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Oxacillin

Generic Name: oxacillin (OX-a-SIL-in)
Brand Name: Generic only. No brands available.

Oxacillin is used for:

Treating infections caused by certain bacteria.

Oxacillin is a penicillin antibiotic. It works by blocking the growth of the bacteria's cell wall, resulting in the death of the bacteria.

Do NOT use oxacillin if:

  • you are allergic to any ingredient in oxacillin or any other penicillin antibiotic (eg, amoxicillin)
  • you are taking a tetracycline antibiotic (eg, doxycycline)

Contact your doctor or health care provider right away if any of these apply to you.

Before using oxacillin:

Some medical conditions may interact with oxacillin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to a cephalosporin antibiotic (eg, cephalexin) or other beta-lactam antibiotic (eg, imipenem)
  • if you are allergic to corn or corn products
  • if you have asthma, kidney problems, bleeding or clotting problems, or abnormal blood electrolyte levels, or if you are dehydrated
  • if you are on a low-salt diet

Some MEDICINES MAY INTERACT with oxacillin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Tetracyclines (eg, doxycycline) because they may decrease oxacillin's effectiveness
  • Anticoagulants (eg, warfarin) because their effectiveness may be decreased or the risk of their side effects may be increased by oxacillin
  • Heparin or methotrexate because the risk of their side effects may be increased by oxacillin
  • Aminoglycosides (eg, gentamicin) or oral contraceptives (birth control pills) because their effectiveness may be decreased by oxacillin

This may not be a complete list of all interactions that may occur. Ask your health care provider if oxacillin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use oxacillin:

Use oxacillin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Oxacillin is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using oxacillin at home, a health care provider will teach you how to use it. Be sure you understand how to use oxacillin. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use oxacillin if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • To clear up your infection completely, use oxacillin for the full course of treatment. Keep using it even if you feel better in a few days.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of oxacillin, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use oxacillin.

Important safety information:

  • Oxacillin only works against bacteria; it does not treat viral infections (eg, the common cold).
  • Be sure to use oxacillin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Long-term or repeated use of oxacillin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
  • Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea, (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
  • Oxacillin may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Tell your doctor or dentist that you take oxacillin before you receive any medical or dental care, emergency care, or surgery.
  • Hormonal birth control (eg, birth control pills) may not work as well while you are using oxacillin. To prevent pregnancy, use an extra form of birth control (eg, condoms).
  • Lab tests, including kidney or liver function tests, complete blood cell counts, or blood electrolyte levels, may be performed while you use oxacillin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use oxacillin with caution in the ELDERLY; they may be more sensitive to its effects.
  • Oxacillin should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • Use oxacillin with extreme caution in CHILDREN younger than 10 years old who have diarrhea or an infection of the stomach or bowel.
  • PREGNANCY and BREAST-FEEDING: If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using oxacillin while you are pregnant. Oxacillin is found in breast milk. If you are or will be breast-feeding while you use oxacillin, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of oxacillin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild diarrhea, nausea, or vomiting; swelling or redness at the injection site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black tongue; blood in the urine; bloody stools; chest pain; dark urine; fever, chills, or sore throat; joint or muscle pain; mouth irritation; red, swollen, or blistered skin; seizures; severe diarrhea; severe or persistent nausea or vomiting; severe stomach pain/cramps; swelling in the mouth; swollen joints; unusual bruising or bleeding; vaginal irritation or discharge; vein swelling or tenderness; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include agitation; confusion; hallucinations; seizures; severe excitability; tremor; unconsciousness.

Proper storage of oxacillin:

Oxacillin is usually handled and stored by a health care provider. If you are using oxacillin at home, store oxacillin as directed by your pharmacist or health care provider. Store away from heat, moisture, and light. Keep oxacillin out of the reach of children and away from pets.

General information:

  • If you have any questions about oxacillin, please talk with your doctor, pharmacist, or other health care provider.
  • Oxacillin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take oxacillin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about oxacillin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to oxacillin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using oxacillin.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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