 200 mg for 1 dose; Maintenance: 100 mg every 12 hours; more frequent dosing intervals may be used (100 to 200 mg initially, followed by 50 mg 4 times daily)
Acne: Oral: Capsule or immediate-release tablet: 50 to 100 mg twice daily
Acne (inflammatory, non-nodular, moderate to severe): Note: Therapy should be continued for 12 weeks. Safety of use beyond 12 weeks has not been established.
Extended-release capsule (Ximino): Oral: 1 mg/kg (rounded to the nearest capsule) once daily
Extended-release tablet (Solodyn): Oral:
45 to 49 kg: 45 mg once daily
50 to 59 kg: 55 mg once daily
60 to 71 kg: 65 mg once daily
72 to 84 kg: 80 mg once daily
85 to 96 kg: 90 mg once daily
97 to 110 kg: 105 mg once daily
111 to 125 kg: 115 mg once daily
126 to 136 kg: 135 mg once daily
Cellulitis (purulent) due to community-acquired MRSA (off-label use): Oral: Initial: 200 mg; Maintenance: 100 mg twice daily for 5-10 days (Liu, 2011)
Chlamydial or Ureaplasma urealyticum infection, uncomplicated: Oral, IV: Urethral, endocervical, or rectal: 100 mg every 12 hours for at least 7 days
Gonococcal infection, uncomplicated (males): Oral, IV:
Without urethritis or anorectal infection: Initial: 200 mg for 1 dose; Maintenance: 100 mg every 12 hours for at least 4 days (cultures 2 to 3 days post-therapy)
Urethritis: 100 mg every 12 hours for 5 days
Meningococcal carrier state (manufacturer's labeling): Oral: 100 mg every 12 hours for 5 days. Note: CDC recommendations do not mention use of minocycline for eradicating nasopharyngeal carriage of meningococcal
Mycobacterium marinum: Oral: 100 mg every 12 hours for 6 to 8 weeks
Nocardiosis, cutaneous (non-CNS) (off-label use): Oral: 100 to 200 mg every 12 hours
Prosthetic joint infection:
Staphylococci (oxacillin-sensitive or –resistant) oral phase treatment (after completion of pathogen-specific IV therapy) following 1-stage exchange:
Total ankle, elbow, hip, or shoulder arthroplasty: 100 mg twice daily for 3 months; Note: Must be used in combination with rifampin (Osmon, 2013)
Total knee arthroplasty: 100 mg twice daily for 6 months; Note: Must be used in combination with rifampin (Osmon, 2013)
Chronic oral antimicrobial suppression (off-label use): Oral:
Propionibacterium spp (alternative to penicillin or amoxicillin): 100 mg twice daily (Osmon, 2013)
Staphylococci (oxacillin-resistant): 100 mg twice daily (Osmon, 2013)
Rheumatoid arthritis (off-label use): Oral: 100 mg twice daily (O’Dell, 2001)
Syphilis: Oral, IV: Initial: 200 mg for 1 dose; Maintenance: 100 mg every 12 hours for 10 to 15 days
Refer to adult dosing.
Usual dosage range: Children >8 years and Adolescents: Oral, IV: Initial: 4 mg/kg/dose for 1 dose; Maintenance: 2 mg/kg/dose every 12 hours (maximum: 400 mg daily)
Acne (inflammatory, non-nodular, moderate to severe: Children ≥12 years and Adolescents: Oral: Refer to adult dosing.
Cellulitis (purulent) infection due to community-acquired MRSA (off-label use): Oral: Children >8 years: Initial: 4 mg/kg (maximum: 200 mg); Maintenance: 2 mg/kg/dose (maximum: 100 mg) every 12 hours for 5 to 10 days (Liu, 2011)
Dosing: Renal Impairment
Use with caution. Consider decreasing dose or increasing dosing interval (extended release).
