Oxycodone

Pronunciation

Generic Name: oxycodone (OX-i-KOE-done)
Brand Name: Oxecta

Oxycodone is used for:

Treating acute or chronic moderate to severe pain. It may also be used for other conditions as determined by your doctor.

Oxycodone is a narcotic pain reliever. It works in the brain and nervous system to reduce pain.

Do NOT use oxycodone if:

  • you are allergic to any ingredient in oxycodone
  • you are taking sodium oxybate (GHB) or you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days
  • you have stomach or bowel blockage or a certain severe bowel motility problem (paralytic ileus)
  • you have severely slow or difficult breathing, high blood carbon dioxide levels (hypercarbia), or severe asthma, or you are having an asthma attack

Contact your doctor or health care provider right away if any of these apply to you.

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Before using oxycodone:

Some medical conditions may interact with oxycodone. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to any other narcotic pain medicines (eg, morphine, hydrocodone)
  • if you have a history of asthma, chronic obstructive pulmonary disease (COPD), or other lung or breathing problems
  • if you have a history of recent head injury, increased pressure in the brain, growths in the brain (eg, tumors), or seizures
  • if you have a history of heart problems, low blood pressure, liver or kidney problems, an underactive thyroid, adrenal gland problems (eg, Addison disease), stomach or bowel problems, gallbladder problems, inflammation of the pancreas (pancreatitis), a blockage of the bladder, an enlarged prostate, hypercarbia, low blood oxygen levels (hypoxia), curvature of the spine (scoliosis), or the blood disease porphyria
  • if you have a history of drug or alcohol abuse, mood or mental problems, or suicidal thoughts or behavior
  • if you have poor health or nutrition, low blood volume, dehydration, severe drowsiness, or stomach pain, or you are in alcohol or other substance withdrawal
  • if you are taking amiodarone, quinidine, or antidepressants

Some MEDICINES MAY INTERACT with oxycodone. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticholinergics (eg, scopolamine), benzodiazepines (eg, alprazolam), cimetidine, furazolidone, MAOIs (eg, phenelzine), muscle relaxers (eg, cyclobenzaprine), phenothiazines (eg, chlorpromazine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because the risk of side effects, such as severe drowsiness, slow or difficult breathing, confusion, severe constipation, trouble urinating, and seizures, may be increased
  • Azole antifungals (eg, ketoconazole), macrolide antibiotics (eg, erythromycin), or protease inhibitors (eg, ritonavir) because they may increase the risk of oxycodone's side effects
  • Buprenorphine, butorphanol, carbamazepine, nalbuphine, naltrexone, pentazocine, phenytoin, or rifampin because the effectiveness of oxycodone may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if oxycodone may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use oxycodone:

Use oxycodone as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take oxycodone by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Swallow oxycodone whole. Do not break, crush, dissolve, or chew before swallowing. Take each tablet with enough water to ensure complete swallowing immediately after being placed in the mouth.
  • Do not pre-soak, lick, or wet the tablet prior to placing it in the mouth.
  • Do not suddenly stop taking oxycodone if you have been receiving oxycodone for more than a few weeks. You may have an increased risk of side effects. If you need to stop oxycodone, your doctor will gradually lower your dose.
  • If oxycodone is no longer needed, dispose of it by flushing it down the toilet. You may also check with your pharmacist for other ways to dispose of oxycodone.
  • If you miss a dose of oxycodone and you are taking it regularly, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use oxycodone.

Important safety information:

  • Oxycodone may cause dizziness, drowsiness, or light-headedness. These effects may be worse if you take it with alcohol or certain medicines. Take oxycodone with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not change your dose of oxycodone without checking with your doctor.
  • Do not drink alcohol or take any medicines that contain alcohol while you are taking oxycodone. If you are unsure if any of your medicines contain alcohol, contact your pharmacist.
  • Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are taking oxycodone; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Oxycodone may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Oxycodone may cause constipation. Talk with your doctor or pharmacist about using a stool softener or laxative to prevent or treat constipation. It is also important to maintain a diet adequate in fiber, drink plenty of water, and exercise to prevent constipation. If you become constipated while taking oxycodone, talk with your doctor or pharmacist.
  • Tell your doctor or dentist that you take oxycodone before you receive any medical or dental care, emergency care, or surgery.
  • Use oxycodone with caution in the ELDERLY; they may be more sensitive to its effects, especially breathing problems.
  • Oxycodone should be used with extreme caution in CHILDREN younger than 18 years of age; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY AND BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking oxycodone while you are pregnant. Oxycodone is found in breast milk. Do not breast-feed while taking oxycodone.

When used for long periods of time or at high doses, oxycodone may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if oxycodone stops working well. Do not take more than prescribed.

Some people who use oxycodone for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction.

If you suddenly stop taking oxycodone, you may experience WITHDRAWAL symptoms, including anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; and trouble sleeping.

Possible side effects of oxycodone:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; headache; nausea; sleeplessness; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion; difficult or painful urination; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; seizures; severe or persistent dizziness or light-headedness; slowed or difficult breathing; sudden, severe headache or vomiting; swelling of the hands, ankles, or feet; tremor; unusual tiredness or weakness; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include bluish skin or nails; or cold and clammy skin; confusion; decreased pupil size; loss of consciousness; severe drowsiness, dizziness, or light-headedness; severe muscle weakness; slow or difficult breathing; slow heartbeat.

Proper storage of oxycodone:

Store oxycodone at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from light, heat, and moisture. Do not store in the bathroom. Keep oxycodone out of the reach of children and away from pets.

General information:

  • If you have any questions about oxycodone, please talk with your doctor, pharmacist, or other health care provider.
  • Oxycodone is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take oxycodone or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about oxycodone. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to oxycodone. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using oxycodone.

Issue Date: December 3, 2014
Database Edition 14.4.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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