Minocycline

Pronunciation

Generic Name: minocycline (mye no SYE kleen)
Brand Names: Dynacin, Minocin, Minocin PAC, Myrac, Solodyn, Vectrin

What is minocycline?

Minocycline is a tetracycline antibiotic that fights bacteria in the body.

Minocycline is used to treat many different bacterial infections, such as urinary tract infections, respiratory infections, skin infections, severe acne, gonorrhea, tick fever, chlamydia, and others.

Minocycline may also be used for purposes not listed in this medication guide.

Important information

Do not use this medicine if you are pregnant. It could harm the unborn baby or cause permanent tooth discoloration later in life.

Minocycline can make birth control pills less effective. Ask your doctor about using a non hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using minocycline.

Minocycline passes into breast milk and may affect bone and tooth development in a nursing baby. Do not take this medication without telling your doctor if you are breast-feeding a baby. Children should not take this medication. Minocycline can cause permanent yellowing or graying of the teeth in children younger than 8 years old.

Slideshow: Flashback: FDA Drug Approvals 2013

Avoid exposure to sunlight or tanning beds. Minocycline can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Do not take iron supplements, multivitamins, calcium supplements, antacids, or laxatives within 2 hours before or after taking minocycline. These products can make minocycline less effective.

Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Throw away any unused medicine after the expiration date on the label has passed. Using expired minocycline can cause damage to your kidneys.

Before taking this medicine

You should not take this medicine if you are allergic to minocycline or to other tetracycline antibiotics such as demeclocycline (Declomycin), doxycycline (Adoxa, Doryx, Oracea, Vibramycin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).

To make sure you can safely take minocycline, tell your doctor if you have any of these other conditions:

  • liver disease;

  • kidney disease;

  • asthma or sulfite allergy; or

  • if you are also using a penicillin antibiotic such as amoxicillin (Amoxil, Augmentin, Dispermox, Moxatag), ampicillin (Principen, Unasyn), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill), or penicillin (Bicillin L-A, PC Pen VK, Pfizerpen).

If you are using minocycline to treat gonorrhea, your doctor may test you to make sure you do not also have syphilis, another sexually transmitted disease.

FDA pregnancy category D. Do not use minocycline if you are pregnant. It could harm the unborn baby or cause permanent tooth discoloration later in life. Tell your doctor right away if you become pregnant during treatment.

See also: Pregnancy and breastfeeding warnings (in more detail)

Minocycline can make birth control pills less effective. Ask your doctor about using a non hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using minocycline.

Minocycline passes into breast milk and may affect bone and tooth development in a nursing baby. You should not breast-feed while you are taking minocycline. Children should not use this medicine. Minocycline can cause permanent yellowing or graying of the teeth in children younger than 8 years old.

How should I take minocycline?

Take minocycline exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take this medicine with a full glass (8 ounces) of water.

Most brands of minocycline may be taken with or without food.

Take Minocin (pellet-filled capsules) on an empty stomach, at least 1 hour before or 2 hours after a meal. Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time.

Take minocycline for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Minocycline will not treat a viral infection such as the common cold or flu.

To be sure this medicine is not causing harmful effects, your blood will need to be tested often. Your kidney, liver, or thyroid function may also need to be tested. Visit your doctor regularly.

If you need surgery, tell the surgeon ahead of time that you are using minocycline. You may need to stop using the medicine for a short time.

Minocycline can cause false results with certain urine tests. Tell any doctor who treats you that you are using this medication.

Store minocycline at room temperature away from moisture, heat, and light. Throw away any unused minocycline when it expires or when it is no longer needed. Do not take any minocycline after the expiration date printed on the label. Using expired minocycline can cause damage to your kidneys.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, and diarrhea.

What should I avoid?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking minocycline and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Avoid exposure to sunlight or tanning beds. Minocycline can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Do not take iron supplements, multivitamins, calcium supplements, antacids, or laxatives within 2 hours before or after taking minocycline.

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Minocycline side effects

Get emergency medical help if you have any of these signs of an allergic reaction to minocycline: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

  • stomach cramps, diarrhea that is watery or bloody;

  • flu symptoms, sores in your mouth and throat;

  • pale or yellowed skin, weakness, dark colored urine, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

  • fever, skin rash, bruising, severe tingling or numbness, muscle weakness,

  • upper stomach pain, loss of appetite, jaundice (yellowing of the skin or eyes);

  • chest pain, irregular heart rhythm, cough, wheezing, feeling short of breath;

  • confusion, vomiting, swelling, weight gain, urinating less than usual or not at all;

  • headache or pain behind your eyes, ringing in your ears, vision problems;

  • joint pain or swelling with fever, swollen glands, muscle aches, general ill feeling, unusual thoughts or behavior, and/or seizure (convulsions); or

  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious minocycline side effects may include:

  • dizziness, tired feeling, spinning sensation;