CrCl ≥80 mL/minute: No dosage adjustment necessary
CrCl <80 mL/minute: Do not exceed 200 mg daily
Dosing: Hepatic Impairment
There are no dosage adjustments provided in the manufacturer’s labeling; however, hepatotoxicity has been reported. Use with caution.
Injection: Reconstitute with 5 mL of sterile water for injection and immediately further dilute in 100 to 1,000 mL of NS, D5W, D5NS, or 250 mL to 1,000 mL of LR. Note: Preparation instructions are for the reformulated product (containing magnesium) available as of July 2015.
Note: IV administration instructions are for the reformulated product (containing magnesium) available as of July 2015. Refer to the following for additional information: http: / / links.mkt1283.com / servlet / MailView?ms=MjMwNTcwMzIS1&r=MTI2NjgzODE5NjE3S0&j=NjAxNDY4MzkzS0&mt=1&rt=0
IV: Infuse over 60 minutes; avoid rapid administration. The injectable route should be used only if the oral route is not feasible or adequate. Prolonged intravenous therapy may be associated with thrombophlebitis.
Oral: May be administered with or without food. Administer with adequate fluid to decrease the risk of esophageal irritation and ulceration. Swallow pellet-filled capsule and extended-release tablet or capsule whole; do not chew, crush, or split.
Stable in NS, D5W, D51/4NS, D51/2NS, D5NS, LR.
Incompatible with calcium-containing solutions (except LR)
Capsule (including pellet-filled), tablet: Store at 20°C to 25°C (68°F to 77°F); protect from heat. Protect from light and moisture.
Extended-release capsule: Store at 20°C to 25°C (68°F to 77°F); excursions are permitted to 15°C to 30°C (59°F to 86°F). Protect from light, moisture, and excessive heat.
Extended-release tablet: Store at 15°C to 30°C (59°F to 86°F); protect from heat. Protect from light and moisture.
Injection: Store intact vials at 20°C to 25°C (68°F to 77°F). Diluted solution is stable at room temperature for up to 4 hours or at 2°C to 8°C (36°F to 46°F) for up to 24 hours.
Antacids: May decrease the absorption of Tetracycline Derivatives. Consider therapy modification
Atazanavir: Minocycline may decrease the serum concentration of Atazanavir. Monitor therapy
BCG (Intravesical): Antibiotics may diminish the therapeutic effect of BCG (Intravesical). Avoid combination
BCG Vaccine (Immunization): Antibiotics may diminish the therapeutic effect of BCG Vaccine (Immunization). Monitor therapy
Bile Acid Sequestrants: May decrease the absorption of Tetracycline Derivatives. Consider therapy modification
Bismuth Subcitrate: May decrease the serum concentration of Tetracycline Derivatives. Management: Avoid administration of oral tetracyclines within 30 minutes of bismuth subcitrate administration. This is of questionable significance for at least some regimens intended to treat H. pylori infections. Consider therapy modification
Bismuth Subsalicylate: May decrease the serum concentration of Tetracycline Derivatives. Management: Consider dosing tetracyclines 2 hours before or 6 hours after bismuth. The need to separate doses during Helicobacter pylori eradication regimens is questionable. Consider therapy modification
Calcium Salts: May decrease the serum concentration of Tetracycline Derivatives. Management: If coadministration of oral calcium with oral tetracyclines can not be avoided, consider separating administration of each agent by several hours. Consider therapy modification
CNS Depressants: Minocycline may enhance the CNS depressant effect of CNS Depressants. Monitor therapy
Iron Salts: Tetracycline Derivatives may decrease the absorption of Iron Salts. Iron Salts may decrease the serum concentration of Tetracycline Derivatives. Exceptions: Ferric Carboxymaltose; Ferric Gluconate; Ferric Pyrophosphate Citrate; Ferumoxytol; Iron Dextran Complex; Iron Sucrose. Consider therapy modification
Lanthanum: May decrease the serum concentration of Tetracycline Derivatives. Management: Administer oral tetracycline antibiotics at least two hours before or after lanthanum. Consider therapy modification
