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User Reviews for Duloxetine

Also known as: Cymbalta, Irenka

The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.

Learn more about Duloxetine.

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Condition DownUp Reviews Compare Avg. Ratings DownUp
Dysthymia 1 reviews 3 medications
   
10
Generalized Anxiety Disorder 62 reviews 7 medications
   
7.4
Pain 62 reviews 1070 medications
   
7.4
Anxiety 141 reviews 63 medications
   
7.2
Osteoarthritis 19 reviews 348 medications
   
6.9
Peripheral Neuropathy 18 reviews 6 medications
   
6.8
Depression 373 reviews 78 medications
   
6.8
Bipolar Disorder 29 reviews 33 medications
   
6.8
Fibromyalgia 169 reviews 20 medications
   
6.7
Diabetic Peripheral Neuropathy 26 reviews 40 medications
   
6.5
Major Depressive Disorder 31 reviews 46 medications
   
6.4
Back Pain 23 reviews 178 medications
   
6.4
Hot Flashes 6 reviews 19 medications
   
6.2
Chronic Pain 64 reviews 111 medications
   
5.9
Chronic Fatigue Syndrome 5 reviews 2 medications
   
5.7
Urinary Incontinence 4 reviews 49 medications
   
4.4
Summary of Duloxetine reviews 1033 reviews 6.7

Reviews for Duloxetine

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Cymbalta (duloxetine) for Generalized Anxiety Disorder: "I have severe anxiety depression. I've tried all the meds out, as my doctor would say. Cymblatla was suggested. And me needing to feel normal tried it. Worst experience of my life. Was on 40mg. Felt like I was having an out of body experience, like someone was pulling me, everywhere. Dr told to stick with it, and lower dose (I actually did, did not recommend talk to Dr first). Nothing changed. I was talking without thinking, having more and more panic attacks and higher anxiety. Absolutely zero libido, and I gained weight. I felt "happy", but a weird happy. So, finally I TELL my doctor for the third time in 9 months, I want off this medication. Withdrawl symptoms no joke. It's been a month and I still have w.d effects"

   
2.0

#areallthegoodnamestaken May 2, 2016

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Cymbalta (duloxetine) for Depression: "I'm going to jump right into the fact that this medication is just not helpful, it takes away my personality, and has brought a lot of suicidal thoughts to mind. I am on 60 my capsule and the way it makes me feel is very empty. I don't feel like I have control of my thoughts and happiness"

   
1.0

Angela Christine May 2, 2016

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Cymbalta (duloxetine) for Depression: "Cymbalta saved my life 2 times. I've been taking those pills (60 mg) for both cases of depression. Everytime this drug worked like a miracle on me. It made me come back to normal. I have felt almost none side effects. First week, just diahrrea, some ticklings and a bit of tinitus. Nothing annoying at all. Then, everything went to normal again. I'm here in part thanks to Cymbalta."

   
9.0

Durauguiru (taken for 1 to 2 years) May 2, 2016

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For Generalized Anxiety Disorder: "23yo M - This medication is a god send for me in complete honesty. I have had problems with GAD for around 4 years. Previously I've tried Citalopram which was effective for treating my issues, but had side effects in my sexual life which was not possible to overcome. I tried Venlafaxine which was similarly effective but also had the same side effects - took too long rather than nothing at all! I gave up on the current generation of anti-depressant medication before trying Duloxetine. This is in the same category as Venlafaxine although not as strong. I've gone straight from VF into Duloxetine and after 20 days have found this medication to be extremely effective. More than any other SSRI or SNRI. For once I feel like a normal person!"

   
9.0

inf-czR April 30, 2016

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Cymbalta (duloxetine) for Depression: "I was prescribed Cymbalta for postpartum depression.What I really needed was sleep.I was after having a c-section and taking care of three kids and no help.Now I have been on this drug for 9 years. I have tried several times to get off it. I feel like it has a choke hold around my neck. I am a registered nurse and work full time. I still get depressed while on this drug. When I try to get off it I have suicidal thoughts along with a long list of withdrawal symptoms. I wish I was never put on this nasty drug."

   
1.0

boardwalk70 April 30, 2016

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Cymbalta (duloxetine) for Major Depressive Disorder: "I started cymbalta at 24 and I'm now 32... I changed to them after I had my first born but from 18 years old I was on Luvox! Yes first year or so I felt the cymbalta helped me a lot. More then the Luvox ever did. But for about a while now I really have noticed the bad things.... I get a migraine if i haven't taken one by 6pm. I get snappy and angry if I just miss one day... Last yr i Kept forgetting to take my scripted into get filled. After a few days I was yelling and crying and dug myself in a hole! I couldn't get out of bed the war in my head was so bad! My fam even called doctors on me because they were that worried.... The doctors advice was to go back on my cymbalta and start councelling! I want to change it but I hate it!"