  • joint or muscle pain;

  • discoloration of you skin or nails;

  • mild nausea, mild diarrhea, upset stomach;

  • mild skin rash or itching;

  • swollen tongue, discoloration of your gums; or

  • vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Minocycline dosing information

Usual Adult Minocycline Dose for Acne:

Immediate-release formulations:
Initial dose: 50 to 100 mg orally twice a day for 3 to 6 weeks or until improvement occurs
Maintenance dose: 50 to 100 mg orally once a day

Extended-release tablets:
45 to 49 kg: 45 mg orally once a day
50 to 59 kg: 55 mg orally once a day
60 to 71 kg: 65 mg orally once a day
72 to 84 kg: 80 mg orally once a day
85 to 96 kg: 90 mg orally once a day
97 to 110 kg: 105 mg orally once a day
111 to 125 kg: 115 mg orally once a day
126 to 136 kg: 135 mg orally once a day

Duration: 12 weeks

Usual Adult Minocycline Dose for Actinomycosis:

100 mg orally or IV every 12 hours

Duration: Initial parenteral therapy for 2 to 6 weeks, followed by oral therapy for a total duration of 6 to 12 months

Clinical response should be monitored by CT or MRI.

Usual Adult Minocycline Dose for Bacterial Infection:

Oral: 200 mg initially followed by 100 mg orally every 12 hours; alternatively, 100 to 200 mg initially followed by 50 mg orally 4 times a day has been used

IV: 200 mg initially followed by 100 mg IV every 12 hours (maximum dose: 400 mg/24 hours)

Usual Adult Minocycline Dose for Meningitis -- Meningococcal:

Elimination of Neisseria meningitidis carrier state: 100 mg orally every 12 hours for 5 days

Rifampin, ciprofloxacin, or ceftriaxone are considered first-line agents.

Usual Adult Minocycline Dose for Skin or Soft Tissue Infection:

Mycobacterium marinum: 100 mg orally or IV every 12 hours for at least 3 months

Vibrio vulnificus: 100 mg IV or orally every 12 hours plus cefotaxime 2 g IV every 8 hours or ceftazidime 1 to 2 g IV every 8 hours

Usual Adult Minocycline Dose for Skin and Structure Infection:

Mycobacterium marinum: 100 mg orally or IV every 12 hours for at least 3 months

Vibrio vulnificus: 100 mg IV or orally every 12 hours plus cefotaxime 2 g IV every 8 hours or ceftazidime 1 to 2 g IV every 8 hours

Usual Pediatric Minocycline Dose for Acne:

12 years or older:
Extended-release tablets:
45 to 49 kg: 45 mg orally once a day
50 to 59 kg: 55 mg orally once a day
60 to 71 kg: 65 mg orally once a day
72 to 84 kg: 80 mg orally once a day
85 to 96 kg: 90 mg orally once a day
97 to 110 kg: 105 mg orally once a day
111 to 125 kg: 115 mg orally once a day
126 to 136 kg: 135 mg orally once a day

Duration: 12 weeks

Usual Pediatric Minocycline Dose for Bacterial Infection:

9 years or older: 4 mg/kg orally or IV initially followed by 2 mg/kg every 12 hours

The usual adult dosage should not be exceeded.

What other drugs will affect minocycline?

Tell your doctor about all other medicines you use, especially:

  • other antibiotics;

  • acetaminophen (Tylenol);

  • isotretinoin (Accutane, Amnesteem, Claravis, Sotret);

  • methotrexate (Rheumatrex, Trexall);

  • antifungal medicine such as itraconazole (Sporanox), ketoconazole (Extina, Ketozole, Nizoral, Xolegal), miconazole (Oravig), or voriconazole (Vfend);

  • a blood thinner such as warfarin (Coumadin, Jantoven);

  • cholesterol medications such as niacin (Advicor, Niaspan, Niacor, Simcor, Slo Niacin, and others), atorvastatin (Lipitor, Caduet), fluvastatin (Lescol), lovastatin (Mevacor, Altoprev, Advicor), pravastatin (Pravachol), rosuvastatin (Crestor), or simvastatin (Zocor, Simcor, Vytorin);

  • heart or blood pressure medicine such as benazepril (Lotensin), enalapril (Vasotec), lisinopril (Prinivil, Zestril), quinapril (Accupril), ramipril (Altace), and others;

  • migraine headache medicine such as ergotamine (Ergomar, Cafergot, Migergot), dihydroergotamine (D.H.E. 45, Migranal), or methylergonovine (Methergine); or

  • an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Cataflam, Voltaren), indomethacin (Indocin), meloxicam (Mobic), and others.

This list is not complete and other drugs may interact with minocycline. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about minocycline.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use minocycline only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.

Copyright 1996-2014 Cerner Multum, Inc. Version: 12.01. Revision Date: 3/14/2011 11:46:54 PM.

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