Magnesium Dimecrotate: May interact via an unknown mechanism with Tetracycline Derivatives. Monitor therapy
Magnesium Salts: May decrease the absorption of Tetracycline Derivatives. Only applicable to oral preparations of each agent. Consider therapy modification
Mecamylamine: Tetracycline Derivatives may enhance the neuromuscular-blocking effect of Mecamylamine. Avoid combination
Mipomersen: Tetracycline Derivatives may enhance the hepatotoxic effect of Mipomersen. Monitor therapy
Multivitamins/Minerals (with ADEK, Folate, Iron): May decrease the serum concentration of Tetracycline Derivatives. Management: If coadministration of a polyvalent cation-containing multivitamin with oral tetracyclines can not be avoided, separate administration of each agent by several hours. Consider therapy modification
Multivitamins/Minerals (with AE, No Iron): May decrease the serum concentration of Tetracycline Derivatives. Management: If coadministration of a polyvalent cation-containing multivitamin with oral tetracyclines can not be avoided, separate administration of each agent by several hours. Consider therapy modification
Neuromuscular-Blocking Agents: Minocycline may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents. Monitor therapy
Penicillins: Tetracycline Derivatives may diminish the therapeutic effect of Penicillins. Consider therapy modification
Porfimer: Photosensitizing Agents may enhance the photosensitizing effect of Porfimer. Monitor therapy
Quinapril: May decrease the serum concentration of Tetracycline Derivatives. Management: Separate doses of quinapril and oral tetracycline derivatives by at least 2 hours in order to reduce the risk of interaction. Monitor for reduced efficacy of the tetracycline if these products are used concomitantly. Consider therapy modification
Retinoic Acid Derivatives: Tetracycline Derivatives may enhance the adverse/toxic effect of Retinoic Acid Derivatives. The development of pseudotumor cerebri is of particular concern. Exceptions: Adapalene; Bexarotene (Topical); Tretinoin (Topical). Avoid combination
Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate. Management: Consider using an alternative product for bowel cleansing prior to a colonoscopy in patients who have recently used or are concurrently using an antibiotic. Consider therapy modification
Strontium Ranelate: May decrease the serum concentration of Tetracycline Derivatives. Management: In order to minimize any potential impact of strontium ranelate on tetracycline antibiotic concentrations, it is recommended that strontium ranelate treatment be interrupted during tetracycline therapy. Avoid combination
Sucralfate: May decrease the absorption of Tetracycline Derivatives. Management: Administer the tetracycline derivative at least 2 hours prior to sucralfate in order to minimize the impact of this interaction. Consider therapy modification
Sucroferric Oxyhydroxide: May decrease the serum concentration of Tetracycline Derivatives. Management: Administer oral/enteral doxycycline at least 1 h before sucroferric oxyhydroxide. Specific dose separation guidelines for other tetracyclines are not presently available. No interaction is anticipated with parenteral administration of tetracyclines. Consider therapy modification
Typhoid Vaccine: Antibiotics may diminish the therapeutic effect of Typhoid Vaccine. Only the live attenuated Ty21a strain is affected. Management: Vaccination with live attenuated typhoid vaccine (Ty21a) should be avoided in patients being treated with systemic antibacterial agents. Use of this vaccine should be postponed until at least 3 days after cessation of antibacterial agents. Consider therapy modification
Verteporfin: Photosensitizing Agents may enhance the photosensitizing effect of Verteporfin. Monitor therapy
Vitamin K Antagonists (eg, warfarin): Tetracycline Derivatives may enhance the anticoagulant effect of Vitamin K Antagonists. Monitor therapy
