Generic Name: amlodipine and benazepril (am LOE di peen and ben AY ze pril)
Brand Names: Lotrel
What is Lotrel?
Lotrel contains a combination of amlodipine and benazepril. Amlodipine is a calcium channel blocker. Amlodipine relaxes (widens) blood vessels and improves blood flow.
Benazepril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Benazepril also widens blood vessels and also prevents the body from retaining water.
Lotrel is used to treat high blood pressure (hypertension).
Lotrel may also be used for purposes not listed in this medication guide.
Do not use Lotrel if you are pregnant. Stop using and tell your doctor right away if you become pregnant. Lotrel can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control.
You should not use this medication if you are allergic to amlodipine (Norvasc) or benazepril (Lotensin), or if you have ever had angioedema (hives or severe swelling of deep skin tissues sometimes caused by allergic reaction).
Before you use Lotrel, tell your doctor about all your other medical conditions and allergies. Also make sure your doctor knows if you are pregnant or breast-feeding. In some cases, you may not be able to use Lotrel, or you may need a dose adjustment or special precautions.
Certain other drugs may interact with Lotrel or should not be used at the same time. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using.
Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking Lotrel, which can lead to severely low blood pressure or a serious electrolyte imbalance.
Before taking this medicine
You should not use Lotrel if:
you are allergic to amlodipine (Norvasc, Caduet, Exforge, Lotrel, Tekamlo, Tribenzor, Twynsta, Amturnide) or benazepril (Lotensin);
you have ever had angioedema (hives or severe swelling of deep skin tissues sometimes caused by allergic reaction); or
you are allergic to any other ACE inhibitor, such as captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik).
If you have diabetes or kidney disease, you may not be able to take Lotrel if you are also taking a blood pressure medication that contains aliskiren (Amturnide, Tekturna, Tekamlo, or Valturna).
To make sure Lotrel is safe for you, tell your doctor if you have:
kidney disease (or if you are on dialysis);
heart disease or congestive heart failure;
a connective tissue disease such as Marfan syndrome, Sjogren's syndrome, lupus, scleroderma, or rheumatoid arthritis;
if you are on a low-salt diet.
FDA pregnancy category D. Do not use if you are pregnant. Stop using and tell your doctor right away if you become pregnant. Lotrel can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control.
See also: Pregnancy and breastfeeding warnings (in more detail)
Amlodipine and benazepril can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using Lotrel.
How should I take Lotrel?
Take Lotrel exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Your doctor may occasionally change your dose to make sure you get the best results.
Lotrel can be taken with or without food. Take the medicine at the same time each day.
Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medication, which can lead to severely low blood pressure or a serious electrolyte imbalance.
Your blood pressure will need to be checked often. You may also need frequent blood tests at your doctor's office.
If you need surgery, tell the surgeon ahead of time that you are using Lotrel. You may need to stop using the medicine for a short time.
Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. If you are more than 12 hours late, skip the missed dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid?
This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Do not use salt substitutes or potassium supplements while taking Lotrel, unless your doctor has told you to.
Drinking alcohol can increase certain side effects of Lotrel.
Lotrel side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Lotrel: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American.
Some side effects of Lotrel may not occur until after you have been using the medication for several months.
Call your doctor at once if you have:
feeling like you might pass out;
nausea, upper stomach pain, itching, unusual weakness or tired feeling, jaundice (yellowing of the skin or eyes);
swelling in your hands or feet, rapid weight gain;
new or worsened chest pain;
fever, chills, sore throat, body aches, flu symptoms; or
high potassium (slow heart rate, weak pulse, muscle weakness, tingly feeling).
Other common Lotrel side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Lotrel?
Many drugs can interact with Lotrel. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with Lotrel, especially:
gold injections to treat arthritis;
a shot for bee-sting allergy;
a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others;
a potassium supplement such as K-Dur, Klor-Con;
salt substitutes that contain potassium; or
a diuretic (water pill).
This list is not complete and many other drugs can interact with Lotrel. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
Compare with other treatments for:
Where can I get more information?
- Your pharmacist can provide more information about Lotrel.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Lotrel only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2014 Cerner Multum, Inc. Version: 8.01. Revision Date: 2012-12-13, 2:45:57 PM.