Oxacillin Dosage

This dosage information may not include all the information needed to use Oxacillin safely and effectively. See additional information for Oxacillin.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Bacterial Infection

Manufacturer Recommendations:
Mild to moderate infections: 250 to 500 mg IV or IM every 4 to 6 hours
Severe infections: 1 g IV or IM every 4 to 6 hours

Duration of therapy: Therapy should continue for at least 14 days in severe staphylococcal infections. Therapy should continue for at least 48 hours after patient is afebrile, asymptomatic, and has negative cultures. Endocarditis and osteomyelitis may require a longer duration of therapy.

Approved indication: Treatment of infections caused by susceptible penicillinase-producing staphylococci

Usual Adult Dose for Endocarditis

Manufacturer Recommendations: See Usual Adult Dose (Bacterial Infection)

American Heart Association (AHA) recommendations:
Native valve endocarditis due to staphylococci: 2 g IV every 4 hours or 3 g IV every 6 hours (total 12 g/day)

Duration of therapy:
Complicated right-sided infective endocarditis (IE), left-sided IE: 6 weeks
Uncomplicated right-sided IE: 2 weeks

Comments:
-With optional addition of gentamicin 3 mg/kg/day IV or IM in 2 or 3 equally divided doses for 3 to 5 days.
-Refer to current published guidelines for detailed recommendations.

Prosthetic valve endocarditis due to staphylococci: 2 g IV every 4 hours (total 12 g/day)
Duration of therapy: 6 weeks or longer

Comments:
-Plus rifampin 300 mg IV or orally every 8 hours for 6 weeks or longer.
-Plus gentamicin 3 mg/kg/day IV or IM in 2 or 3 equally divided doses for 2 weeks.
-Refer to current published guidelines for detailed recommendations.

Usual Adult Dose for Joint Infection

Manufacturer Recommendations: See Usual Adult Dose (Bacterial Infection)

Some experts recommend: 2 g IV or IM every 4 to 6 hours
Duration of therapy: 3 to 4 weeks, depending on the nature and severity of the infection. Longer therapy, for 6 weeks or longer, may be required for prosthetic joint infections.
Comments: A third-generation cephalosporin, ciprofloxacin, and/or rifampin should be added, depending on the results of the Gram stain.

Usual Adult Dose for Meningitis

Manufacturer Recommendations: See Usual Adult Dose (Bacterial Infection)

Some experts recommend: 2 g IV or IM every 4 hours
Duration of therapy: 14 days, depending on the nature and severity of the infection.

Usual Adult Dose for Osteomyelitis

Manufacturer Recommendations: See Usual Adult Dose (Bacterial Infection)

Some experts recommend: 1.5 to 2 g IV every 4 hours
Duration of therapy: In general, treatment of acute or chronic osteomyelitis should continue for 3 to 8 weeks followed by treatment with an oral penicillinase-resistant penicillin. Parenteral penicillinase-resistant therapy for 5 to 28 days followed by oral penicillinase-resistant penicillin for 3 to 6 weeks has also been effective for acute osteomyelitis.

Usual Adult Dose for Pneumonia

Manufacturer Recommendations: See Usual Adult Dose (Bacterial Infection)

Some experts recommend: 2 g IV or IM every 4 hours
Duration of therapy: Therapy should continue for 7 to 10 days if pneumococcus pneumonia is suspected and up to 21 days if other organisms are responsible.

Usual Adult Dose for Septicemia

Manufacturer Recommendations: See Usual Adult Dose (Bacterial Infection)

Some experts recommend: 2 g IV or IM every 4 to 6 hours
Duration of therapy: 14 days, depending on the nature and severity of the infection.

Usual Adult Dose for Sinusitis

Manufacturer Recommendations: See Usual Adult Dose (Bacterial Infection)

Some experts recommend: 1 to 1.5 g IV or IM every 4 to 6 hours
Duration of therapy: 10 to 14 days, depending on the nature and severity of the infection.

Usual Adult Dose for Skin or Soft Tissue Infection

Manufacturer Recommendations: See Usual Adult Dose (Bacterial Infection)

Some experts recommend: 1 to 1.5 g IV or IM every 4 to 6 hours
Duration of therapy: 7 days, or for 3 days after acute inflammation resolves, depending on the nature and severity of the infection.

