User Reviews for Duloxetine

Also known as: Cymbalta

The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.

Learn more about Duloxetine.

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Condition DownUp Reviews Compare Avg. Ratings DownUp
Dysthymia 1 reviews 3 medications
   
10
Generalized Anxiety Disorder 28 reviews 6 medications
   
7.9
Pain 62 reviews 911 medications
   
7.4
Anxiety 113 reviews 60 medications
   
7.2
Bipolar Disorder 25 reviews 48 medications
   
7.0
Major Depressive Disorder 6 reviews 44 medications
   
7.0
Depression 287 reviews 75 medications
   
6.9
Peripheral Neuropathy 15 reviews 6 medications
   
6.8
Fibromyalgia 132 reviews 72 medications
   
6.8
Back Pain 13 reviews 169 medications
   
6.6
Diabetic Peripheral Neuropathy 20 reviews 40 medications
   
6.6
Osteoarthritis 13 reviews 366 medications
   
6.5
Chronic Pain 30 reviews 102 medications
   
6.2
Hot Flashes 4 reviews 33 medications
   
6.1
Chronic Fatigue Syndrome 5 reviews 2 medications
   
5.7
Urinary Incontinence 2 reviews 50 medications
   
4.0
Small Fiber Neuropathy 0 reviews 0 medications Not rated - Be the first
Summary of Duloxetine reviews 756 reviews 6.9

Reviews for Duloxetine

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Review by Ef1988:

User Rating:  
   
8.0

Cymbalta (duloxetine) for Anxiety: I started taking Cymbalta earlier this year for my anxiety. I found it really helped, but I didn't want to stay on it for long. I had a few side effects while being on Cymbalta such as night sweats, trouble sleeping and electric pulses through my body. Whilst gradually lowering my doses of Cymbalta these side effects did get a little worse, however they have completely gone now. I started lowering my doses in June, and now by the end of August the night sweats have completely stopped, my sleeping is back to normal, and the electric pulses are very rare. When I think about getting worried or anxious now, I just remember that its not a big deal and that if I was on Cymbalta I wouldn't have even thought about it.

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August 27, 2014 1:55 AM

Review by Mystee719 (taken for less than 1 month):

User Rating:  
   
7.0

Cymbalta (duloxetine) for Back Pain: After having tried a few other combination depression, pain medicines, this one finally seemed to work, and I got far less tired, or other side affects I'd gotten from the others, so far, I feel this is the best one I've tried, it has also helped with my mood.

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August 25, 2014 9:42 AM

Review by SusanF. (taken for 2 to 5 years):

User Rating:  
   
9.0

Cymbalta (duloxetine) for Major Depressive Disorder: I use Cymbalta 60mg at night. I sleep better, eat better, and feel better. Doctor diagnosed me with major depression disorder and placed me on Cymbalta and counseling. My life is 90% better! I am so thankful! Oh, and I had my thyroid checked: low thyroid. I take Synthroid 50mcg in the morning.

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August 22, 2014 12:01 AM

Review by BethAnnie:

Cymbalta (duloxetine) for Fibromyalgia: I was diagnosed with Fibromyalgia in 2004. I started out taking Flexeril and Tramadol 37.5. It was helping but I still had bad days. My doctor told me I would have good & bad days. I also tried Lyrica and another medicine (can't remember name that started with a S). Came off of Lyrica and then the S. I was put on Cymbalta started with 60 mg a day then upped to 120mg. It does not help with the Fibromyalgia but it does wonders for my mood swings and hot flashes.

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August 17, 2014 9:51 PM

Review by Meg78:

User Rating:  
   
8.0

Cymbalta (duloxetine) for Anxiety: I'm 5 weeks into taking Duloxetine for depression and anxiety and have had an overall positive experience. My anxiety was greatly reduced after only 4 days on 40mg per day including stopping negative thoughts, no more panic attacks at night etc. The second week I was very tired and depressed without the anxiety, sleeping many hours each day. But by the third week both depression and anxiety were greatly reduced. However by the end of the month the anxiety had started to return slightly and my doctor has now increased the dose to 80mg per day. I had slight nausea, dry mouth and loss of appetite, and some indigestion during the first week or so and now again since I have upped the dose but I imagine these will disappear again soon.

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August 13, 2014 2:48 PM

Review by Stuck on cymbalta (taken for 2 to 5 years):

User Rating:  
   
9.0

For Pain: I'd been taking Cymbalta for about 2 years when I decided that I didn't want to pay $30/mo anymore, so I decided that I would wean myself off. I tried and I started getting the brain zaps, like lightening in my head. So I started back, slowly I just started missing a dose here and there until I was able to stop them without the side effects. I've been off for several months now and I've noticed that I've been in more pain and everything that was hurting me before has compounded. So needless to say I'm starting them back. Appears that I'm not going to be able to do without it.

