Trazodone Disease Interactions
There are 5 disease interactions with trazodone:
Trazodone (Includes Trazodone) ↔ Cardiovascular Disease
Severe Potential Hazard, Moderate plausibility
Applies to: Cardiovascular Disease, Hyperthyroidism
Although less cardiotoxic than the tricyclic antidepressants, trazodone may be arrhythmogenic in some patients with cardiac disease. The use of trazodone has been associated with the occurrence of arrhythmias, including PVCs, ventricular couplets, ventricular tachycardia, atrial fibrillation, and heart block. Myocardial infarction has been reported. Trazodone should not be used during the acute recovery phase following myocardial infarction, and should be administered only with extreme caution in patients with hyperthyroidism and/or cardiovascular disease. Close monitoring of cardiovascular status, including ECG changes, is recommended at all dosages. Many of the newer antidepressants, including bupropion and the selective serotonin reuptake inhibitors (SSRIs), are considerably less or minimally cardiotoxic and may be appropriate alternatives.
Trazodone (Includes Trazodone) ↔ Hypotension
Severe Potential Hazard, High plausibility
Applies to: Cerebrovascular Insufficiency, Dehydration, Diarrhea, History - Cerebrovascular Disease, History - Myocardial Infarction, Hypotension, Ischemic Heart Disease, Vomiting
Trazodone has alpha-1 adrenergic blocking activity and may cause hypotension (including orthostatic hypotension) in approximately 5% of patients. Therapy with trazodone should be administered cautiously in patients with hypotension or conditions that could be exacerbated by hypotension, such as a history of myocardial infarction, angina, or ischemic stroke. Patients with dehydration (e.g., due to severe diarrhea or vomiting) may be predisposed to hypotension and should also be managed carefully during therapy with trazodone. Blood pressure should be monitored at regular intervals, particularly during dosage escalation or whenever dosage has been altered, and patients should be advised not to rise abruptly from a sitting or recumbent position.
Trazodone (Includes Trazodone) ↔ Renal/Liver Disease
Severe Potential Hazard, Moderate plausibility
Applies to: Liver Disease, Renal Dysfunction
Trazodone undergoes metabolism in the liver. The metabolites, at least one of which is pharmacologically active, are excreted by the kidney. There are no data available concerning the pharmacokinetic disposition of trazodone or its metabolites in patients with renal and/or liver disease. Therapy with trazodone should be administered cautiously in patients with significantly impaired renal or hepatic function. Dosage adjustments may be necessary.
Antidepressants (Includes Trazodone) ↔ Mania
Moderate Potential Hazard, Moderate plausibility
Applies to: Bipolar Disorder, Mania
All antidepressants may occasionally cause mania or hypomania, particularly in patients with bipolar disorder. Therapy with antidepressants should be administered cautiously in patients with a history of mania/hypomania.
Nefazodone/Trazodone (Includes Trazodone) ↔ Seizures
Moderate Potential Hazard, Low plausibility
Applies to: Seizures
The use of most antidepressants is associated with a risk of seizures. There have been only rare reports of convulsions, including grand mal seizures, following the administration of nefazodone or trazodone. Although a causal relationship has not been established, therapy with these agents should be administered cautiously in patients with a history of seizures.
You should also know about...
trazodone drug Interactions
There are 896 drug interactions with trazodone
trazodone alcohol/food Interactions
There is 1 alcohol/food interaction with trazodone
See also...
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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