   
2.0

LizaMac84 April 30, 2016

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Cymbalta (duloxetine) for Osteoarthritis: "Had severe arthritis, knees, hips,wrists, back below shoulder blades also middle in front left pectorial muscle, while in hospital dr gave me cymbalta, after 3 days pain level went from 7 down to about 2 1/2. All pain gone from knees which were in constant pain no side effects that I have notice so far"

THOMAS O (taken for less than 1 month) April 29, 2016

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Cymbalta (duloxetine) for Back Pain: "I would not have taken this medication if I knew it was going to effect my sex drive. I am thankful that I was only on it for a short time and I have stopped taking it a few days ago. I have been married for a longtime but we have a very active sex life now that our children are gone from the house. If I would have known that I wouldn't be able to have a orgasm during sex I never would have agreed to taking this drug. So if you value your intimacy with your partner do not take this drug or expect a lot of frustration !!!"

   
1.0

Mrsofty April 26, 2016

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Cymbalta (duloxetine) for Generalized Anxiety Disorder: "These pharmaceutical companies need to figure out ways to engineer better medications. I went on cymbalta for about 8 months after a long struggle with anxiety. I had mild depressive episodes as well, but it didn't really bother me and mostly came as a result of having bad anxiety that I felt I couldn't control. Cymbalta was great at first, I seemed to actually lose a little weight (didn't need to but any girl likes to see that) and I had a great mood much of the time. However, I started noticing that it wasn't doing anything for my actual anxiety. It started making me gain weight, I was too tired from the medicine to go the gym, and had a hard time even making it to the library to study (I'm a college student)."

   
5.0

Sophia1234567 April 25, 2016

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Cymbalta (duloxetine) for Depression: "I have suffered from severe depression for over 20 years. Cymbalta the only one thing that has kept me going and feeling normal. I still have a little depression but by far I am way better less breakdown and crying and sadness. Just make sure you have your doctor check your liver. I have not had any liver issues but some people have reported it. Give it a try it is work for me and I know some people out there saying it's the worst but for me it has been a lifesaver"

   
9.0

Colorado Native (taken for 2 to 5 years) April 24, 2016

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Cymbalta (duloxetine) for Depression: "I would give cymbalta a 10/10 however I have not been on it long enough to give it a perfect score. I have tried Prozac as well as wellbutrin to help cope with my crippling depression but they just didn't do the job. Before cymbalta I was easily aggitated, hating the world around me, and contemplating suicide. Now it is like a weight has been lifted off of my shoulders. I'm not irritated by small things anymore. I have more motivation. The only downside is have had is some insomnia but it should pass. Don't be scared by all the negative reviews. I was until I took it for myself. Everyone is different however you will have to try it for yourself to know. I take 30 milligrams once a day in the morning."