Usual Pediatric Dose for Bacterial Infection

Manufacturer Recommendations:
Premature and neonates: 25 mg/kg/day IV or IM

Infants and children weighing less than 40 kg:
Mild to moderate infections: 12.5 mg/kg IV or IM every 6 hours
Severe infections: 100 mg/kg/day IV or IM in equally divided doses every 4 to 6 hours

Children weighing 40 kg or more:
Mild to moderate infections: 250 to 500 mg IV or IM every 4 to 6 hours
Severe infections: 1 g IV or IM every 4 to 6 hours

Duration of therapy: Therapy should continue for at least 14 days in severe staphylococcal infections. Therapy should continue for at least 48 hours after patient is afebrile, asymptomatic, and has negative cultures. Endocarditis and osteomyelitis may require a longer duration of therapy.

Approved indication: Treatment of infections caused by susceptible penicillinase-producing staphylococci

American Academy of Pediatrics Recommendations:
Less than 1 week:
Less than 1200 g: 25 mg/kg IV or IM every 12 hours
1200 to 2000 g: 25 to 50 mg/kg IV or IM every 12 hours
Greater than 2000 g: 25 to 50 mg/kg IV or IM every 8 hours

1 to 4 weeks:
Less than 1200 g: 25 mg/kg IV or IM every 12 hours
1200 to 2000 g: 25 to 50 mg/kg IV or IM every 8 hours
Greater than 2000 g: 25 to 50 mg/kg IV or IM every 6 hours

1 month or older:
Mild to moderate infections: 100 to 150 mg/kg/day IV or IM in 4 divided doses
Severe infections: 150 to 200 mg/kg/day IV or IM in 4 divided doses

Maximum dose: 12 g/day

Usual Pediatric Dose for Endocarditis

Manufacturer Recommendations: See Usual Pediatric Dose (Bacterial Infection)

AHA recommendations:
Native valve endocarditis due to staphylococci: 200 mg/kg/day IV in 4 to 6 equally divided doses
Maximum dose: 12 g/day

Duration of therapy:
Complicated right-sided IE, left-sided IE: 6 weeks
Uncomplicated right-sided IE: 2 weeks

Comments:
-With optional addition of gentamicin 1 mg/kg IV or IM every 8 hours for 3 to 5 days.
-Refer to current published guidelines for detailed recommendations.

Prosthetic valve endocarditis due to staphylococci: 200 mg/kg/day IV in 4 to 6 equally divided doses
Maximum dose: 12 g/day
Duration of therapy: 6 weeks or longer

Comments:
-Plus rifampin 20 mg/kg/day IV or orally in 3 equally divided doses for 6 weeks or longer.
-Plus gentamicin 1 mg/kg IV or IM every 8 hours for 2 weeks.
-Refer to current published guidelines for detailed recommendations.

Renal Dose Adjustments

Dose adjustment(s) may be required; however, no specific guidelines have been suggested. Caution recommended.

Some experts recommend:
Adults with CrCl less than 10 mL/min: The dose used should be the lower range of the usual dose.

Liver Dose Adjustments

Data not available

Precautions

Consult WARNINGS section for dosing related precautions.

Dialysis

Data not available; minimally removed by dialysis

Other Comments

General:
-Bacteriologic studies recommended to verify causative organisms and susceptibility.
-Parenteral therapy should be used initially in severe infections. Oral therapy may be used as follow-up therapy as soon as the clinical condition warrants.

Monitoring:
-General: Clinical and laboratory signs of toxic or adverse effects (pediatric patients); blood cultures (prior to and at least weekly during therapy); blood levels (renally impaired patients).
-Hematologic: White blood cell and differential cell counts (prior to and at least weekly during therapy); hematopoietic function (during prolonged therapy).
-Hepatic: AST and ALT periodically (during therapy); hepatic function (during prolonged therapy).
-Renal: Periodic urinalysis, blood urea nitrogen, and creatinine (during therapy); renal function (geriatric patients; during prolonged therapy).

Severe allergies and anaphylaxis: Learn how epinephrine can save a life. Watch Video

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