Generic Name: acetaminophen and oxycodone (a SEET a MIN oh fen and OX i KOE done)
Brand Names: Endocet, Percocet, Primlev, Roxicet, Xartemis XR
What is Percocet?
Percocet contains a combination of acetaminophen and oxycodone. Oxycodone is an opioid pain medication. An opioid is sometimes called a narcotic. Acetaminophen is a less potent pain reliever that increases the effects of oxycodone.
Percocet is used to relieve moderate to severe pain.
Percocet may also be used for purposes not listed in this medication guide.
You should not use Percocet if you have recently used alcohol, sedatives, tranquilizers, or other narcotic medications.
Oxycodone can slow or stop your breathing. Never use Percocet in larger amounts, or for longer than prescribed. Narcotic pain medicine may be habit-forming, even at regular doses. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. MISUSE OF NARCOTIC MEDICATION CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.
Tell your doctor if you are pregnant. Oxycodone may cause life-threatening withdrawal symptoms in a newborn.
Do not use Percocet if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.
Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Call your doctor at once if you have nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of your skin or eyes).
In rare cases, acetaminophen may cause a severe skin reaction. Stop taking Percocet and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.
Before taking this medicine
You should not use Percocet if you are allergic to acetaminophen (Tylenol) or oxycodone, or if:
you have severe asthma or breathing problems;
you have a bowel obstruction called plytic ileus; or
you have recently used alcohol, sedatives, tranquilizers, or other narcotic medications.
Do not use Percocet if you have taken a MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.
Some medicines can interact with oxycodone and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.
To make sure Percocet is safe for you, tell your doctor if you have:
any type of breathing problem or lung disease;
liver disease, cirrhosis, or if you drink more than 3 alcoholic beverages per day;
a history of drug abuse, alcohol addiction, or mental illness;
diarrhea, inflammatory bowel disease, or a blockage in your stomach or intestines;
kidney disease, urination problems;
problems with your gallbladder, pancreas, or thyroid; or
a history of head injury, brain tumor, or seizures.
This medicine is more likely to cause breathing problems in older adults and people who are severely ill, malnourished, or otherwise debilitated.
Oxycodone may be habit forming. Never share Percocet with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away Percocet to any other person is against the law.
If you use oxycodone while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant.
Acetaminophen and oxycodone may pass into breast milk and could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
How should I take Percocet?
Take Percocet exactly as prescribed. Follow all directions on your prescription label. Never take Percocet in larger amounts, or for longer than prescribed. An overdose can damage your liver or cause death. Tell your doctor if the medicine seems to stop working as well in relieving your pain.
Drink 6 to 8 full glasses of water daily to help prevent constipation while you are taking Percocet. Do not use a stool softener (laxative) without first asking your doctor.
Percocet can cause unusual results with certain urine tests. Tell any doctor who treats you that you are using Percocet.
If you need surgery, tell the surgeon ahead of time that you are using acetaminophen and oxycodone. You may need to stop using the medicine for a short time.
Do not stop using Percocet suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using this medicine.
Store Percocet at room temperature away from moisture and heat.
Keep track of the amount of medicine used from each new bottle. Oxycodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.
Always check your bottle to make sure you have received the correct pills (same brand and type) of medicine prescribed by your doctor. Ask the pharmacist if you have any questions about the medicine you receive at the pharmacy.
Do not keep leftover Percocet tablets. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush any unused tablets down the toilet. Disposal of medicines by flushing is recommended to reduce the danger of accidental overdose causing death. This advice applies to a very small number of medicines only. The FDA, working with the manufacturer, has determined this method to be the most appropriate route of disposal and presents the least risk to human safety.
See also: Dosage Information (in more detail)
What happens if I miss a dose?
Since Percocet is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Percocet can be fatal.
The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.
Overdose symptoms may also include extreme drowsiness, pinpoint pupils, cold and clammy skin, muscle weakness, fainting, weak pulse, slow heart rate, coma, blue lips, shallow breathing, or no breathing
What should I avoid?
This medication may impair your thinking or reactions. Avoid driving or operating machinery until you know how Percocet will affect you. Dizziness or severe drowsiness can cause falls or other accidents.
Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.
Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen.
Percocet side effects
Get emergency medical help if you have any signs of an allergic reaction to Percocet: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking Percocet and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen.
Call your doctor at once if you have:
shallow breathing, slow heartbeat;
a light-headed feeling, like you might pass out;
confusion, unusual thoughts or behavior;
problems with urination;
infertility, missed menstrual periods;
impotence, sexual problems, loss of interest in sex;
liver problems - nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
low cortisol levels - nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Common Percocet side effects include:
upset stomach, constipation;
blurred vision; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Percocet?
Some medicines can cause unwanted or dangerous effects when used with oxycodone. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using.
Taking this medicine with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before taking Percocet with a sleeping pill, muscle relaxer, other pain medicine, or medicine for anxiety, depression, or seizures.
Other drugs may interact with acetaminophen and oxycodone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
More about Percocet (acetaminophen / oxycodone)
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about Percocet.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Percocet only for the indication prescribed.
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Copyright 1996-2016 Cerner Multum, Inc. Version: 15.10. Revision Date: 2016-03-28, 9:44:46 AM.