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August 12, 2014 10:57 PM

Review by pjs001:

User Rating:  
   
3.0

Cymbalta (duloxetine) for Osteoarthritis: I was prescribed Cymbalta for arthritic pain in my knees. I took 30 mg/day for 3 days and was fatigued to the point of not wanting to do anything but lie down.In addition (to which I found out was a rare side effect) I was yawning all day and evening. After reading about the difficulties that some people had getting off this medicine. I stopped it after the 3 days. Unless I can be somewhat assured that the side effects are temporary I would rather live with the pain then take this medicine.

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August 6, 2014 4:43 PM

Review by king bean (taken for 1 to 6 months):

User Rating:  
   
4.0

Cymbalta (duloxetine) for Anxiety: Didn't work for me. Felt pretty barfy and crummy first several days. Seemed to make me agitated. Only on it for a week; withdrawal was unpleasant. Just my experience, however.

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August 4, 2014 2:33 PM

Review by KRW2011:

User Rating:  
   
8.0

Cymbalta (duloxetine) for Generalized Anxiety Disorder: I have been taking Cymbalta for two years now- it honestly changed my life. At the time I started taking it I was a college athlete and anxiety ruled my life. At first, I would take it during the morning hours and I would immediately want to go to bed. That was my problem, I needed to take it about an hour or two before bed. I am still experimenting the exact right time to take it (I sometimes wake up still feeling tired from it- but not sure if it's the medication or my routine now). I know certain medications work for some and not others, but I would recommend this medication. I had slight symptoms at first beside the tiredness- decreased appetite and no sexual desires or emotions. I still feel great! (30mg once daily)

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July 24, 2014 11:58 AM

Review by Monchie:

User Rating:  
   
9.0

Cymbalta (duloxetine) for Anxiety: I just started taking this medication last night and ALREADY feel so much better. I've tried Prozac, Celexa, Zoloft, Buspar, Abilify, and countless others to help with my anxiety and none of them worked. This medication is a miracle in my opinion. I can't believe how quickly it works too. I'm taking this along with Atarax to help anxiety and panic attacks. I like the Atarax too and have not needed to take clonazepam today. Very happy. Only problem was that I couldn't sleep last night. I was physically exhausted and couldn't open my eyes or move but my mind was active. Hopefully this will pass. I've also had an upset stomach today with diarrhea but it beats anxiety any day!

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July 16, 2014 1:57 PM

Review by mommagedden6 (taken for 1 to 6 months):

User Rating:  
   
9.0

Cymbalta (duloxetine) for Depression: I started taking Cymbalta about one month ago. Initially the dose was 30mg for 2 weeks and 60mg following. I cannot believe how well this has helped me. I suffered with depression and severe anxiety. I will continue this medication as I understand full benefit may not be reached for several months. Overall I am extremely satisfied with Cymbalta. My only side effects are constipation and decreased appetite which I have resolved with Miralax and eating small meals more often. I also realized the increased taste of salt during my meals which has seemed to decrease more each day.

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July 14, 2014 6:14 AM

Review by Belva Watkins:

User Rating:  
   
10

Cymbalta (duloxetine) for Chronic Pain: The first pill very strong so waited till in bed and when the severe pain from shingles hit I took 2nd pill..instant relief. I was so glad I had the medicine and still have the bottle of pills as I never needed another. One pill got me through the worst pain I had with shingles. I would not have a need for any now but saved in case shingles returned. I think it a tad bit too strong for most pain that could be treated with a lessor degree of strength. 2 pills used out of whole bottle. It was expensive but actually just one pill did the job.

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July 13, 2014 8:44 PM

Review by Momma 1234:

User Rating:  
   
10

Cymbalta (duloxetine) for Diabetic Peripheral Neuropathy: Can't live without it

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July 7, 2014 6:48 PM

Review by danimom80 (taken for 1 to 6 months):

User Rating:  
   
9.0

Cymbalta (duloxetine) for Anxiety: I was quick to anger, severe mood swings would yell at my kids for the slightest things. I was ready to punch anybody that would make me mad and( it didn't take much!) I started with Cymbalta 30mg and I noticed a slight difference I was increased to 60 mg and I felt the change right away. I'm so calm and I'm back to being a happy mom. I take it at night because it would get me sleepy during the day if I take in the morning some of the side effects I've experienced have been dry mouth, lack of appetite, hot flashes, tiredness! I love this medicine it has changed my life. The relationship with my children is much much better too. I no longer have crying spells and I'm a much nicer person. Try Cymbalta.

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July 2, 2014 3:18 AM

Review by ohioscanner:

User Rating:  
   
10

Cymbalta (duloxetine) for Major Depressive Disorder: I have been taking Cymbalta for several years now. It works great for me. If I don't take it I cry. I take 60mg/day. It helps with my fibromyalgia also. I had tried many other medicines like Lexapro and nothing else worked for me.

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June 26, 2014 6:25 AM

Review by JosephRu (taken for 1 to 6 months):

User Rating:  
   
1.0

For Diabetic Peripheral Neuropathy: Causes erectile dysfunction, and raises blood sugar x 2 times..

