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oxacillin

Generic Name: oxacillin (ox a SIL in)
Brand Name: Bactocill, Oxacillin Sodium ADD-Vantage

What is oxacillin?

Oxacillin is an antibiotic in the penicillin group of drugs. It fights bacteria in your body.

Oxacillin is used to treat many different types of infections caused by bacteria, such as a staphylococcal (also called "staph") infection.

Oxacillin may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about oxacillin?

Do not use this medication if you are allergic to oxacillin or to any other penicillin antibiotic, such as amoxicillin (Amoxil), ampicillin (Omnipen, Principen), carbenicillin (Geocillin), dicloxacillin (Dycill, Dynapen), penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids), and others.

Before using oxacillin, tell your doctor if you are allergic to cephalosporins such as Ceclor, Ceftin, Duricef, Keflex, and others, or if you have asthma, liver disease, kidney disease, or a history of any type of allergy.

Slideshow: Flashback: FDA Drug Approvals 2013

Oxacillin can make birth control pills less effective, which may result in pregnancy. Before taking oxacillin, tell your doctor if you use birth control pills.

Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Oxacillin will not treat a viral infection such as the common cold or flu.

Do not share this medication with another person, even if they have the same symptoms you have.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

What should I discuss with my healthcare provider before taking oxacillin?

Do not use this medication if you are allergic to oxacillin or to any other penicillin antibiotic, such as:

  • amoxicillin (Amoxil, Amoxicot, Biomox, Dispermox, Trimox);

  • ampicillin (Omnipen, Principen);

  • carbenicillin (Geocillin);

  • dicloxacillin (Dycill, Dynapen);

  • penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids, and others).

Before using oxacillin, tell your doctor if you are allergic to any drugs (especially cephalosporins such as Ceclor, Ceftin, Duricef, Keflex, and others), or if you have:

  • asthma;

  • liver disease;

  • kidney disease;

  • a bleeding or blood clotting disorder;

  • a history of diarrhea caused by taking antibiotics; or

  • a history of any type of allergy.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take oxacillin.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Oxacillin can make birth control pills less effective, which may result in pregnancy. Before taking oxacillin, tell your doctor if you use birth control pills.

Oxacillin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take oxacillin?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take the medicine with a full glass of water.

Oxacillin should be taken on an empty stomach, at least 1 hour before or 2 hours after eating a meal.

To be sure this medication is helping your condition, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled visits to your doctor.

Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Oxacillin will not treat a viral infection such as the common cold or flu.

Do not share oxacillin with another person, even if they have the same symptoms you have.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using oxacillin.

Store oxacillin at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include confusion, behavior changes, a severe skin rash, urinating less than usual, or seizure (black-out or convulsions).

What should I avoid while taking oxacillin?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Oxacillin side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;

  • diarrhea that is watery or bloody;

  • fever, chills, body aches, flu symptoms;

  • easy bruising or bleeding, unusual weakness;

  • urinating less than usual or not at all;

  • severe skin rash, itching, or peeling;

  • agitation, confusion, unusual thoughts or behavior; or

  • seizure (black-out or convulsions).

Less serious side effects may include:

  • nausea, vomiting, stomach pain;

  • vaginal itching or discharge;

  • headache;

  • swollen, black, or "hairy" tongue; or

  • thrush (white patches or inside your mouth or throat).

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Oxacillin dosing information

Usual Adult Dose for Bacterial Infection:

Manufacturer Recommendations:
Mild to moderate infections: 250 to 500 mg IV or IM every 4 to 6 hours
Severe infections: 1 g IV or IM every 4 to 6 hours

Duration of therapy: Therapy should continue for at least 14 days in severe staphylococcal infections. Therapy should continue for at least 48 hours after patient is afebrile, asymptomatic, and has negative cultures. Endocarditis and osteomyelitis may require a longer duration of therapy.

Approved indication: Treatment of infections caused by susceptible penicillinase-producing staphylococci

Usual Adult Dose for Endocarditis:

Manufacturer Recommendations: See Usual Adult Dose (Bacterial Infection)

American Heart Association (AHA) recommendations:
Native valve endocarditis due to staphylococci: 2 g IV every 4 hours or 3 g IV every 6 hours (total 12 g/day)

Duration of therapy:
Complicated right-sided infective endocarditis (IE), left-sided IE: 6 weeks
Uncomplicated right-sided IE: 2 weeks

Comments:
-With optional addition of gentamicin 3 mg/kg/day IV or IM in 2 or 3 equally divided doses for 3 to 5 days.
-Refer to current published guidelines for detailed recommendations.

Prosthetic valve endocarditis due to staphylococci: 2 g IV every 4 hours (total 12 g/day)
Duration of therapy: 6 weeks or longer

Comments:
-Plus rifampin 300 mg IV or orally every 8 hours for 6 weeks or longer.
-Plus gentamicin 3 mg/kg/day IV or IM in 2 or 3 equally divided doses for 2 weeks.
-Refer to current published guidelines for detailed recommendations.

Usual Adult Dose for Joint Infection:

Manufacturer Recommendations: See Usual Adult Dose (Bacterial Infection)

Some experts recommend: 2 g IV or IM every 4 to 6 hours
Duration of therapy: 3 to 4 weeks, depending on the nature and severity of the infection. Longer therapy, for 6 weeks or longer, may be required for prosthetic joint infections.
Comments: A third-generation cephalosporin, ciprofloxacin, and/or rifampin should be added, depending on the results of the Gram stain.