   
9.0

Dmhoward April 23, 2016

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For Depression: "• 19 Apr. 2016 Began initial dose at 2230 hours. Felt the medicine working within a ½ hour. Was in a good mood as I had been taken off of Warfarin this date. Before drifting off to sleep, I glanced at the clock. It was approx. 2300 hrs. I had an odd feeling in my throat that was possibly closing up. I remember worrying what is going on here? As the feeling in my throat persisted, I also felt my “Adam’s apple” fluttering and an elevated heart rate. I soon fell asleep. No other meds taken except for Atorvastatin. • 20 Apr. 2016 I awoke a 0600 hours to go to the bathroom. Upon arising, I felt a damp spot at the back of my underwear. Pulled the sheets back a discovered I had Shit the bed in my sleep. Felt real dizzy and drowsy. Thought to myself “how & why?” this happened. Went to shower. As the morning continued on at 0630, the side effects were evident: 1. “Hot flashes” Absolutely miserable. Could not get / stay comfortable. Firstly, had the flushing sweats, then I would get too cold. Turning off the air conditioner and fan for about a half an hour, Becoming hot again. This has continued on and has not stopped. Extremely bad migraines as well since waking and did not let up at all. Sensitive to noise, light and sounds. 2. The same feeling in my throat upon waking, I drank water to cool off and see if this would stop. And it didn’t. 3. My face was tingling all over as well. 4. Moderately nauseous upon standing up or sitting down. The nausea had continued all day. Had a special K cereal bar to ease this up in the morning. Having only relief from it less than an hour. 5. Tried eat cereal for lunch and discovered unable to eat it at all. The taste of it was making me sicker. 6. Took two 500 mg acetaminophen at 0700, relief was only slight and the head aches returned less than two hours. 7. Overall neck pain eased up and other arthritic symptoms did as well. I could definitley tell a difference, However the head ache did not. 8. Decided to take a dosage during the morning at 1000 hrs. To avoid loss of bowel control in my sleep. Within about two hours, felt it working through my system. Same effects I mentioned as before. Severe headaches and Nausea all day. And of course unbearable hot & cold feelings again thinking that these should eventually pass as I become used to it. 9. Laid down from 1400 to 1700 to alleviate the symptoms. Awoke from the nap and tried to eat dinner. One bite made me sick to my stomach. Headaches still there. 10. Overall, felt the same until bedtime as I did all day. Will give it one more try tomorrow morning. Did not take any meds except Atorvastatin, and two acetaminophen. • 21 April 2016 Awoke at 0815. No bowel leakage. Took another dose of Duloxetine at 1000. Was able to tolerate a cereal bar. Noticed the side effects once again and unable to have a bowel movement, within an hour of trying. I will now stop this medication. As I do not feel well at all and its side effects are terrible."

   
1.0

Chuck N_3 (taken for less than 1 month) April 22, 2016

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For Anxiety: "Severe hives. Cannot stop itching and a rash appears. Can be any part of my body and head. Drives me mad. But pros outweigh the cons as my anxiety has reduced so much."

   
8.0

JanJef April 20, 2016

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Cymbalta (duloxetine) for Depression: "The worst decision I have ever made was agreeing to go on this drug. I had no idea about SSRI's and the effects they can have on you and your life. For the first year, I would have recommended it to anyone dealing with depression and anxiety like myself..but that was at a time when I mistaked the numbness for satisfaction. Just over 2 years down the line and I am falling apart. This drug has ruined my life. First I realised the fog I was in. Then came the vertigo and confusion. My memory has deteriorated. Zero sex drive since day one. My depression has worsened and I no longer recognise who I am anymore. My personality has changed drastically and my anxiety is worse than its ever been. I am now weaning off it but the damage has been done."

   
1.0

DoNOTputYourselfThroughThisHel (taken for 2 to 5 years) April 19, 2016

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For Hot Flashes: "Complete hysterectomy 2003. Went through menopause w minimal hot flashes. Fast forward 2014-2016 started low dose cymbaltA for back pain after back surgery. CymbaltA seemed to help some w the pain. Dose increased to 40mg and eventually to 60mg. Hot flashes have been horrible. They come on fast and there is nothing that makes them better except sitting w a fan blowing on me. I have heard bad stories about stopping cymbalta and the side effects of that. I am fearful to stop but too hot to continue."

   
3.0

Hot momma (taken for 2 to 5 years) April 18, 2016

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Cymbalta (duloxetine) for Generalized Anxiety Disorder: "Was prescribed for depression, but it affected my panic disorder very much. I went from 6-7 panic attacks a day to 1-2 a week/month. It really really helped with my anxiety overall too. I feel less anxious. The initial 2 weeks were horrible though, increased anxiety, hot flashes. And it interacts with a lot of medications (including vitamin d supplements)"

   
6.0

Nfngkfng (taken for 1 to 2 years) April 11, 2016

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Cymbalta (duloxetine) for Anxiety: "Was prescribed for depression, but it affected my panic disorder very much. I went from 6-7 panic attacks a day to 1-2 a week/month. It really really helped with my anxiety. The initial 2 weeks were horrible though, increased anxiety, hot flashes. And it interacts with a lot of medications (including vitamin d supplements)"

   
8.0

Elliotndbfjf April 11, 2016

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Cymbalta (duloxetine) for Major Depressive Disorder: "I have had depression as far back as I can remember, diagnosed with GA and major depression along with PTSD due to two life changing events I went though. I've tried zoloft (did nothing ) Effexor XR ( Made me sleep 24/7) Celexa ( caused SEVERE anxiety attacks) and just started Cymbolta, on day 7 and I can't believe how much better I already feel at 30mg 1x day. I also just had 2 major back surgeries and am learning to walk again at age 35, yet despite my trials, I feel happier, positive, lowered anxiety etc. First day I did have severe throwing up spells, but that's gone, low appetite still but a good thing for me, INCREASED sex drive & sleep like a baby. I take it at 8 everyday. Good luck, everyone's different!"