Zinc Salts: May decrease the absorption of Tetracycline Derivatives. Only a concern when both products are administered orally. Management: Consider doxycycline as a noninteracting tetracycline derivative. Separate dose administration of oral tetracycline derivative and oral zinc salts by at least 2 hours to minimize interaction. Exceptions: Zinc Chloride. Consider therapy modification
May cause interference with fluorescence test for urinary catecholamines (false elevations)
1% to 10%:
Central nervous system: Dizziness (9%), fatigue (9%), malaise (4%), drowsiness (2%)
Dermatologic: Pruritus (5%), urticaria (2%)
Neuromuscular & skeletal: Arthralgia (1%)
Otic: Tinnitus (2%)
Postmarketing and/or case reports (Limited to important or life-threatening): Acute renal failure (reversible), autoimmune hepatitis, balanitis, bulging fontanel, Clostridium dificile associated diarrhea, DRESS syndrome, enterocolitis, eosinophilia, erythema multiforme, exacerbation of systemic lupus erythematosus, exfoliative dermatitis, fixed drug eruption, glossitis, hearing loss, hemolytic anemia, hepatic failure, hepatitis, hepatotoxicity (idiosyncratic) (Chalasani 2014), hypersensitivity, IgA vasculitis, lupus-like syndrome, malignant neoplasm of thyroid, microscopic thyroid discoloration (brown-black), mucous membrane pigmentation, myocarditis, pancreatitis, pericarditis, pneumonitis, polyarthralgia, pseudomembranous colitis, pseudotumor cerebri, pulmonary infiltrates (with eosinophilia), serum sickness, skin photosensitivity, skin pigmentation, Stevens-Johnson syndrome, thrombocytopenia, thyroid dysfunction, tooth discoloration, vasculitis
Concerns related to adverse effects:
• Autoimmune syndromes: Lupus-like, hepatitis, and vasculitis autoimmune syndromes (including serum sickness [eg fever, arthralgia, and malaise]) have been reported; discontinue if symptoms occur and assess liver function tests, ANA, and CBC.
• Benign intracranial hypertension (eg, pseudotumor cerebri [PTC]): Intracranial hypertension (headache, blurred vision, diplopia, vision loss, and/or papilledema) has been associated with use. Women of childbearing age who are overweight or have a history of intracranial hypertension are at greater risk. Concomitant use of isotretinoin (known to cause PTC) and minocycline should be avoided. Intracranial hypertension typically resolves after discontinuation of treatment; however, permanent visual loss is possible. If visual symptoms develop during treatment, prompt ophthalmologic evaluation is warranted. Intracranial pressure can remain elevated for weeks after drug discontinuation; monitor patients until they stabilize.
• CNS effects: Lightheadedness, dizziness, and vertigo may occur; patients must be cautioned about performing tasks which require mental alertness (eg, operating machinery or driving). Symptoms usually disappear with continued therapy and when the drug is discontinued.
• Hepatotoxicity: Serious liver injury, including irreversible drug induced hepatitis and fulminant hepatic failure (sometimes fatal) have been reported with use for acne treatment.
• Hyperpigmentation: Hyperpigmentation may occur in nails, bone, skin (including scar and injury sites), eyes, sclerae, thyroid, oral cavity, visceral tissue, and heart valves; skin and oral hyperpigmentation are independent of dose or administration duration.
• Hypersensitivity: Anaphylaxis has been reported; discontinue drug immediately and institute supportive measures.
• Increased BUN: May be associated with increases in BUN secondary to antianabolic effects; use caution in patients with renal impairment as this may lead to azotemia, hyperphosphatemia, acidosis, and possibly to drug accumulation and potential hepatotoxicity.
• Photosensitivity: May cause photosensitivity; discontinue if skin erythema occurs. Use skin protection and avoid prolonged exposure to sunlight; avoid use of use tanning equipment or UVA/B treatment.
• Skin rash: Rash, erythema multiforme, Stevens Johnson syndrome or eosinophilia, fever, and organ failure (Drug Rash with Eosinophilia and Systemic Symptoms [DRESS] syndrome), may occur; onset of symptoms may be delayed up to several weeks; fatal in up to 10% of cases; discontinue treatment immediately if DRESS syndrome is suspected.