Usual Adult Dose for Meningitis:

Manufacturer Recommendations: See Usual Adult Dose (Bacterial Infection)

Some experts recommend: 2 g IV or IM every 4 hours
Duration of therapy: 14 days, depending on the nature and severity of the infection.

Usual Adult Dose for Osteomyelitis:

Manufacturer Recommendations: See Usual Adult Dose (Bacterial Infection)

Some experts recommend: 1.5 to 2 g IV every 4 hours
Duration of therapy: In general, treatment of acute or chronic osteomyelitis should continue for 3 to 8 weeks followed by treatment with an oral penicillinase-resistant penicillin. Parenteral penicillinase-resistant therapy for 5 to 28 days followed by oral penicillinase-resistant penicillin for 3 to 6 weeks has also been effective for acute osteomyelitis.

Usual Adult Dose for Pneumonia:

Manufacturer Recommendations: See Usual Adult Dose (Bacterial Infection)

Some experts recommend: 2 g IV or IM every 4 hours
Duration of therapy: Therapy should continue for 7 to 10 days if pneumococcus pneumonia is suspected and up to 21 days if other organisms are responsible.

Usual Adult Dose for Septicemia:

Manufacturer Recommendations: See Usual Adult Dose (Bacterial Infection)

Some experts recommend: 2 g IV or IM every 4 to 6 hours
Duration of therapy: 14 days, depending on the nature and severity of the infection.

Usual Adult Dose for Sinusitis:

Manufacturer Recommendations: See Usual Adult Dose (Bacterial Infection)

Some experts recommend: 1 to 1.5 g IV or IM every 4 to 6 hours
Duration of therapy: 10 to 14 days, depending on the nature and severity of the infection.

Usual Adult Dose for Skin or Soft Tissue Infection:

Manufacturer Recommendations: See Usual Adult Dose (Bacterial Infection)

Some experts recommend: 1 to 1.5 g IV or IM every 4 to 6 hours
Duration of therapy: 7 days, or for 3 days after acute inflammation resolves, depending on the nature and severity of the infection.

Usual Pediatric Dose for Bacterial Infection:

Manufacturer Recommendations:
Premature and neonates: 25 mg/kg/day IV or IM

Infants and children weighing less than 40 kg:
Mild to moderate infections: 12.5 mg/kg IV or IM every 6 hours
Severe infections: 100 mg/kg/day IV or IM in equally divided doses every 4 to 6 hours

Children weighing 40 kg or more:
Mild to moderate infections: 250 to 500 mg IV or IM every 4 to 6 hours
Severe infections: 1 g IV or IM every 4 to 6 hours

Duration of therapy: Therapy should continue for at least 14 days in severe staphylococcal infections. Therapy should continue for at least 48 hours after patient is afebrile, asymptomatic, and has negative cultures. Endocarditis and osteomyelitis may require a longer duration of therapy.

Approved indication: Treatment of infections caused by susceptible penicillinase-producing staphylococci

American Academy of Pediatrics Recommendations:
Less than 1 week:
Less than 1200 g: 25 mg/kg IV or IM every 12 hours
1200 to 2000 g: 25 to 50 mg/kg IV or IM every 12 hours
Greater than 2000 g: 25 to 50 mg/kg IV or IM every 8 hours

1 to 4 weeks:
Less than 1200 g: 25 mg/kg IV or IM every 12 hours
1200 to 2000 g: 25 to 50 mg/kg IV or IM every 8 hours
Greater than 2000 g: 25 to 50 mg/kg IV or IM every 6 hours

1 month or older:
Mild to moderate infections: 100 to 150 mg/kg/day IV or IM in 4 divided doses
Severe infections: 150 to 200 mg/kg/day IV or IM in 4 divided doses

Maximum dose: 12 g/day

Usual Pediatric Dose for Endocarditis:

Manufacturer Recommendations: See Usual Pediatric Dose (Bacterial Infection)

AHA recommendations:
Native valve endocarditis due to staphylococci: 200 mg/kg/day IV in 4 to 6 equally divided doses
Maximum dose: 12 g/day

Duration of therapy:
Complicated right-sided IE, left-sided IE: 6 weeks
Uncomplicated right-sided IE: 2 weeks

Comments:
-With optional addition of gentamicin 1 mg/kg IV or IM every 8 hours for 3 to 5 days.
-Refer to current published guidelines for detailed recommendations.

Prosthetic valve endocarditis due to staphylococci: 200 mg/kg/day IV in 4 to 6 equally divided doses
Maximum dose: 12 g/day
Duration of therapy: 6 weeks or longer

Comments:
-Plus rifampin 20 mg/kg/day IV or orally in 3 equally divided doses for 6 weeks or longer.
-Plus gentamicin 1 mg/kg IV or IM every 8 hours for 2 weeks.
-Refer to current published guidelines for detailed recommendations.

What other drugs will affect oxacillin?

Before taking oxacillin, tell your doctor if you are using any of the following drugs:

  • methotrexate (Rheumatrex, Trexall); or

  • probenecid (Benemid).

This list is not complete and there may be other drugs that can interact with oxacillin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about oxacillin.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 4.03. Revision Date: 2010-12-15, 5:01:39 PM.

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