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June 18, 2014 11:45 AM

Review by Issieanne (taken for less than 1 month):

Cymbalta (duloxetine) for Chronic Pain: After Just having begun my regimen on Duloxetine (2 days now) I am very encouraged with the relief I am experiencing. I have fought the pain from Rheumatoid Arthritis since Age 6...I am now 69 In the interim I've since had aggressive Fibromyalgia / AND Aggressive debilitating BRAIN FOG WITH Memory Loss (Prior to this I've been thinking seriously about checking my brain for Alzheimers). Now I am encouraged with results so far......HAPPY DAY! May this keep on working in my case this time. Many many Thanks.

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June 17, 2014 7:14 PM

Review by ISSIANN:

Cymbalta (duloxetine) for Fibromyalgia: After being on others this, seems to be a God send. Just finishing up DAY 2. Yesterday was tough as I still have residual amounts of citalopram in my system I suppose. Wish me good luck!

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June 17, 2014 6:39 PM

Review by annalee66 (taken for less than 1 month):

User Rating:  
   
9.0

Cymbalta (duloxetine) for Depression: I'm suffering from Depression, Borderline Personality Disorder, OCD and PSTD. With the exception of feeling a little sick after taking it, Cymbalta had helped me after only a few days. I've tried Effexor, Zoloft, Paxil, Pristique, Prozac, Ciraplex, Seroquel, Trazodone, Amitriptyline and a few more I cant remember the names. I think everyone responds different to medications and all you can do is keep trying and not give up. My mental illness has had a negative impact on my life and ruined many personal relationships too. I have never had any medication work this fast or so well before.

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June 16, 2014 12:25 AM

Review by DisneyFreak:

User Rating:  
   
9.0

Cymbalta (duloxetine) for Fibromyalgia: I had tried Lyrica for fibromyalgia & it made me severely tired, and didn't help the aches & pains at all. Once I switched to Cymbalta, I felt great! The aches & pains were reduced by at least 75% within 2 weeks! I've been on it 1.5 years & have had a gradual weight gain totaling 20lbs that started the same month I started the Cymbalta. My rheumatologist says its not Cymbalta related, but I'm thinking of maybe trying another medicine just to see. But I'm afraid nothing will work as well as the Cymbalta. I also take 250mg Soma at night to help me sleep which works great.

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June 11, 2014 8:01 AM

Review by tiggergal (taken for less than 1 month):

User Rating:  
   
8.0

Cymbalta (duloxetine) for Anxiety: After trying two other medicines with horrible side effects and no results, Cymbalta finally did the trick! The side effects were mild (hot flashes, some shakiness, etc) have mostly subsided and I'm sleeping better.

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June 9, 2014 3:52 PM

Review by Fitzy2211:

User Rating:  
   
9.0

Cymbalta (duloxetine) for Major Depressive Disorder: I was on 100mg of Pristiq which really wasn't working for me. I stopped taking medication and started having suicidal thoughts. A friend recommended Cymbalta so I saw a Dr and started on 30mg. Within a month my depression was nearly non-existent. I had off days but overall it was amazing. After the month though, I noticed I was starting to feel down and irritable towards the end of the day (I take mine at night before sleep) I've been increased to 60 mg and I can't be happier. I have not felt this calm and happy with life in close on 7 years There are noticeable side effects for me. I have extremely vivid dreams most nights and I can recall most of them upon waking. Also loss of appetite is a big one.

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June 6, 2014 12:43 AM

Review by neuro12 (taken for 10 years or more):

User Rating:  
   
10

For Dysthymia: I have been diagnosed with dysthymia since 2004. Little was known about or how to treat at that time. Now we know so much and how to treat. It even has a new name. Cymbalta gave me a chance at life again in so many ways. Dysthymia has no chance against Cymbalta! Cymbalta is amazing!

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May 23, 2014 8:44 PM

Review by Merytle:

User Rating:  
   
8.0

Cymbalta (duloxetine) for Chronic Pain: Cymbalta has given me such great relief from pain for many years. Unfortunately I fall in the 1% of severe side effects. I've had no need for narcotics except for acute pain for migraines or injuries during this time. Unfortunately I have put on so much weight and my liver is enlarged and enzymes are high due to taking this medicine. Even with years of intense exercising 3-5 days a week I was unable to lose any significant weight. I must now stop taking it and I don't know of anything else that will give me this relief. Still highly recommend this for others who are most likely not going to have this trouble. But be aware just in case you fall in the 1% also. Especially if taking other medicines.

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May 22, 2014 10:50 AM

Review by Anonymous (taken for 2 to 5 years):

User Rating:  
   
7.0

Cymbalta (duloxetine) for Chronic Pain: I have been taking Cymbalta for about 2 years. I can tell a major difference with an over all improvement and/or tolerance level of pain; I can ,as well, tell that it seems to improve the efficacy of two other medications I am given (morphine and tramadol) Or prescribed, as compared to when I (have done one or two trial periods purposefully x1 and accidentally) missed 4-7 days of not taking the Cymbalta.

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May 19, 2014 7:01 AM

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