• Superinfection: Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea (CDAD) and pseudomembranous colitis; CDAD has been observed >2 months postantibiotic treatment.
• Hepatic impairment: Hepatotoxicity has been reported; use with caution in patients with hepatic impairment or in conjunction with other hepatotoxic drugs.
• Renal impairment: Use with caution in patients with renal impairment (CrCl <80 mL/minute).
Concurrent drug therapy issues:
• Drug-drug interactions: Potentially significant interactions may exist, requiring dose or frequency adjustment, additional monitoring, and/or selection of alternative therapy. Consult drug interactions database for more detailed information.
• Pediatric: May cause tissue hyperpigmentation, tooth enamel hypoplasia, or permanent tooth discoloration; more common with long-term use, but observed with repeated, short courses; use of tetracyclines should be avoided during tooth development (infancy and children ≤8 years of age) unless other drugs are not likely to be effective or are contraindicated.
• Pregnancy: Do not use during pregnancy. In addition to affecting tooth development, tetracycline use has been associated with retardation of skeletal development and reduced bone growth.
• Rheumatoid arthritis (off-label/investigational): Contraindicated in pregnancy and breast-feeding; Child-Pugh Class C and acute hepatitis B and C (Saag KG, 2008).
Dosage form specific issues:
• Magnesium content: Parenteral (IV) formulation contains magnesium; monitor serum magnesium in patients with renal impairment and signs of magnesium intoxication (eg, flushing, sweating, hypotension, depressed reflexes, flaccid paralysis, hypothermia, circulatory collapse, cardiac and CNS depression leading to respiratory paralysis). Also use with caution and closely monitor patients with heart block or myocardial damage.
LFTs, BUN, renal function with long-term treatment, serum magnesium in patients with renal impairment; if symptomatic for autoimmune disorder, include ANA, CBC; ophthalmologic evaluation if visual disturbances occur. If used for syphilis, obtain follow up serologic tests 3 months after treatment.
Pregnancy Risk Factor
Tetracyclines cross the placenta and accumulate in developing teeth and long tubular bones. Rare spontaneous reports of congenital anomalies, including limb reduction, have been reported following maternal minocycline use. Due to limited information, a causal association cannot be established. Tetracyclines may discolor fetal teeth following maternal use during pregnancy; the specific teeth involved and the portion of the tooth affected depends on the timing and duration of exposure relative to tooth calcification. As a class, tetracyclines are generally considered second-line antibiotics in pregnant women and their use should be avoided (Mylonas, 2011). Minocycline should not be used for the treatment of acne in pregnant women, or in males or females attempting to conceive a child.
• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
• Patient may experience diarrhea, dizziness, fatigue, nausea, lack of appetite, or injection site irritation. Have patient report immediately to prescriber signs of hepatic impairment, signs of pancreatitis, vision changes, blurred vision, urinary retention, oliguria, chills, pharyngitis, hearing impairment, arthralgia, joint edema, myalgia, headache, tinnitus, dyspnea, dysphagia, hematuria, angina, arrhythmia, edema, skin discoloration, eye discoloration, nail discoloration, tooth discoloration, gingival changes, ecchymosis, hemorrhaging, significant asthenia, stomatitis, rectal irritation, genital irritation, blindness, vaginitis, diplopia, blindness, signs of hepatic impairment, signs of Stevens Johnson/Syndrome/toxic epidermal necrolysis, swollen lymph nodes, or signs of pseudomembranous colitis (rare) (HCAHPS).
• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.
Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating, and advising patients.
More about minocycline
- Minocycline Hydrochloride (AHFS Monograph)
- Minocycline Hydrochloride eent (AHFS Monograph)
- Minocycline (FDA)
- Minocycline Capsules (FDA)
- Minocycline Extended Release Tablets (FDA)
- Minocycline Tablets (FDA)