   
10

Abelslove80 (taken for less than 1 month) April 8, 2016

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Cymbalta (duloxetine) for Generalized Anxiety Disorder: "I have been dealing with depression since 1990 and run the whole inventory of SSRI's available. Prozac was effective the first 2 years then became ineffective. The only drug that has helped me for an extended period of time was Paxil. Paxil eventually became ineffective after 5 years. So the wonder drug Cymbalta comes on the scene and I thought I had finally found the magical cure. I've been on 60 mg of Cymbalta for about a year and once again the roof is caving in and very abruptly. This past week I've been suicidal for 3 days. Why? The circumstances in my life that so often can trigger anxiety or depression are the same as always. How can an SSRI become instantaneously ineffective? I'm not raving about Cymbalta any longer."

   
5.0

Sparky1945 April 2, 2016

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Cymbalta (duloxetine) for Anxiety: "Changed my life. I had been experiencing slight bouts of anxiety starting at around age 19. Hitting me hard, randomly of course, only a few times a year. Then when I was 24 something changed with my anxiety and I became completely crippled by it. I was being consumed by constant anxiety, worry, fear, etc every single minute of everyday including when I slept. I was out of control emotionally and mentally. I had to take a box of tissues with me everywhere because the anxiety was so severe I would burst out into tears even during the "happiest" of times. Finally after suffering for months I decided to give Cymbalta a try, reluctantly though. After a week of relatively mild side effects it had changed my life and saved my life."

   
10

XYY DD (taken for 6 months to 1 year) April 2, 2016

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For Depression: "I got put on Klonopin 2mg 2x daily and Cymbalta 30mg 1x daily for Anxiety, Depression, Nerve pain, Muscle cramps, and chronic lower back pain. At first the Klonopin helped tremendously with all those symptoms. After 4 to 6 weeks of using Cymbalta, it finally released its magic. By far the best anti depressant I've tried. Compared to Zoloft, Wellbutrin, and Lexapro.. Cymbalta by far worked the best. I finally am stable, anxiety, pain, and depression free. Klonopin and Cymbalta is one hell of a great cocktail. But I must admit Cymbalta is a VERY expensive med, they run from 6 to 12 $ a pill at most pharmacies."

   
10

Klonopin2mgCymbalta30mg (taken for 6 months to 1 year) March 31, 2016

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Cymbalta (duloxetine) for Depression: "On the 10 day of 30 mg. I woke to a miracle . No chronic pain in my whole entire body for the first time in years. For years I suffered hour after hour with 4 and 5 in my back. Body pain so bad I was on Norco for years. Nothing has been more effective to my pain and depression as this medicine. I hope more physicians prescribe this medicine for these reasons. I have my life back."

   
10

Liz4444 (taken for 1 to 6 months) March 29, 2016

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Cymbalta (duloxetine) for Depression: "For over 20 years I've used antidepressants and this by far is the best I've ever used however there are some downsides I'm constantly hungry all d time I've put on 2stone which is giving me another problem to deal with cause that doesn't make me feel good and excessive sweating I've reduced my dose with doctors supervision to try help these side affects and the tiredness is sooo bad but I've definitely had little or no anxiety"

   
8.0

Anonymous (taken for 1 to 2 years) March 29, 2016

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For Bipolar Disorder: "I am 48 and have been struggling to break my roller coaster ride that is a BI-polar . I self medicated with alcohol for a long time , I became disabled 100% and Sober In 2008. In the past when I was drinking ,I would never give any meds a chance and my diagnoses would change with Dr's . Christmas time 2015 , my cycles were steady ,I am a single Father of 4 kids and my kids did not deserve This .My mental Health provider had tried so many different drugs WARNING !!!!! Be Honest with yourself and Your Health care team ,They are so much more effective if they know ALL OF YOUR STORY . I felt like I was at the of my rope and I would never feel like me again . This Medicine worked me Me very very well . Keep fighting"

   
9.0

Anonymous (taken for 1 to 6 months) March 28, 2016

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Cymbalta (duloxetine) for Chronic Pain: "The relief of pain was almost immediate. I have fibromyalgia and osteoarthritis as well. The meds localize the pain to a tolerable condition. I take the pill first thing in the mornings and it leaves me light-headed and fatigued until late afternoon. I wonder if these symptoms go away after a few months? Will my body get used to it?"

   
7.0

Grandma Cec March 27, 2016

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